个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共42条记录   Heterosubtypic neutralizing antibodies are produced by individuals immunized with a seasonal influenza vaccine [作者：Corti, D; Suguitan, AL; Pinna, D; Silacci, C; Fernandez-Rodriguez, BM; Vanzetta, F; Santos, C; Luke, CJ; Torres-Velez, FJ; Temperton, NJ; Weiss, RA; Sallusto, F; Subbarao, K; Lanzavecchia, A,期刊：Journal of clinical investigation, 页码：1663-1673 , 文章类型： Article，,卷期：2010年120-5] The target of neutralizing antibodies that protect against influenza virus infection is the viral protein HA. Genetic and antigenic variation in HA has been used to classify influenza viruses into subtypes (H1-H16). The ... Intranasal Poly-IC treatment exacerbates tuberculosis in mice through the pulmonary recruitment of a pathogen-permissive monocyte/macrophage population [作者：Antonelli, LRV; Rothfuchs, AG; Goncalves, R; Roffe, E; Cheever, AW; Bafica, A; Salazar, AM; Feng, CG; Sher, A,期刊：Journal of clinical investigation, 页码：1674-1682 , 文章类型： Article，,卷期：2010年120-5] Type I IFN has been demonstrated to have major regulatory effects on the outcome of bacterial infections. To assess the effects of exogenously induced type I IFN on the outcome of Mycobacterium tuberculosis infection, we... Real-time imaging of trapping and urease-dependent transmigration of Cryptococcus neoformans in mouse brain [作者：Shi, MQ; Li, SS; Zheng, CF; Jones, GJ; Kim, KS; Zhou, H; Kubes, P; Mody, CH,期刊：Journal of clinical investigation, 页码：1683-1693 , 文章类型： Article，,卷期：2010年120-5] Infectious meningitis and encephalitis is caused by invasion of circulating pathogens into the brain. It is unknown how the circulating pathogens dynamically interact with brain endothelium under shear stress, leading to... Direct transcriptional regulation of neuropilin-2 by COUP-TFII modulates multiple steps in murine lymphatic vessel development [作者：Lin, FJ; Chen, XP; Qin, J; Hong, YK; Tsai, MJ; Tsai, SY,期刊：Journal of clinical investigation, 页码：1694-1707 , 文章类型： Article，,卷期：2010年120-5] The lymphatic system plays a key role in tissue fluid homeostasis. Lymphatic dysfunction contributes to the pathogenesis of many human diseases, including lymphedema and tumor metastasis. However, the mechanisms regulati... Loss of enteroendocrine cells in mice alters lipid absorption and glucose homeostasis and impairs postnatal survival [作者：Mellitzer, G; Beucher, A; Lobstein, V; Michel, P; Robine, S; Kedinger, M; Gradwohl, G,期刊：Journal of clinical investigation, 页码：1708-1721 , 文章类型： Article，,卷期：2010年120-5] At least 10 enteroendocrine cell types have been identified, and the peptide hormones they secrete have diverse functions that include regulation of glucose homeostasis, food intake, and gastric emptying. Mice lacking in... Don't ask, don't tell ... and don't donate [作者：Neill, US,期刊：Journal of clinical investigation, 页码：1364-1364 , 文章类型： Editorial Material，,卷期：2010年120-5] Did you know that gay men can't donate blood, nor can they donate sperm anonymously to sperm banks? I applaud the 18 senators who have banded together to urge FDA Commissioner Margaret Hamburg to revisit this issue, as c... Jeff Bluestone steps from bench to bedside to chief academic officer [作者：Neill, US,期刊：Journal of clinical investigation, 页码：1365-1365 , 文章类型： News Item，,卷期：2010年120-5] Trafficking of immune cells in the central nervous system [作者：Wilson, EH; Weninger, W; Hunter, CA,期刊：Journal of clinical investigation, 页码：1368-1379 , 文章类型： Article，,卷期：2010年120-5] The CNS is an immune-privileged environment, yet the local control of multiple pathogens is dependent on the ability of immune cells to access and operate within this site. However, inflammation of the distinct anatomica... Some new insights into the molecular mechanisms of pain perception [作者：Brown, DA; Passmore, GM,期刊：Journal of clinical investigation, 页码：1380-1383 , 文章类型： Editorial Material，,卷期：2010年120-5] Bradykinin is the most potent endogenous inducer of acute pain. However, the way in which it excites nociceptive sensory nerve endings is still unclear. In an article recently published in the JCI, Liu et al. suggest a n... Neuronal injury: folate to the rescue? [作者：Kronenberg, G; Endres, M,期刊：Journal of clinical investigation, 页码：1383-1386 , 文章类型： Editorial Material，,卷期：2010年120-5] Strong epidemiological evidence indicates that derangement of single-carbon metabolism has detrimental effects for proper CNS functioning. Conversely, a role for folate supplementation in the treatment and prevention of ... p63 and IRF6: brothers in arms against cleft palate [作者：Gritli-Linde, A,期刊：Journal of clinical investigation, 页码：1386-1389 , 文章类型： Editorial Material，,卷期：2010年120-5] Cleft lip and cleft palate, which can also occur together as cleft lip and palate, are frequent and debilitating congenital malformations, with complex geneses that have both genetic and environmental factors implicated.... Cryptococci at the brain gate: break and enter or use a Trojan horse? [作者：Casadevall, A,期刊：Journal of clinical investigation, 页码：1389-1392 , 文章类型： Editorial Material，,卷期：2010年120-5] The mechanism by which Cryptococcus neoformans invades the central nervous system is fundamental for understanding pathogenesis because cryptococcosis commonly presents as meningoencephalitis. There is evidence for both ... Caveat mTOR: aberrant signaling disrupts corticogenesis [作者：Osborne, LR,期刊：Journal of clinical investigation, 页码：1392-1395 , 文章类型： Editorial Material，,卷期：2010年120-5] The mammalian target of rapamycin (mTOR) signaling pathway is activated in several disorders associated with benign tumors and malformations of the cerebral cortex. In this issue of the JCI, Orlova et al. have now defini... Reevaluation of the role of HDL in the anticoagulant activated protein C system in humans [作者：Oslakovic, C; Norstrom, E; Dahlback, B,期刊：Journal of clinical investigation, 页码：1396-1399 , 文章类型： Article，,卷期：2010年120-5] HDL has anti-atherogenic properties, and plasma levels of HDL cholesterol correlate inversely with risk of coronary artery disease. HDL reportedly functions as a cofactor to the anticoagulant activated protein C (APC) in... Group III secreted phospholipase A(2) regulates epididymal sperm maturation and fertility in mice [作者：Sato, H; Taketomi, Y; Isogai, Y; Miki, Y; Yamamoto, K; Masuda, S; Hosono, T; Arata, S; Ishikawa, Y; Ishii, T; Kobayashi, T; Nakanishi, H; Ikeda, K; Taguchi, R; Hara, S; Kudo, I; Murakami, M,期刊：Journal of clinical investigation, 页码：1400-1414 , 文章类型： Article，,卷期：2010年120-5] Although lipid metabolism is thought to be important for the proper maturation and function of spermatozoa, the molecular mechanisms that underlie this dynamic process in the gonads remains incompletely understood. Here,... Group X phospholipase A(2) is released during sperm acrosome reaction and controls fertility outcome in mice [作者：Escoffier, J; Jemel, I; Tanemoto, A; Taketomi, Y; Payre, C; Coatrieux, C; Sato, H; Yamamoto, K; Masuda, S; Pernet-Gallay, K; Pierre, V; Hara, S; Murakami, M; De Waard, M; Lambeau, G; Arnoult, C,期刊：Journal of clinical investigation, 页码：1415-1428 , 文章类型： Article，,卷期：2010年120-5] Ejaculated mammalian sperm must undergo a maturation process called capacitation before they are able to fertilize an egg. Several studies have suggested a role for members of the secreted phospholipase Ay (sPLA(2)) fami...