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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共45条记录   Uric acid transport and disease [作者：So, A; Thorens, B,期刊：Journal of clinical investigation, 页码：1791-1799 , 文章类型： Article，,卷期：2010年120-6] Uric acid is the metabolic end product of purine metabolism in humans. It has antioxidant properties that may be protective but can also be pro-oxidant, depending on its chemical microenvironrnent. Hyperuricemia predispo... Early tumor dissemination, but late metastasis: insights into tumor dormancy [作者：Rocken, M,期刊：Journal of clinical investigation, 页码：1800-1803 , 文章类型： Editorial Material，,卷期：2010年120-6] The classical model of metastasis is that tumor cell dissemination occurs late in tumor development, after the primary tumor has grown, and that only then will tumor cells invade the local tissue, enter the blood or lymp... Gazing into a crystal ball to predict kidney transplant outcome [作者：Schroppel, B; Heeger, PS,期刊：Journal of clinical investigation, 页码：1803-1806 , 文章类型： Editorial Material，,卷期：2010年120-6] Kidney transplantation is the optimal therapy for end-stage kidney disease but requires lifelong immunosuppression. Despite improvements in immunosuppression regimens that have reduced rates of acute transplant rejection... Revisiting an old acquaintance: role for elF5A in diabetes [作者：Hauber, J,期刊：Journal of clinical investigation, 页码：1806-1808 , 文章类型： Editorial Material，,卷期：2010年120-6] Dysfunction of pancreatic islet beta cells underlies both type 1 and type 2 diabetes and appears to result in part from the local release of proinflammatory cytokines. An improved understanding of the mechanisms that med... The unique hypusine modification of eIF5A promotes islet beta cell inflammation and dysfunction in mice [作者：Maier, B; Ogihara, T; Trace, AP; Tersey, SA; Robbins, RD; Chakrabarti, SK; Nunemaker, CS; Stull, ND; Taylor, CA; Thompson, JE; Dondero, RS; Lewis, EC; Dinarello, CA; Nadler, JL; Mirmira, RG,期刊：Journal of clinical investigation, 页码：2156-2170 , 文章类型： Article，,卷期：2010年120-6] In both type 1 and type 2 diabetes, pancreatic islet dysfunction results in part from cytokine-mediated inflammation. The ubiquitous eukaryotic translation initiation factor 5A (eIF5A), which is the only protein to conta... Hypoxia-inducible factor-1 alpha regulates beta cell function in mouse and human islets [作者：Cheng, K; Ho, K; Stokes, R; Scott, C; Lau, SM; Hawthorne, WJ; O'Connell, PJ; Loudovaris, T; Kay, TW; Kulkarni, RN; Okada, T; Wang, XHL; Yim, SH; Shah, Y; Grey, ST; Biankin, AV; Kench, JG; Laybutt, DR; Gonzalez, FJ; Kahn, CR; Gunton, JE,期刊：Journal of clinical investigation, 页码：2171-2183 , 文章类型： Article，,卷期：2010年120-6] Hypoxia-inducible factor-1 alpha (HIF-1 alpha) is a transcription factor that regulates cellular stress responses. While the levels of HIF-1 alpha protein are tightly regulated, recent studies suggest that it can be acti... Caught red-handed: uric acid is an agent of inflammation [作者：Shi, Y,期刊：Journal of clinical investigation, 页码：1809-1811 , 文章类型： Editorial Material，,卷期：2010年120-6] Inflammation occurs in response to both pathogenic insult and tissue damage under sterile conditions, with the latter contributing to the pathogenesis of many diseases. Although several endogenous substances, including u... PDZD7 is a modifier of retinal disease and a contributor to digenic Usher syndrome [作者：Ebermann, I; Phillips, JB; Liebau, MC; Koenekoop, RK; Schermer, B; Lopez, I; Schafer, E; Roux, AF; Dafinger, C; Bernd, A; Zrenner, E; Claustres, M; Blanco, B; Nurnberg, G; Nurnberg, P; Ruland, R; Westerfield, M; Benzing, T; Bolz, HJ,期刊：Journal of clinical investigation, 页码：1812-1823 , 文章类型： Article，,卷期：2010年120-6] Usher syndrome is a genetically heterogeneous recessive disease characterized by hearing loss and retinitis pigmentosa (RP). It frequently presents with unexplained, often intrafamilial, variability of the visual phenoty... The G(q)/G(11)-mediated signaling pathway is critical for autocrine potentiation of insulin secretion in mice [作者：Sassmann, A; Gier, B; Grone, HJ; Drews, G; Offermanns, S; Wettschureck, N,期刊：Journal of clinical investigation, 页码：2184-2193 , 文章类型： Article，,卷期：2010年120-6] A variety of neurotransmitters, gastrointestinal hormones, and metabolic signals are known to potentiate insulin secretion through GPCRs. We show here that beta cell-specific inactivation of the genes encoding the G prot... Tissue-type plasminogen activator is a neuroprotectant in the mouse hippocampus [作者：Echeverry, R; Wu, JL; Haile, WB; Guzman, J; Yepes, M,期刊：Journal of clinical investigation, 页码：2194-2205 , 文章类型： Article，,卷期：2010年120-6] The best-known function of the serine protease tissue-type plasminogen activator (tPA) is as a thrombolytic enzyme. However, it is also found in structures of the brain that are highly vulnerable to hypoxia-induced cell ... Paracrine signaling by glial cell-derived triiodothyronine activates neuronal gene expression in the rodent brain and human cells [作者：Freitas, BCG; Gereben, B; Castillo, M; Kallo, I; Zeold, A; Egri, P; Liposits, Z; Zavacki, AM; Maciel, RMB; Jo, S; Singru, P; Sanchez, E; Lechan, RM; Bianco, AC,期刊：Journal of clinical investigation, 页码：2206-2217 , 文章类型： Article，,卷期：2010年120-6] Hypothyroidism in humans is characterized by severe neurological consequences that are often irreversible, highlighting the critical role of thyroid hormone (TH) in the brain. Despite this, not much is known about the si... p120-catenin is essential for maintenance of barrier function and intestinal homeostasis in mice [作者：Smalley-Freed, WG; Efimov, A; Burnett, PE; Short, SP; Davis, MA; Gumucio, DL; Washington, MK; Coffey, RJ; Reynolds, AB,期刊：Journal of clinical investigation, 页码：1824-1835 , 文章类型： Article，,卷期：2010年120-6] Epithelial-cadherin (E-cadherin) is a master organizer of the epithelial phenotype. Its function is regulated in part by p120-catenin (referred to herein as p120), a cytoplasmic binding partner that directly regulates ca... Identification of a B cell signature associated with renal transplant tolerance in humans [作者：Newell, KA; Asare, A; Kirk, AD; Gisler, TD; Bourcier, K; Suthanthiran, M; Burlingham, WJ; Marks, WH; Sanz, I; Lechler, RI; Hernandez-Fuentes, MP; Turka, LA; Seyfert-Margolis, VL,期刊：Journal of clinical investigation, 页码：1836-1847 , 文章类型： Article，,卷期：2010年120-6] Establishing long-term allograft acceptance without the requirement for continuous immunosuppression, a condition known as allograft tolerance, is a highly desirable therapeutic goal in solid organ transplantation. Deter... Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized mice [作者：Brightbill, HD; Jeet, S; Lin, ZH; Yan, DH; Zhou, MJ; Tan, M; Nguyen, A; Yeh, S; Delarosa, D; Leong, SR; Wong, T; Chen, Y; Ultsch, M; Luis, E; Ramani, SR; Jackman, J; Gonzalez, L; Dennis, MS; Chuntharapai, A; DeForge, L; Meng, YG; Xu, M; Eigenbrot, C; Lee, WP; Refino, CJ; Balazs, M; Wu, LC,期刊：Journal of clinical investigation, 页码：2218-2229 , 文章类型： Article，,卷期：2010年120-6] IgE-mediated hypersensitivity is central to the pathogenesis of asthma and other allergic diseases. Although neutralization of serum IgE with IgE-specific antibodies is in general an efficacious treatment for allergic as... Rapid T cell-based identification of human tumor tissue antigens by automated two-dimensional protein fractionation [作者：Beckhove, P; Warta, R; Lemke, B; Stoycheva, D; Momburg, F; Schnolzer, M; Warnken, U; Schmitz-Winnenthal, H; Ahmadi, R; Dyckhoff, G; Bucur, M; Junger, S; Schueler, T; Lennerz, V; Woelfel, T; Unterberg, A; Herold-Mende, C,期刊：Journal of clinical investigation, 页码：2230-2242 , 文章类型： Article，,卷期：2010年120-6] Identifying the antigens that have the potential to trigger endogenous antitumor responses in an individual cancer patient is likely to enhance the efficacy of cancer immunotherapy, but current methodologies do not effic... Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans [作者：Sagoo, P; Perucha, E; Sawitzki, B; Tomiuk, S; Stephens, DA; Miqueu, P; Chapman, S; Craciun, L; Sergeant, R; Brouard, S; Rovis, F; Jimenez, E; Ballow, A; Giral, M; Rebollo-Mesa, I; Le Moine, A; Braudeau, C; Hilton, R; Gerstmayer, B; Bourcier, K; Sharif, A; Krajewska, M; Lord, GM; Roberts, I; Goldman, M; Wood, KJ; Newell, K; Seyfert-Margolis, V; Warrens, AN; Janssen, U; Volk, HD; Soulillou, JP; Hernandez-Fuentes, MP; Lechler, RI,期刊：Journal of clinical investigation, 页码：1848-1861 , 文章类型： Article，,卷期：2010年120-6] Identifying transplant recipients in whom immunological tolerance is established or is developing would allow an individually tailored approach to their posttransplantation management. In this study, we aimed to develop ...