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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共42条记录   Location, location, location: important for jet-lagged circadian loops [作者：Harrington, M,期刊：Journal of clinical investigation, 页码：2265-2267 , 文章类型： Editorial Material，,卷期：2010年120-7] It is now believed that frequent jet lag or shifts of daily rhythms caused by rotating shift work can lead to deleterious health outcomes. Indeed, many serious health problems, including breast cancer, stroke, and cardio... An energetic tale of AMPK-independent effects of metformin [作者：Miller, RA; Birnbaum, MJ,期刊：Journal of clinical investigation, 页码：2267-2270 , 文章类型： Editorial Material，,卷期：2010年120-7] Metformin has become a mainstay in the modest therapeutic armamentarium for the treatment of the insulin resistance of type 2 diabetes mellitus. Although metformin functions primarily by reducing hepatic glucose output, ... Radioprotection: smart games with death [作者：Gudkov, AV; Komarova, EA,期刊：Journal of clinical investigation, 页码：2270-2273 , 文章类型： Editorial Material，,卷期：2010年120-7] The efficacy of cancer treatment by radiation and chemotherapeutic drugs is often limited by severe side effects that primarily affect the hematopoietic system and the epithelium of the gastrointestinal tract. Progress i... A balancing act for autophagin [作者：Till, A; Subramani, S,期刊：Journal of clinical investigation, 页码：2273-2276 , 文章类型： Editorial Material，,卷期：2010年120-7] Autophagy is a tightly regulated catabolic process whereby cells degrade their constituents to dispose of unwanted cytoplasmic elements and recycle nutrients for cellular remodeling. Studies of autophagy in mammals have ... Rapid progress for non-nuclear estrogen receptor signaling [作者：Mendelsohn, ME; Karas, RH,期刊：Journal of clinical investigation, 页码：2277-2279 , 文章类型： Editorial Material，,卷期：2010年120-7] Estrogen receptors are best known as ligand-activated transcription factors that regulate vascular cell gene expression. For many years now, a rapid signaling pathway mediated by cell membrane-associated estrogen recepto... GSK-3 alpha directly regulates beta-adrenergic signaling and the response of the heart to hemodynamic stress in mice [作者：Zhou, JB; Lal, H; Chen, XW; Shang, XY; Song, JL; Li, YX; Kerkela, R; Doble, BW; MacAulay, K; DeCaul, M; Koch, WJ; Farber, J; Woodgett, J; Gao, E; Force, T,期刊：Journal of clinical investigation, 页码：2280-2291 , 文章类型： Article，,卷期：2010年120-7] The glycogen synthase kinase-3 (GSK-3) family of serine/threonine kinases consists of 2 highly related isofortns, alpha and beta. Although GSK-3 beta has an important role in cardiac development, much remains unknown abo... Periostin advances atherosclerotic and rheumatic cardiac valve degeneration by inducing angiogenesis and MMP production in humans and rodents [作者：Hakuno, D; Kimura, N; Yoshioka, M; Mukai, M; Kimura, T; Okada, Y; Yozu, R; Shukunami, C; Hiraki, Y; Kudo, A; Ogawa, S; Fukuda, K,期刊：Journal of clinical investigation, 页码：2292-2306 , 文章类型： Article，,卷期：2010年120-7] Valvular heart disease (VHD) is the term given to any disease process involving one or more of the heart valves. The condition can be congenital or acquired, for example as a result of atherosclerosis or rheumatic fever.... Junb regulates arterial contraction capacity, cellular contractility, and motility via its target Myl9 in mice [作者：Licht, AH; Nubel, T; Feldner, A; Jurisch-Yaksi, N; Marcello, M; Demicheva, E; Hu, JH; Hartenstein, B; Augustin, HG; Hecker, M; Angel, P; Korff, T; Schorpp-Kistner, M,期刊：Journal of clinical investigation, 页码：2307-2318 , 文章类型： Article，,卷期：2010年120-7] Cellular contractility and, thus, the ability to alter cell shape are prerequisites for a number of important biological processes such as cytokinesis, movement, differentiation, and substrate adherence. The contractile ... Non-nuclear estrogen receptor alpha signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice [作者：Chambliss, KL; Wu, QA; Oltmann, S; Konaniah, ES; Umetani, M; Korach, KS; Thomas, GD; Mineo, C; Yuhanna, IS; Kim, SH; Madak-Erdogan, Z; Maggi, A; Dineen, SP; Roland, CL; Hui, DY; Brekken, RA; Katzenellenbogen, JA; Katzenellenbogen, BS; Shaul, PW,期刊：Journal of clinical investigation, 页码：2319-2330 , 文章类型： Article，,卷期：2010年120-7] Steroid hormone receptors function classically in the nucleus as transcription factors. However, recent data indicate that there are also non-nuclear subpopulations of steroid hormone receptors, including estrogen recept... Autophagy is essential for mouse sense of balance [作者：Marino, G; Fernandez, AF; Cabrera, S; Lundberg, YW; Cabanillas, R; Rodriguez, F; Salvador-Montoliu, N; Vega, JA; Germana, A; Fueyo, A; Freije, JMP; Lopez-Otin, C,期刊：Journal of clinical investigation, 页码：2331-2344 , 文章类型： Article，,卷期：2010年120-7] Autophagy is an evolutionarily conserved process that is essential for cellular homeostasis and organismal viability in eukaryotes. However, the extent of its functions in higher-order processes of organismal physiology ... Efficient and stable MGMT-mediated selection of long-term repopulating stem cells in nonhuman primates [作者：Beard, BC; Trobridge, GD; Ironside, C; McCune, JS; Adair, JE; Kiem, HP,期刊：Journal of clinical investigation, 页码：2345-2354 , 文章类型： Article，,卷期：2010年120-7] HSC transplantation using genetically modified autologous cells is a promising therapeutic strategy for various genetic diseases, cancer, and HIV. However, for many of these conditions, the current efficiency of gene tra... Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state [作者：Foretz, M; Hebrard, S; Leclerc, J; Zarrinpashneh, E; Soty, M; Mithieux, G; Sakamoto, K; Andreelli, F; Viollet, B,期刊：Journal of clinical investigation, 页码：2355-2369 , 文章类型： Article，,卷期：2010年120-7] Metformin is widely used to treat hyperglycemia in individuals with type 2 diabetes. Recently the LKB1/AMP-activated protein kinase (LKB1/AMPK) pathway was proposed to mediate the action of metformin on hepatic gluconeog... Alloantigen expression on non-hematopoietic cells reduces graft-versus-leukemia effects in mice [作者：Asakura, S; Hashimoto, D; Takashima, S; Sugiyama, H; Maeda, Y; Akashi, K; Tanimoto, M; Teshima, T,期刊：Journal of clinical investigation, 页码：2370-2378 , 文章类型： Article，,卷期：2010年120-7] Allogeneic hematopoietic stem cell transplantation (HSCT) is used effectively to treat a number of hematological malignancies. Its beneficial effects rely on donor-derived T cell-targeted leukemic cells, the so-called gr... Neuropilin-1 promotes cirrhosis of the rodent and human liver by enhancing PDGF/TGF-beta signaling in hepatic stellate cells [作者：Cao, S; Yaqoob, U; Das, A; Shergill, U; Jagavelu, K; Huebert, RC; Routray, C; Abdelmoneim, S; Vasdev, M; Leof, E; Charlton, M; Watts, RJ; Mukhopadhyay, D; Shah, VH,期刊：Journal of clinical investigation, 页码：2379-2394 , 文章类型： Article，,卷期：2010年120-7] PDGF-dependent hepatic stellate cell (HSC) recruitment is an essential step in liver fibrosis and the sinusoidal vascular changes that accompany this process. However, the mechanisms that regulate PDGF signaling remain i... Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice [作者：De Domenico, I; Zhang, TY; Koening, CL; Branch, RW; London, N; Lo, E; Daynes, RA; Kushner, JP; Li, D; Ward, DM; Kaplan, J,期刊：Journal of clinical investigation, 页码：2395-2405 , 文章类型： Article，,卷期：2010年120-7] Hepcidin is a peptide hormone that regulates iron homeostasis and acts as an antimicrobial peptide. It is expressed and secreted by a variety of cell types in response to iron loading and inflammation. Hepcidin mediates ... Hyperactivation of phosphatidylinositol-3 kinase promotes escape from hormone dependence in estrogen receptor-positive human breast cancer [作者：Miller, TW; Hennessy, BT; Gonzalez-Angulo, AM; Fox, EM; Mills, GB; Chen, HD; Higham, C; Garcia-Echeverria, C; Shyr, Y; Arteaga, CL,期刊：Journal of clinical investigation, 页码：2406-2413 , 文章类型： Article，,卷期：2010年120-7] Many breast cancers exhibit a degree of dependence on estrogen for tumor growth. Although several therapies have been developed to treat individuals with estrogen-dependent breast cancers, some tumors show de novo or acq...