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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共20条记录   How to blast osteoblasts? Novel dicarba analogues of amylin-(1-8) to treat osteoporosis [作者：KOWALCZYK RENATA; BRIMBLE MARGARET A; CALLON KAREN E; WATSON MAUREEN; CORNISH JILLIAN,期刊：Bioorganic & Medicinal Chemistry, 页码：6011-6018 , 文章类型： Article，,卷期：2012年20-20] When administered in vivo, amylin (1-8) stimulates osteoblast proliferation increasing bone volume and bone strength. The native cyclic octapeptide amylin (1-8) is unstable, however, it provides an attractive framework f... Identification and development of the 1,4-benzodiazepin-2-one and quinazoline-2,4-dione scaffolds as submicromolar inhibitors of HAT [作者：CLARK RACHEL L; CLEMENTS CAROL J; BARRETT MICHAEL P; MACKAY SIMON P; RATHNAM RAJENDRA P; OWUSUDAPAAH GEORGE; SPENCER JOHN; HUGGAN JUDITH K,期刊：Bioorganic & Medicinal Chemistry, 页码：6019-6033 , 文章类型： Article，,卷期：2012年20-20] A library of 1,4-benzodiazepines has been synthesised and evaluated for activity against Trypanosoma brucei, a causative parasite of Human African Trypanosomiasis (HAT). The most potent of these derivatives has an MIC va... RNA-based diagnosis in a multicellular specimen by whole mount in situ hybridization using an RNA-specific probe [作者：UEDA TAKAKO; KOBORI AKIO; YAMAYOSHI ASAKO; YOSHIDA HIDEKI; YAMAGUCHI MASAMITSU; MURAKAMI AKIRA,期刊：Bioorganic & Medicinal Chemistry, 页码：6034-6039 , 文章类型： Article，,卷期：2012年20-20] Recent RNA research has revealed the close involvement of various RNAs in cellular functions. RNAs are becoming the inevitable target molecules for research into details of gene expression. RNA and its related complexes ... Curcumin is an inhibitor of calcium/calmodulin dependent protein kinase II [作者：MAYADEVI M; SHERIN D R; KEERTHI V S; RAJASEKHARAN K N; OMKUMAR R V,期刊：Bioorganic & Medicinal Chemistry, 页码：6040-6047 , 文章类型： Article，,卷期：2012年20-20] Calcium/calmodulin dependent protein kinase II (CaMKII) is involved in the mechanisms underlying higher order brain functions such as learning and memory. CaMKII participates in pathological glutamate signaling also, sin... Design, modification and 3D QSAR studies of novel 2,3-dihydrobenzo[b][1,4]dioxin-containing 4,5-dihydro-1H-pyrazole derivatives as inhibitors of B-Raf kinase [作者：YANG YUSHUN; LI QINGSHAN; SUN SHUAI; ZHANG YANBIN; WANG XIAOLIANG; ZHANG FEI; TANG JIANFENG; ZHU HAILIANG,期刊：Bioorganic & Medicinal Chemistry, 页码：6048-6058 , 文章类型： Article，,卷期：2012年20-20] Two series of novel 2,3-dihydrobenzo[b][1,4]dioxin-containing 4,5-dihydro-1H-pyrazole derivatives C1-C15 and D1-D15 have been synthesized and evaluated for their B-Raf inhibitory and anti-proliferation activities. Compou... 'Inverted' analogs of the antibiotic gramicidin S with an improved biological profile [作者：KAPOERCHAN VARSHA V; KNIJNENBURG ANNEMIEK D; KEIZER PETER; SPALBURG EMILE; DE NEELING ALBERT J; MARSGROENENDIJK ROOS H; NOORT DAAN; OTERO JOSE M; LLAMASSAIZ ANTONIO L; VAN RAAIJ MARK J; VAN DER MAREL GIJS A; OVERKLEEFT HERMAN S; OVERHAND MARK,期刊：Bioorganic & Medicinal Chemistry, 页码：6059-6062 , 文章类型： Article，,卷期：2012年20-20] A series of gramicidin S derivatives 4-15 are presented that have four ornithine residues as polar protonated side chains and two central hydrophobic amino acids with unaltered turn regions. These peptides were screened ... Antitubercular nitrofuran isoxazolines with improved pharmacokinetic properties [作者：RAKESH; BRUHN DAVID; MADHURA DORA B; MADDOX MARCUS; LEE ROBIN B; TRIVEDI ASHIT; YANG LEI; SCHERMAN MICHAEL S; GILLILAND JANET C; GRUPPO VERONICA; MCNEIL MICHAEL R; LENAERTS ANNE J; MEIBOHM BERND; LEE RICHARD E,期刊：Bioorganic & Medicinal Chemistry, 页码：6063-6072 , 文章类型： Article，,卷期：2012年20-20] A series of tetracyclic nitrofuran isoxazoline anti-tuberculosis agents was designed and synthesized to improve the pharmacokinetic properties of an initial lead compound, which had potent anti-tuberculosis activity but ... Selection, synthesis, and anti-inflammatory evaluation of the arylidene malonate derivatives as TLR4 signaling inhibitors [作者：ZHANG SHUTING; CHENG KUI; WANG XIAOHUI; YIN HANG,期刊：Bioorganic & Medicinal Chemistry, 页码：6073-6079 , 文章类型： Article，,卷期：2012年20-20] Inhibition of TLR4 signaling is an important therapeutic strategy for intervention in the etiology of several pro-inflammatory diseases. There has been intensive research in recent years aiming to explore this strategy, ... Synthesis and CYP26A1 inhibitory activity of novel methyl 3-[4-(arylamino)phenyl]-3-(azole)-2,2-dimethylpropanoates [作者：GOMAA MOHAMED S; LIM ANDREW S T; LAU S C WILSON; WATTS ANNMARIE; ILLINGWORTH NICOLA A; BRIDGENS CAROLINE E; VEAL GARETH J; REDFERN CHRISTOPHER P F; BRANCALE ANDREA; ARMSTRONG JANE L; SIMONS CLAIRE,期刊：Bioorganic & Medicinal Chemistry, 页码：6080-6088 , 文章类型： Article，,卷期：2012年20-20] The role of all-trans-retinoic acid (ATRA) in the development and maintenance of many epithelial and neural tissues has raised great interest in the potential of ATRA and related compounds (retinoids) as pharmacological ... Synthesis, biological evaluation of novel 4,5-dihydro-2H-pyrazole 2-hydroxyphenyl derivatives as BRAF inhibitors [作者：LIU JIAJIA; ZHANG HUI; SUN JUAN; WANG ZHONGCHANG; YANG YUSHUN; LI DONGDONG; ZHANG FEI; GONG HAIBIN; ZHU HAILIANG,期刊：Bioorganic & Medicinal Chemistry, 页码：6089-6096 , 文章类型： Article，,卷期：2012年20-20] A series of novel 4,5-dihydropyrazole derivatives (3a-3t) containing hydroxyphenyl moiety as potential V600E mutant BRAF kinase (BRAF(V600E)) inhibitors were designed and synthesized. Docking simulation was performed to ... Synthesis and pharmacological investigation of azaphthalazinone human histamine H-1 receptor antagonists [作者：PROCOPIOU PANAYIOTIS A; BROWNING CHRISTOPHER; GORE PAUL M; LYNN SEAN M; RICHARDS STEPHEN A; SLACK ROBERT J; SOLLIS STEVEN L,期刊：Bioorganic & Medicinal Chemistry, 页码：6097-6108 , 文章类型： Article，,卷期：2012年20-20] 5-Aza, 6-aza, 7-aza and 8-aza-phthalazinone, and 5,8-diazaphthalazinone templates were synthesised by stereoselective routes starting from the appropriate pyridine/pyrazine dicarboxylic acids by activation with CDI, reac... Structure-activity relationship study of nitrosopyrimidines acting as antifungal agents [作者：OLIVELLA MONICA; MARCHAL ANTONIO; NOGUERAS MANUEL; SANCHEZ ADOLFO; MELGUIZO MANUEL; RAIMONDI MARCELA; ZACCHINO SUSANA; GIANNINI FERNANDO; COBO JUSTO; ENRIZ RICARDO D,期刊：Bioorganic & Medicinal Chemistry, 页码：6109-6122 , 文章类型： Article，,卷期：2012年20-20] The design, synthesis, in vitro evaluation, and conformational study of nitrosopyrimidine derivatives acting as antifungal agents are reported. Different compounds structurally related with 4,6-bis(alkyl or arylamino)-5-... Synthesis and antiviral activity of 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides [作者：TICHY MICHAL; POHL RADEK; XU HAO YING; CHEN YENLIANG; YOKOKAWA FUMIAKI; SHI PEIYONG; HOCEK MICHAL,期刊：Bioorganic & Medicinal Chemistry, 页码：6123-6133 , 文章类型： Article，,卷期：2012年20-20] A series of new pyrimido[4,5-b]indole ribonucleosides bearing phenyl or hetaryl group at position 4 has been prepared by selective Pd-catalyzed cross-coupling reactions of the corresponding protected 4,6-dichloropyrimido... Minutissamides E-L, antiproliferative cyclic lipodecapeptides from the cultured freshwater cyanobacterium cf. Anabaena sp. [作者：KANG HAHKSOO; STURDY MEGAN; KRUNIC ALEKSEJ; KIM HYUNJUNG; SHEN QI; SWANSON STEVEN M; ORJALA JIMMY,期刊：Bioorganic & Medicinal Chemistry, 页码：6134-6143 , 文章类型： Article，,卷期：2012年20-20] The extract of UIC 10035, a strain obtained from a sample collected near the town of Homestead, South Florida, showed antiproliferative activity against MDA-MB-435 cells. Bioassay-guided fractionation led to the isolatio... Development of erlotinib derivatives as CIP2A-ablating agents independent of EGFR activity [作者：CHEN KUENFENG; PAO KUANCHUAN; SU JUNGCHEN; CHOU YICHIEH; LIU CHUNYU; CHEN HUIJU; HUANG JUIWEN; KIM INKI; SHIAU CHUNGWAI,期刊：Bioorganic & Medicinal Chemistry, 页码：6144-6153 , 文章类型： Article，,卷期：2012年20-20] Cancerous inhibitor of PP2A (CIP2A) is a novel human oncoprotein that inhibits PP2A, contributing to tumor aggressiveness in various cancers. Several studies have shown that downregulation of CIP2A by small molecules red... Novel fluorescent ceramide derivatives for probing ceramidase substrate specificity [作者：BHABAK KRISHNA P; PROKSCH DENNY; REDMER SUSANNE; ARENZ CHRISTOPH,期刊：Bioorganic & Medicinal Chemistry, 页码：6154-6161 , 文章类型： Article，,卷期：2012年20-20] Ceramidases are key regulators of cell fate. The biochemistry of different ceramidases and of their substrate ceramide appears to be complex, mainly due to specific biophysical characteristics at the water-membrane inter...