- Rab35 Controls Actin Bundling by Recruiting Fascin as an Effector Protein
[作者：Zhang, J; Fonovic, M; Suyama, K; Bogyo, M; Scott, MP,期刊：Science, 页码：1250-1254 , 文章类型： Article，,卷期：2009年325-5945]
- Actin filaments are key components of the eukaryotic cytoskeleton that provide mechanical structure and generate forces during cell shape changes, growth, and migration. Actin filaments are dynamically assembled into hig...
- Positive Interactions Promote Public Cooperation
[作者：Rand, DG; Dreber, A; Ellingsen, T; Fudenberg, D; Nowak, MA,期刊：Science, 页码：1272-1275 , 文章类型： Article，,卷期：2009年325-5945]
- The public goods game is the classic laboratory paradigm for studying collective action problems. Each participant chooses how much to contribute to a common pool that returns benefits to all participants equally. The id...
- Differential Sensitivity to Human Communication in Dogs, Wolves, and Human Infants
[作者：Topal, J; Gergely, G; Erdohegyi, A; Csibra, G; Miklosi, A,期刊：Science, 页码：1269-1272 , 文章类型： Article，,卷期：2009年325-5945]
- Ten-month-old infants persistently search for a hidden object at its initial hiding place even after observing it being hidden at another location. Recent evidence suggests that communicative cues from the experimenter c...
- Recruitment of Antigen-Specific CD8(+) T Cells in Response to Infection Is Markedly Efficient
[作者：van Heijst, JWJ; Gerlach, C; Swart, E; Sie, D; Nunes-Alves, C; Kerkhoven, RM; Arens, R; Correia-Neves, M; Schepers, K; Schumacher, TNM,期刊：Science, 页码：1265-1269 , 文章类型： Article，,卷期：2009年325-5945]
- The magnitude of antigen-specific CD8(+) T cell responses is not fixed but correlates with the severity of infection. Although by definition T cell response size is the product of both the capacity to recruit naive T cel...
- Activation of the PI3K Pathway in Cancer Through Inhibition of PTEN by Exchange Factor P-REX2a
[作者：Fine, B; Hodakoski, C; Koujak, S; Su, T; Saal, LH; Maurer, M; Hopkins, B; Keniry, M; Sulis, ML; Mense, S; Hibshoosh, H; Parsons, R,期刊：Science, 页码：1261-1265 , 文章类型： Article，,卷期：2009年325-5945]
- PTEN (phosphatase and tensin homolog on chromosome 10) is a tumor suppressor whose cellular regulation remains incompletely understood. We identified phosphatidylinositol 3,4,5-trisphosphate RAC exchanger 2a (P-REX2a) as...
- Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate
[作者：Hait, NC; Allegood, J; Maceyka, M; Strub, GM; Harikumar, KB; Singh, SK; Luo, C; Marmorstein, R; Kordula, T; Milstien, S; Spiegel, S,期刊：Science, 页码：1254-1257 , 文章类型： Article，,卷期：2009年325-5945]
- The pleiotropic lipid mediator sphingosine-1-phosphate (S1P) can act intracellularly independently of its cell surface receptors through unknown mechanisms. Sphingosine kinase 2 (SphK2), one of the isoenzymes that genera...
- Common Regulatory Variation Impacts Gene Expression in a Cell Type-Dependent Manner
[作者：Dimas, AS; Deutsch, S; Stranger, BE; Montgomery, SB; Borel, C; Attar-Cohen, H; Ingle, C; Beazley, C; Arcelus, MG; Sekowska, M; Gagnebin, M; Nisbett, J; Deloukas, P; Dermitzakis, ET; Antonarakis, SE,期刊：Science, 页码：1246-1250 , 文章类型： Article，,卷期：2009年325-5945]
- Studies correlating genetic variation to gene expression facilitate the interpretation of common human phenotypes and disease. As functional variants may be operating in a tissue-dependent manner, we performed gene expre...
- Fundamental Evolutionary Limits in Ecological Traits Drive Drosophila Species Distributions
[作者：Kellermann, V; van Heerwaarden, B; Sgro, CM; Hoffmann, AA,期刊：Science, 页码：1244-1246 , 文章类型： Article，,卷期：2009年325-5945]
- Species that are habitat specialists make up much of biodiversity, but the evolutionary factors that limit their distributions have rarely been considered. We show that in Drosophila, narrow and wide ranges of desiccatio...
- Poly(ADP-ribose)-Dependent Regulation of DNA Repair by the Chromatin Remodeling Enzyme ALC1
[作者：Ahel, D; Horejsi, Z; Wiechens, N; Polo, SE; Garcia-Wilson, E; Ahel, I; Flynn, H; Skehel, M; West, SC; Jackson, SP; Owen-Hughes, T; Boulton, SJ,期刊：Science, 页码：1240-1243 , 文章类型： Article，,卷期：2009年325-5945]
- Posttranslational modifications play key roles in regulating chromatin plasticity. Although various chromatin-remodeling enzymes have been described that respond to specific histone modifications, little is known about t...
- Recent Warming Reverses Long-Term Arctic Cooling
[作者：Kaufman, DS; Schneider, DP; McKay, NP; Ammann, CM; Bradley, RS; Briffa, KR; Miller, GH; Otto-Bliesner, BL; Overpeck, JT; Vinther, BM,期刊：Science, 页码：1236-1239 , 文章类型： Article，,卷期：2009年325-5945]
- The temperature history of the first millennium C. E. is sparsely documented, especially in the Arctic. We present a synthesis of decadally resolved proxy temperature records from poleward of 60 degrees N covering the pa...
- Reassessing the Source of Long-Period Comets
[作者：Kaib, NA; Quinn, T,期刊：Science, 页码：1234-1236 , 文章类型： Article，,卷期：2009年325-5945]
- We present numerical simulations to model the production of observable long-period comets (LPCs) from the Oort Cloud, a vast reservoir of icy bodies surrounding the Sun. We show that inner Oort Cloud objects can penetrat...
- A Sulfilimine Bond Identified in Collagen IV
[作者：Vanacore, R; Ham, AJL; Voehler, M; Sanders, CR; Conrads, TP; Veenstra, TD; Sharpless, KB; Dawson, PE; Hudson, BG,期刊：Science, 页码：1230-1234 , 文章类型： Article，,卷期：2009年325-5945]
- Collagen IV networks are ancient proteins of basement membranes that underlie epithelia in metazoa from sponge to human. The networks provide structural integrity to tissues and serve as ligands for integrin cell-surface...
- Complete Methods Set for Scalable Ion Trap Quantum Information Processing
[作者：Home, JP; Hanneke, D; Jost, JD; Amini, JM; Leibfried, D; Wineland, DJ,期刊：Science, 页码：1227-1230 , 文章类型： Article，,卷期：2009年325-5945]
- Large-scale quantum information processors must be able to transport and maintain quantum information and repeatedly perform logical operations. Here, we show a combination of all of the fundamental elements required to ...
- Realization of an Excited, Strongly Correlated Quantum Gas Phase
[作者：Haller, E; Gustavsson, M; Mark, MJ; Danzl, JG; Hart, R; Pupillo, G; Nagerl, HC,期刊：Science, 页码：1224-1227 , 文章类型： Article，,卷期：2009年325-5945]
- Ultracold atomic physics offers myriad possibilities to study strongly correlated many-body systems in lower dimensions. Typically, only ground-state phases are accessible. Using a tunable quantum gas of bosonic cesium a...
- An Ultramassive, Fast-Spinning White Dwarf in a Peculiar Binary System
[作者：Mereghetti, S; Tiengo, A; Esposito, P; La Palombara, N; Israel, GL; Stella, L,期刊：Science, 页码：1222-1223 , 文章类型： Article，,卷期：2009年325-5945]
- White dwarfs typically have masses in a narrow range centered at about 0.6 solar mass (M-circle dot). Only a few ultramassive white dwarfs (mass > 1.2 M-circle dot) are known. Those in binary systems are of particular in...
- Perineuronal Nets Protect Fear Memories from Erasure
[作者：Gogolla, N; Caroni, P; Luthi, A; Herry, C,期刊：Science, 页码：1258-1261 , 文章类型： Article，,卷期：2009年325-5945]
- In adult animals, fear conditioning induces a permanent memory that is resilient to erasure by extinction. In contrast, during early postnatal development, extinction of conditioned fear leads to memory erasure, suggesti...
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