In the field of pharmacogenomics, genetic information is utilized to explain variations in drug response between individuals. In many instances, information on single nucleotide polymorphisms (SNPs) of genes encoding ...
Minimizing the potential for drug candidates to form chemically reactive metabolites that can covalently modify cellular macromolecules represents a rational strategy to reduce the risk of drug-induced idiosyncratic t...
A contemporary understanding of the clinical aspects of drug-induced liver injury (DILI) is paramount for timely diagnosis and appropriate management. An accurate diagnosis of DILI is based upon a combination of appro...
Drug-induced kidney injury is a serious and not uncommon adverse event which needs to be considered during drug development. The current standards used to monitor kidney function, such as blood urea nitrogen and serum...
The sulfonamide group is widely used in medicinal chemistry and appears in many marketed drugs in a variety of forms. One class of drugs that contain this group has been termed the 'sulfonamide antibacterials'. These ...
The number of new drugs that reach the market is declining every year, and, in recent years, several drugs already on the market have been withdrawn because of safety concerns. In response to this, the pharmaceutical ...
Molecular pathway and network analysis tools that have been developed over the past decade provide an emerging systems-wide perspective for the analysis of gene expression, proteomic and metabolomic data. These tools ...
Positron emission tomography (PET) imaging using microdoses of radiolabeled drug tracers is gaining increasing acceptance in modern clinical drug development. This approach is unique in that it allows for direct quant...
Cell culture plays a fundamental role in the biotechnology and pharmaceutical industries, impacting both drug discovery and manufacturing as well as regenerative medicine. In drug discovery, cell-based assays are incr...
A number of drug withdrawals in recent years have been related to cardiovascular toxicity associated with undesirable blockade of the hERG potassium channel. A promiscuous target, hERG has been demonstrated to interac...