- Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor
[作者：Daigle, SR; Olhava, EJ; Therkelsen, CA; Majer, CR; Sneeringer, CJ; Song, J; Johnston, LD; Scott, MP; Smith, JJ; Xiao, YH; Jin, L; Kuntz, KW; Chesworth, R; Moyer, MP; Bernt, KM; Tseng, JC; Kung, AL; Armstrong, SA; Copeland, RA; Richon, VM; Pollock, RM,期刊：Cancer Cell, 页码：53-65 , 文章类型： Article，,卷期：2011年20-1]
- Mislocated enzymatic activity of DOT1L has been proposed as a driver of leukemogenesis in mixed lineage leukemia (MLL). The characterization of EPZ004777, a potent, selective inhibitor of DOT1L is reported. Treatment of ...
- MLL-Rearranged Leukemia Is Dependent on Aberrant H3K79 Methylation by DOT1L
[作者：Bernt, KM; Zhu, N; Sinha, AU; Vempati, S; Faber, J; Krivtsov, AV; Feng, ZH; Punt, N; Daigle, A; Bullinger, L; Pollock, RM; Richon, VM; Kung, AL; Armstrong, SA,期刊：Cancer Cell, 页码：66-78 , 文章类型： Article，,卷期：2011年20-1]
- The histone 3 lysine 79 (H3K79) methyltransferase Dot1l has been implicated in the development of leukemias bearing translocations of the Mixed Lineage Leukemia (MLL) gene. We identified the MLL-fusion targets in an MLL-...
- A Pin1/Mutant p53 Axis Promotes Aggressiveness in Breast Cancer
[作者：Girardini, JE; Napoli, M; Piazza, S; Rustighi, A; Marotta, C; Radaelli, E; Capaci, V; Jordan, L; Quinlan, P; Thompson, A; Mano, M; Rosato, A; Crook, T; Scanziani, E; Means, AR; Lozano, G; Schneider, C; Del Sal, G,期刊：Cancer Cell, 页码：79-91 , 文章类型： Article，,卷期：2011年20-1]
- TP53 missense mutations dramatically influence tumor progression, however, their mechanism of action is still poorly understood. Here we demonstrate the fundamental role of the prolyl isomerase Pin1 in mutant p53 oncogen...
- Proinvasion Metastasis Drivers in Early-Stage Melanoma Are Oncogenes
[作者：Scott, KL; Nogueira, C; Heffernan, TP; van Doorn, R; Dhakal, S; Hanna, JA; Min, CY; Jaskelioff, M; Xiao, YH; Wu, CJ; Cameron, LA; Perry, SR; Zeid, R; Feinberg, T; Kim, M; Vande Woude, G; Granter, SR; Bosenberg, M; Chu, GC; DePinho, RA; Rimm, DL; Chin, L,期刊：Cancer Cell, 页码：92-103 , 文章类型： Article，,卷期：2011年20-1]
- Clinical and genomic evidence suggests that the metastatic potential of a primary tumor may be dictated by prometastatic events that have additional oncogenic capability. To test this "deterministic" hypothesis, we adopt...
- miR-30b/30d Regulation of GaINAc Transferases Enhances Invasion and Immunosuppression during Metastasis
[作者：Gaziel-Sovran, A; Segura, MF; Di Micco, R; Collins, MK; Hanniford, D; de Miera, EVS; Rakus, JF; Dankert, JF; Shang, SL; Kerbel, RS; Bhardwaj, N; Shao, YZ; Darvishian, F; Zavadil, J; Erlebacher, A; Mahal, LK; Osman, I; Hernando, E,期刊：Cancer Cell, 页码：104-118 , 文章类型： Article，,卷期：2011年20-1]
- To metastasize, a tumor cell must acquire abilities such as the capacity to colonize new tissue and evade immune surveillance. Recent evidence suggests that microRNAs can promote the evolution of malignant behaviors by r...
- Targeting Androgen Receptor in Estrogen Receptor-Negative Breast Cancer
[作者：Ni, M; Chen, YW; Lim, E; Wimberly, H; Bailey, ST; Imai, Y; Rimm, DL; Liu, XS; Brown, M,期刊：Cancer Cell, 页码：119-131 , 文章类型： Article，,卷期：2011年20-1]
- Endocrine therapies for breast cancer that target the estrogen receptor (ER) are ineffective in the 25%-30% of cases that are ER negative (ER-). Androgen receptor (AR) is expressed in 60%-70% of breast tumors, independen...
- Tet2 Loss Leads to Increased Hematopoietic Stem Cell Self-Renewal and Myeloid Transformation
[作者：Moran-Crusio, K; Reavie, L; Shih, A; Abdel-Wahab, O; Ndiaye-Lobry, D; Lobry, C; Figueroa, ME; Vasanthakumar, A; Patel, J; Zhao, XY; Perna, F; Pandey, S; Madzo, J; Song, CX; Dai, Q; He, C; Ibrahim, S; Beran, M; Zavadil, J; Nimer, SD; Melnick, A; Godley, LA; Aifantis, I; Levine, RL,期刊：Cancer Cell, 页码：11-24 , 文章类型： Article，,卷期：2011年20-1]
- Somatic loss-of-function mutations in the ten-eleven translocation 2 (TET2) gene occur in a significant proportion of patients with myeloid malignancies. Although there are extensive genetic data implicating TET2 mutatio...
- TET2 Inactivation Results in Pleiotropic Hematopoietic Abnormalities in Mouse and Is a Recurrent Event during Human Lymphomagenesis
[作者：Quivoron, C; Couronne, L; Della Valle, V; Lopez, CK; Plo, I; Wagner-Ballon, O; Do Cruzeiro, M; Delhommeau, F; Arnulf, B; Stern, MH; Godley, L; Opolon, P; Tilly, H; Solary, E; Duffourd, Y; Dessen, P; Merle-Beral, H; Florence, NK; Fontenay, M; Vainchenker, W; Bastard, C; Mercher, T; Bernard, OA,期刊：Cancer Cell, 页码：25-38 , 文章类型： Article，,卷期：2011年20-1]
- Loss-of-function mutations affecting one or both copies of the Ten-Eleven-translocation (TET)2 gene have been described in various human myeloid malignancies. We report that inactivation of Tet2 in mouse perturbs both ea...
- Cell of Origin in AML: Susceptibility to MN1-Induced Transformation Is Regulated by the MEIS1/AbdB-like HOX Protein Complex
[作者：Heuser, M; Yun, HY; Berg, T; Yung, E; Argiropoulos, B; Kuchenbauer, F; Park, G; Hamwi, I; Palmqvist, L; Lai, CK; Leung, M; Lin, G; Chaturvedi, A; Thakur, BK; Iwasaki, M; Bilenky, M; Thiessen, N; Robertson, G; Hirst, M; Kent, D; Wilson, NK; Gottgens, B; Eaves, C; Cleary, ML; Marra, M; Ganser, A; Humphries, RK,期刊：Cancer Cell, 页码：39-52 , 文章类型： Article，,卷期：2011年20-1]
- Pathways defining susceptibility of normal cells to oncogenic transformation may be valuable therapeutic targets. We characterized the cell of origin and its critical pathways in MN1-induced leukemias. Common myeloid (CM...
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