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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共16条记录   Polarization of Tumor-Associated Macrophages: A Novel Strategy for Vascular Normalization and Antitumor Immunity [作者：Huang, YH; Snuderl, M; Jain, RK,期刊：Cancer Cell, 页码：1-2 , 文章类型： Editorial Material，,卷期：2011年19-1] Vascular normalization is an emerging concept in cancer treatment. In this issue of Cancer Cell, Rolny et al. show that histidine-rich glycoprotein normalizes tumor vessels and promotes antitumor immunity by polarizing t... Hard Times for Oncogenic BRAF-Expressing Melanoma Cells [作者：Houslay, MD,期刊：Cancer Cell, 页码：3-4 , 文章类型： Editorial Material，,卷期：2011年19-1] In this issue of Cancer Cell, Arozarena et al. describe that the oncogenic BRAF Va1600Glu mutant, which occurs in about half of melanomas, downregulates the cGMP-hydrolysing phosphodiesterase PDE5A in melanoma cells thro... Keratin 15-Positive Stem Cells Give Rise to Basal Cell Carcinomas in Irradiated Ptch1(+/-) Mice [作者：Seykora, JT; Cotsarelis, G,期刊：Cancer Cell, 页码：5-6 , 文章类型： Editorial Material，,卷期：2011年19-1] The cell of origin for basal cell carcinoma (BCC) remains controversial. In this issue of Cancer Cell, Wang et al. provide strong evidence that BCC arise from hair follicle stem cells. Metastatic Colon Cancer Cells Negotiate the Intravasation Notch [作者：Christofori, G,期刊：Cancer Cell, 页码：6-8 , 文章类型： Editorial Material，,卷期：2011年19-1] In this issue of Cancer Cell, Sonoshita et al. report that Aes/Grg5 prevents metastasis of colorectal cancer cells by sequestering and inactivating Notch transcriptional effectors in distinct nuclear foci. Loss of Aes/Gr... Human Acute Myelogenous Leukemia Stem Cells Revisited: There's More Than Meets the Eye [作者：Majeti, R; Weissman, IL,期刊：Cancer Cell, 页码：9-10 , 文章类型： Editorial Material，,卷期：2011年19-1] In this issue of Cancer Cell, Goardon et al. revise earlier conclusions regarding acute myelogenous leukemia (AML) stern cells by demonstrating that in the majority of patients, they reside in two hierarchically related ... Mutant BRAF Melanomas-Dependence and Resistance [作者：Poulikakos, PI; Rosen, N,期刊：Cancer Cell, 页码：11-15 , 文章类型： Review，,卷期：2011年19-1] RAF inhibitors have the unique property of transactivating RAS-dependent RAF dimers in most cells but inhibit RAF/MEK/ERK signaling in cells expressing mutant BRAF, in which RAS activity is too low to support this proces... Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of alpha-Ketoglutarate-Dependent Dioxygenases [作者：Xu, W; Yang, H; Liu, Y; Yang, Y; Wang, P; Kim, SH; Ito, S; Yang, C; Wang, P; Xiao, MT; Liu, LX; Jiang, WQ; Liu, J; Zhang, JY; Wang, B; Frye, S; Zhang, Y; Xu, YH; Lei, QY; Guan, KL; Zhao, SM; Xiong, Y,期刊：Cancer Cell, 页码：17-30 , 文章类型： Article，,卷期：2011年19-1] 1DH1 and 1DH2 mutations occur frequently in gliomas and acute myeloid leukemia, leading to simultaneous loss and gain of activities in the production of alpha-ketoglutarate (alpha-KG) and 2-hydroxyglutarate (2-HG), respe... HRG Inhibits Tumor Growth and Metastasis by Inducing Macrophage Polarization and Vessel Normalization through Downregulation of PIGF [作者：Rolny, C; Mazzone, M; Tugues, S; Laoui, D; Johansson, I; Coulon, C; Squadrito, ML; Segura, I; Li, XJ; Knevels, E; Costa, S; Vinckier, S; Dresselaer, T; Akerud, P; De Mol, M; Salomaki, H; Phillipson, M; Wyns, S; Larsson, E; Buysschaert, I; Botling, J; Himmelreich, U; Van Ginderachter, JA; De Palma, M; Dewerchin, M; Claesson-Welsh, L; Carmeliet, P,期刊：Cancer Cell, 页码：31-44 , 文章类型： Article，,卷期：2011年19-1] Polarization of tumor-associated macrophages (TAMs) to a proangiogenic/immune-suppressive (M2-like) phenotype and abnormal, hypoperfused vessels are hallmarks of malignancy, but their molecular basis and interrelationshi... Oncogenic BRAF Induces Melanoma Cell Invasion by Downregulating the cGMP-Specific Phosphodiesterase PDE5A [作者：Arozarena, I; Sanchez-Laorden, B; Packer, L; Hidalgo-Carcedo, C; Hayward, R; Viros, A; Sahai, E; Marais, R,期刊：Cancer Cell, 页码：45-57 , 文章类型： Article，,卷期：2011年19-1] We show that in melanoma cells oncogenic BRAF, acting through MEK and the transcription factor BRN2, downregulates the cGMP-specific phosphodiesterase PDE5A. Although PDE5A downregulation causes a small decrease in proli... AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity [作者：Chandarlapaty, S; Sawai, A; Scaltriti, M; Rodrik-Outmezguine, V; Grbovic-Huezo, O; Serra, V; Majumder, PK; Baselga, J; Rosen, N,期刊：Cancer Cell, 页码：58-71 , 文章类型： Article，,卷期：2011年19-1] Activation of the PI3K-AKT pathway in tumors is modulated by negative feedback, including mTORC1-mediated inhibition of upstream signaling. We now show that AKT inhibition induces the expression and phosphorylation of mu... Endogenous T Cell Responses to Antigens Expressed in Lung Adenocarcinomas Delay Malignant Tumor Progression [作者：DuPage, M; Cheung, AF; Mazumdar, C; Winslow, MM; Bronson, R; Schmidt, LM; Crowley, D; Chen, JZ; Jacks, T,期刊：Cancer Cell, 页码：72-85 , 文章类型： Article，,卷期：2011年19-1] Neoantigens derived from somatic mutations in tumors may provide a critical link between the adaptive immune system and cancer. Here, we describe a system to introduce exogenous antigens into genetically engineered mouse... EZH2 Promotes Expansion of Breast Tumor Initiating Cells through Activation of RAF1-beta-Catenin Signaling [作者：Chang, CJ; Yang, JY; Xia, WY; Chen, CT; Xie, XM; Chao, CH; Woodward, WA; Hsu, JM; Hortobagyi, GN; Hung, MC,期刊：Cancer Cell, 页码：86-100 , 文章类型： Article，,卷期：2011年19-1] It has been proposed that an aggressive secondary cancer stem cell population arises from a primary cancer stem cell population through acquisition of additional genetic mutations and drives cancer progression. Overexpre... An Fc gamma Receptor-Dependent Mechanism Drives Antibody-Mediated Target-Receptor Signaling in Cancer Cells [作者：Wilson, NS; Yang, B; Yang, A; Loeser, S; Marsters, S; Lawrence, D; Li, Y; Pitti, R; Totpal, K; Yee, S; Ross, S; Vernes, JM; Lu, YM; Adams, C; Offringa, R; Kelley, B; Hymowitz, S; Daniel, D; Meng, G; Ashkenazi, A,期刊：Cancer Cell, 页码：101-113 , 文章类型： Article，,卷期：2011年19-1] Antibodies to cell-surface antigens trigger activatory Fc gamma receptor (Fc gamma R)-mediated retrograde signals in leukocytes to control immune effector functions. Here, we uncover an Fc gamma R mechanism that drives a... Basal Cell Carcinomas Arise from Hair Follicle Stem Cells in Ptch1(+/-) Mice [作者：Wang, GY; Wang, J; Mancianti, ML; Epstein, EH,期刊：Cancer Cell, 页码：114-124 , 文章类型： Article，,卷期：2011年19-1] Basal cell carcinomas (BCCs) are hedgehog-driven tumors that resemble follicular and interfollicular epidermal basal keratinocytes and hence long have been thought to arise from these cells. However, the actual cell of o... Suppression of Colon Cancer Metastasis by Aes through Inhibition of Notch Signaling [作者：Sonoshita, M; Aoki, M; Fuwa, H; Aoki, K; Hosogi, H; Sakai, Y; Hashida, H; Takabayashi, A; Sasaki, M; Robine, S; Itoh, K; Yoshioka, K; Kakizaki, F; Kitamura, T; Oshima, M; Taketo, MM,期刊：Cancer Cell, 页码：125-137 , 文章类型： Article，,卷期：2011年19-1] Metastasis is responsible for most cancer deaths. Here, we show that Aes (or Grg5) gene functions as an endogenous metastasis suppressor. Expression of Aes was decreased in liver metastases compared with primary colon tu... Coexistence of LMPP-like and GMP-like Leukemia Stem Cells in Acute Myeloid Leukemia [作者：Goardon, N; Marchi, E; Atzberger, A; Quek, L; Schuh, A; Soneji, S; Woll, P; Mead, A; Alford, KA; Rout, R; Chaudhury, S; Gilkes, A; Knapper, S; Beldjord, K; Begum, S; Rose, S; Geddes, N; Griffiths, M; Standen, G; Sternberg, A; Cavenagh, J; Hunter, H; Bowen, D; Killick, S; Robinson, L; Price, A; Macintyre, E; Virgo, P; Burnett, A; Craddock, C; Enver, T; Jacobsen, SEW; Porcher, C; Vyas, P,期刊：Cancer Cell, 页码：138-152 , 文章类型： Article，,卷期：2011年19-1] The relationships between normal and leukemic stem/progenitor cells are unclear. We show that in similar to 80% of primary human CD34(+) acute myeloid leukemia (AML), two expanded populations with hemopoietic progenitor ...