- NEDD8 Pathways in Cancer, Sine Quibus Non
[作者：Watson, IR; Irwin, MS; Ohh, M,期刊：Cancer Cell, 页码：168-176 , 文章类型： Review，,卷期：2011年19-2]
- There are 17 known ubiquitin-like proteins (UBLs) from nine phylogenetically distinct classes (NEDD8, SUMO, ISG15, FUB1, FAT10, Atg8, Atg12, Urm1, and UFM1) that have been identified to conjugate to substrates in a manne...
- Evidence for an Unanticipated Relationship between Undifferentiated Pleomorphic Sarcoma and Embryonal Rhabdomyosarcoma
[作者：Rubin, BP; Nishijo, K; Chen, HIH; Yi, XL; Schuetze, DP; Pal, R; Prajapati, SI; Abraham, J; Arenkiel, BR; Chen, QR; Davis, S; McCleish, AT; Capecchi, MR; Michalek, JE; Zarzabal, LA; Khan, J; Yu, ZX; Parham, DM; Barr, FG; Meltzer, PS; Chen, YD; Keller, C,期刊：Cancer Cell, 页码：177-191 , 文章类型： Article，,卷期：2011年19-2]
- Embryonal rhabdomyosarcoma (eRMS) shows the most myodifferentiation among sarcomas, yet the precise cell of origin remains undefined. Using Ptch1, p53 and/or Rb1 conditional mouse models and controlling prenatal or postn...
- Tumor-Derived Jagged1 Promotes Osteolytic Bone Metastasis of Breast Cancer by Engaging Notch Signaling in Bone Cells
[作者：Sethi, N; Dai, XD; Winter, CG; Kang, YB,期刊：Cancer Cell, 页码：192-205 , 文章类型： Article，,卷期：2011年19-2]
- Despite evidence supporting an oncogenic role in breast cancer, the Notch pathway's contribution to metastasis remains unknown. Here, we report that the Notch ligand Jagged1 is a clinically and functionally important med...
- Early Relapse in ALL Is Identified by Time to Leukemia in NOD/SCID Mice and Is Characterized by a Gene Signature Involving Survival Pathways
[作者：Meyer, LH; Eckhoff, SM; Queudeville, M; Kraus, JM; Giordan, M; Stursberg, J; Zangrando, A; Vendramini, E; Moricke, A; Zimmermann, M; Schrauder, A; Lahr, G; Holzmann, K; Schrappe, M; Basso, G; Stahnke, K; Kestler, HA; Kronnie, GT; Debatin, KM,期刊：Cancer Cell, 页码：206-217 , 文章类型： Article，,卷期：2011年19-2]
- We investigated the engraftment properties and impact on patient outcome of 50 pediatric acute lymphoblastic leukemia (ALL) samples transplanted into NOD/SCID mice. Time to leukemia (TTL) was determined for each patient ...
- N-alpha-Acetyltransferase 10 Protein Suppresses Cancer Cell Metastasis by Binding PIX Proteins and Inhibiting Cdc42/Rac1 Activity
[作者：Hua, KT; Tan, CT; Johansson, G; Lee, JM; Yang, PW; Lu, HY; Chen, CK; Su, JL; Chen, PB; Wu, YL; Chi, CC; Kao, HJ; Shih, HJ; Chen, MW; Chien, MH; Chen, PS; Lee, WJ; Cheng, TY; Rosenberger, G; Chai, CY; Yang, CJ; Huang, MS; Lai, TC; Chou, TY; Hsiao, M; Kuo, ML,期刊：Cancer Cell, 页码：218-231 , 文章类型： Article，,卷期：2011年19-2]
- N-alpha-acetyltransferase 10 protein, Naa10p, is an N-acetyltransferase known to be involved in cell cycle control. We found that Naa10p was expressed lower in varieties of malignancies with lymph node metastasis compare...
- Identification of miRNomes in Human Liver and Hepatocellular Carcinoma Reveals miR-199a/b-3p as Therapeutic Target for Hepatocellular Carcinoma
[作者：Hou, J; Lin, L; Zhou, WP; Wang, ZX; Ding, GS; Dong, QZ; Qin, LX; Wu, XB; Zheng, YY; Yang, Y; Tian, W; Zhang, QA; Wang, CM; Zhang, QH; Zhuang, SM; Zheng, LM; Liang, AM; Tao, WZ; Cao, XT,期刊：Cancer Cell, 页码：232-243 , 文章类型： Article，,卷期：2011年19-2]
- The full scale of human miRNome in specific cell or tissue, especially in cancers, remains to be determined. An in-depth analysis of miRNomes in human normal liver, hepatitis liver, and hepatocellular carcinoma (HCC) was...
- A Functional Role for Tumor Cell Heterogeneity in a Mouse Model of Small Cell Lung Cancer
[作者：Calbo, J; van Montfort, E; Proost, N; van Drunen, E; Beverloo, HB; Meuwissen, R; Berns, A,期刊：Cancer Cell, 页码：244-256 , 文章类型： Article，,卷期：2011年19-2]
- Small cell lung cancer (SCLC) is the lung neoplasia with the poorest prognosis, due to its high metastatic potential and chemoresistance upon relapse. Using the previously described mouse model for SCLC, we found that th...
- Bone Marrow-Derived Myofibroblasts Contribute to the Mesenchymal Stem Cell Niche and Promote Tumor Growth
[作者：Quante, M; Tu, SP; Tomita, H; Gonda, T; Wang, SSW; Takashi, S; Baik, GH; Shibata, W; DiPrete, B; Betz, KS; Friedman, R; Varro, A; Tycko, B; Wang, TC,期刊：Cancer Cell, 页码：257-272 , 文章类型： Article，,卷期：2011年19-2]
- Carcinoma-associated fibroblasts (CAFs) that express alpha-smooth muscle actin (alpha SMA) contribute to cancer progression, but their precise origin and role are unclear. Using mouse models of inflammation-induced gastr...
- The MDM2 Promoter SNP285C/309G Haplotype Diminishes Sp1 Transcription Factor Binding and Reduces Risk for Breast and Ovarian Cancer in Caucasians
[作者：Knappskog, S; Bjornslett, M; Myklebust, LM; Huijts, PEA; Vreeswijk, MP; Edvardsen, H; Guo, YL; Zhang, XM; Yang, M; Ylisaukko-oja, SK; Alhopuro, P; Arola, J; Tollenaar, RAEM; van Asperen, CJ; Seynaeve, C; Staalesen, V; Chrisanthar, R; Lokkevik, E; Salvesen, HB; Evans, DG; Newman, WG; Lin, DX; Aaltonen, LA; Borresen-Dale, AL; Tell, GS; Stoltenberg, C; Romundstad, P; Hveem, K; Lillehaug, JR; Vatten, L; Devilee, P; Dorum, A; Lonning, PE,期刊：Cancer Cell, 页码：273-282 , 文章类型： Article，,卷期：2011年19-2]
- MDM2 plays a key role in modulating p53 function. The MDM2 SNP309T > G promoter polymorphism enhances Sp1 binding and has been linked to cancer risk and young age at diagnosis although with conflicting evidence. We repor...
- JAK2V617F-Mediated Phosphorylation of PRMT5 Downregulates Its Methyltransferase Activity and Promotes Myeloproliferation
[作者：Liu, F; Zhao, XY; Perna, F; Wang, L; Koppikar, P; Abdel-Wahab, O; Harr, MW; Levine, RL; Xu, H; Tefferi, A; Deblasio, A; Hatlen, M; Menendez, S; Nimer, SD,期刊：Cancer Cell, 页码：283-294 , 文章类型： Article，,卷期：2011年19-2]
- The JAK2V617F constitutively activated tyrosine kinase is found in most patients with myeloproliferative neoplasms. While examining the interaction between JAK2 and PRMT5, an arginine methyltransferase originally identif...
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