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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共7条记录   Steroid Resistance in Severe Asthma: Current Mechanisms and Future Treatment [作者：Durham, A; Adcock, IM; Tliba, O,期刊：Current Pharmaceutical Design, 页码：674-684 , 文章类型： Review，,卷期：2011年17-7] The disproportionate cost of treating asthmatic patients who do not respond to conventional anti-inflammatory therapies makes delineation of the mechanism for glucocorticoid resistance an important field of asthma resear... The Role of Mast Cells in the Structural Alterations of the Airways as a Potential Mechanism in the Pathogenesis of Severe Asthma [作者：Carter, RJF; Bradding, P,期刊：Current Pharmaceutical Design, 页码：685-698 , 文章类型： Review，,卷期：2011年17-7] Mast cells, traditionally regarded as effector cells of the immune system, have more recently been demonstrated to be key figures in initiating, developing and sustaining complex pathophysiological processes underlying a... Challenges for the Development of New Treatments for Severe Asthma: A Pharmaceutical Perspective [作者：Knowles, RG,期刊：Current Pharmaceutical Design, 页码：699-702 , 文章类型： Review，,卷期：2011年17-7] The pharmaceutical industry is interested in developing new treatments for severe asthma ( SA), recognising that there is a substantial unmet clinical need in this area. However, it faces a significant set of barriers in... Challenges in the Management of Severe Asthma: Role of Current and Future Therapies [作者：Oliveinstein, R; Al Jahdali, H; Alkhamis, N; Halwani, R; Al-Muhsen, S; Hamid, Q,期刊：Current Pharmaceutical Design, 页码：703-711 , 文章类型： Review，,卷期：2011年17-7] Severe asthma is a complex and heterogeneous phenotype characterized by persistent symptoms and poor control. While some patients respond to high doses of inhaled corticosteroids in combination with long-acting beta-agon... A Review of Molecular Modelling Studies of Dihydrofolate Reductase Inhibitors Against Opportunistic Microorganisms and Comprehensive Evaluation of New Models [作者：Tawari, NR; Bag, S; Degani, MS,期刊：Current Pharmaceutical Design, 页码：712-751 , 文章类型： Review，,卷期：2011年17-7] Dihydrofolate reductase (DHFR) has been used as a target for antimicrobial drug discovery against a variety of pathogenic microorganisms, including opportunistic microorganisms; Pneumocystis carinii (pc), Toxoplasma gond... Transcriptional Regulation of Inflammatory Genes Associated with Severe Asthma [作者：Clifford, RL; Coward, WR; Knox, AJ; John, AE,期刊：Current Pharmaceutical Design, 页码：653-666 , 文章类型： Review，,卷期：2011年17-7] The 10% of patients with the most severe asthma are responsible for a large part of healthcare expenditure and morbidity. Understanding the processes involved is key if new therapeutic approaches are to be developed. Evi... Immunopathogenesis of Severe Asthma [作者：Brightling, CE; Gupta, S; Hollins, F; Sutcliffe, A; Amrani, Y,期刊：Current Pharmaceutical Design, 页码：667-673 , 文章类型： Review，,卷期：2011年17-7] Severe asthma is a complex heterogeneous disease with substantial unmet clinical need. Understanding the immunopathogenesis is likely to provide insights into potential novel therapies. To date researchers have focussed ...