- Structural and Functional Characterization of gamma-Type Phospholipase A(2) Inhibitor from Bothrops jararacussu Snake Plasma
[作者:Oliveira, CZ; Santos, NA; Menaldo, DL; Boldrini-Franca, J; Giglio, JR; Calderon, LA; Stabeli, RG; Rodrigues, FHS; Tasic, L; da Silva, SL; Soares, AM,期刊:Current Topics in Medicinal Chemistry, 页码:2509-2519 , 文章类型: Review,,卷期:2011年11-20]
- Phospholipases A(2) (PLA(2)s) from snake venoms comprise a group of 14-18 kDa proteins, responsible for several toxic effects induced by the whole venom. Considering this, studies aiming at the search for natural inhibit...
- The Polyphenol 3, 4, 5-Tri-hydroxy Benzoic Acid Inhibits Indian Daboia russelli Venom and Its Hemorrhagic Complex Induced Local Toxicity
[作者:Mahadeswaraswamy, YH; Kumar, MS; Gowtham, YJ; Nagaraju, S; Girish, KS; Kemparaju, K,期刊:Current Topics in Medicinal Chemistry, 页码:2520-2530 , 文章类型: Review,,卷期:2011年11-20]
- Despite a long history on treatment and management of snakebite, as of now, no satisfactory cure exists to treat local toxicity, including anti-venom therapy. Several natural compounds from plants and their synthetic ana...
- Neutralization of Local Toxicity Induced by Vipera russelli Phospholipase A(2) by Lipophilic Derivative of Ascorbic Acid
[作者:Mohamed, R; Shivaprasad, HV; Jameel, NM; Shekar, MA; Vishwanath, BS,期刊:Current Topics in Medicinal Chemistry, 页码:2531-2539 , 文章类型: Review,,卷期:2011年11-20]
- L-ascorbic acid upon condensation with palmitic acid in the presence of sulphuric acid results in L-ascorbic acid-6-palmitate (AP). The effect of L-ascorbic acid derivative, AP on the pharmacological activities of purifi...
- Therapeutic Potential of Peptides with Neutralizing Ability Towards the Venom and Toxin (CaTx-I) of Crotalus adamanteus
[作者:Samy, RP; Thwin, MM; Stiles, BG; Bow, H; Chow, VTK; Gopalakrishnakone, P,期刊:Current Topics in Medicinal Chemistry, 页码:2540-2555 , 文章类型: Review,,卷期:2011年11-20]
- The CaTx-I (PLA(2)) toxin of Crotalus adamanteus venom is responsible for most of the symptoms observed during envenomation. Synthetic peptides were designed and screened for venom (0.8 mu g/ml) and CaTx-I (0.1 mu M) inh...
- Daboia russelli Venom Hyaluronidase: Purification, Characterization and Inhibition by beta-3-(3-Hydroxy-4-Oxopyridyl) alpha-Amino-Propionic Acid
[作者:Mahadeswaraswamy, YH; Manjula, B; Devaraja, S; Girish, KS; Kemparaju, K,期刊:Current Topics in Medicinal Chemistry, 页码:2556-2565 , 文章类型: Review,,卷期:2011年11-20]
- The present study describes the purification and characterization of a hyaluronidase (DRHyal-II) from Daboia/Vipera russelli venom and its inhibition by beta-3-(3-hydroxy-4-oxopyridyl) alpha-amino-propionic acid, the mim...
- Protective Effect of Schizolobium parahyba Flavonoids Against Snake Venoms and Isolated Toxins
[作者:Vale, LHF; Mendes, MM; Fernandes, RS; Costa, TR; Hage-Melim, LIS; Sousa, MA; Hamaguchi, A; Homsi-Brandeburgo, MI; Franca, SC; Silva, CHTP; Pereira, PS; Soares, AM; Rodrigues, VM,期刊:Current Topics in Medicinal Chemistry, 页码:2566-2577 , 文章类型: Review,,卷期:2011年11-20]
- Four compounds (isoquercitrin, myricetin-3-O-glucoside, catechin and gallocatechin) were isolated from lyophilized aqueous extract of Schizolobium parahyba leaves by chromatography on Sephadex LH-20, followed by semi-pre...
- Characterization of Major Zinc Containing Myonecrotic and Procoagulant Metalloprotease 'Malabarin' from Non Lethal Trimeresurus malabaricus Snake Venom with Thrombin Like Activity: Its Neutralization by Chelating Agents
[作者:Gowda, CDR; Shivaprasad, HV; Kumar, RV; Rajesh, R; Saikumari, YK; Frey, BM; Frey, FJ; Sharath, BK; Vishwanath, BS,期刊:Current Topics in Medicinal Chemistry, 页码:2578-2588 , 文章类型: Review,,卷期:2011年11-20]
- A major myonecrotic zinc containing metalloprotease 'malabarin' with thrombin like activity was purified by the combination of gel permeation and anion exchange chromatography from T. malabaricus snake venom. MALDI-TOF a...
- Inhibition of Hemorrhagic Activity of Viper Venoms by N-acetyl Cysteine: Involvement of N-acetyl and Thiol Groups
[作者:Sunitha, K; Hemshekhar, M; Santhosh, MS; Kumar, MS; Kemparaju, K; Girish, KS,期刊:Current Topics in Medicinal Chemistry, 页码:2589-2600 , 文章类型: Review,,卷期:2011年11-20]
- The mortality rate due to snakebite is reduced markedly by the use of anti-venoms, which are the only medically approved remedial agents available. The anti-venoms effectively neutralize the systemic toxicity but offer n...
|