- Uridine Function in the Central Nervous System
[作者:Dobolyi, A; Juhasz, G; Kovacs, Z; Kardos, J,期刊:Current Topics in Medicinal Chemistry, 页码:1058-1067 , 文章类型: Review,,卷期:2011年11-8]
- In the adult nervous system, the major source of nucleotide synthesis is the salvage pathway. Uridine is the major form of pyrimidine nucleosides taken up by the brain. Uridine is phosphorylated to nucleotides, which are...
- Metabolic Network of Nucleosides in the Brain
[作者:Ipata, PL; Camici, M; Micheli, V; Tozzi, MG,期刊:Current Topics in Medicinal Chemistry, 页码:909-922 , 文章类型: Review,,卷期:2011年11-8]
- Brain relies on circulating nucleosides, mainly synthesised de novo in the liver, for the synthesis of nucleotides, RNA, nuclear and mitochondrial DNA, coenzymes, and pyrimidine sugar-and lipid-conjugates. Essentially, t...
- Neurological Disorders of Purine and Pyrimidine Metabolism
[作者:Micheli, V; Camici, M; Tozzi, MG; Ipata, PL; Sestini, S; Bertelli, M; Pompucci, G,期刊:Current Topics in Medicinal Chemistry, 页码:923-947 , 文章类型: Review,,卷期:2011年11-8]
- Purines and pyrimidines, regarded for a long time only as building blocks for nucleic acid synthesis and intermediates in the transfer of metabolic energy, gained increasing attention since genetically determined aberrat...
- Molecular Biology of Nucleoside Transporters and their Distributions and Functions in the Brain
[作者:Parkinson, FE; Damaraju, VL; Graham, K; Yao, SYM; Baldwin, SA; Cass, CE; Young, JD,期刊:Current Topics in Medicinal Chemistry, 页码:948-972 , 文章类型: Review,,卷期:2011年11-8]
- Pyrimidine and purine nucleosides and their derivatives have critical functions and pharmacological applications in the brain. Nucleosides and nucleobases are precursors of nucleotides, which serve as the energy-rich cur...
- Area, Age and Gender Dependence of the Nucleoside System in the Brain: a Review of Current Literature
[作者:Kovacs, Z; Juhasz, G; Palkovits, M; Dobolyi, A; Kekesi, KA,期刊:Current Topics in Medicinal Chemistry, 页码:1012-1033 , 文章类型: Review,,卷期:2011年11-8]
- Nucleosides, such as uridine, inosine, guanosine and adenosine, may participate in the regulation of sleep, cognition, memory and nociception, the suppression of seizures, and have also been suggested to play a role in t...
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