- Progress in Hodgkin lymphoma: a population-based study on patients diagnosed in Sweden from 1973-2009
[作者:Sjoberg, J; Halthur, C; Kristinsson, SY; Landgren, O; Nygell, UA; Dickman, PW; Bjorkholm, M,期刊:Blood, 页码:990-996 , 文章类型: Article,,卷期:2012年119-4]
- In recent decades, attention has focused on reducing long-term, treatment-related morbidity and mortality in Hodgkin lymphoma (HL). In the present study, we looked for trends in relative survival for all patients diagnos...
- Trisomy 12 and elevated GLI1 and PTCH1 transcript levels are biomarkers for Hedgehog-inhibitor responsiveness in CLL
[作者:Decker, S; Zirlik, K; Djebatchie, L; Hartmann, D; Ihorst, G; Schmitt-Graeff, A; Herchenbach, D; Jumaa, H; Warmuth, M; Veelken, H; Dierks, C,期刊:Blood, 页码:997-1007 , 文章类型: Article,,卷期:2012年119-4]
- Hedgehog (HH) signaling is activated in various lymphoid malignancies, but conflicting results exist about its role in chronic lymphocytic leukemia (CLL). Here, we demonstrate that the expression of essential HH pathway ...
- Histone deacetylase inhibitors are potent inducers of gene expression in latent EBV and sensitize lymphoma cells to nucleoside antiviral agents
[作者:Ghosh, SK; Perrine, SP; Williams, RM; Faller, DV,期刊:Blood, 页码:1008-1017 , 文章类型: Article,,卷期:2012年119-4]
- Induction of EBV lytic-phase gene expression, combined with exposure to an antiherpes viral drug, represents a promising targeted therapeutic approach to EBV-associated lymphomas. Short-chain fatty acids or certain chemo...
- Global gene expression profiling in mouse plasma cell tumor precursor and bystander cells reveals potential intervention targets for plasma cell neoplasia
[作者:LeGrand, J; Park, ES; Wang, HY; Gupta, S; Owens, JD; Nelson, PJ; DuBois, W; Bair, T; Janz, S; Mushinski, JF,期刊:Blood, 页码:1018-1028 , 文章类型: Article,,卷期:2012年119-4]
- Tumor progression usually proceeds through several sequential stages, any of which could be targets for interrupting the progression process if one understood these steps at the molecular level. We extracted nascent plas...
- FGFR2 genotype and risk of radiation-associated breast cancer in Hodgkin lymphoma
[作者:Ma, YP; van Leeuwen, FE; Cooke, R; Broeks, A; Enciso-Mora, V; Olver, B; Lloyd, A; Broderick, P; Russell, NS; Janus, C; Ashworth, A; Houlston, RS; Swerdlow, AJ,期刊:Blood, 页码:1029-1031 , 文章类型: Article,,卷期:2012年119-4]
- Women treated at young ages with supradiaphragmatic radiotherapy for Hodgkin lymphoma (HL) have a highly increased risk of breast cancer. For personalized advice and follow-up regimens for patients, information is needed...
- Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras
[作者:Xu, J; Hedberg, C; Dekker, FJ; Li, Q; Haigis, KM; Hwang, E; Waldmann, H; Shannon, K,期刊:Blood, 页码:1032-1035 , 文章类型: Article,,卷期:2012年119-4]
- The palmitoylation/depalmitoylation cycle of posttranslational processing is a potential therapeutic target for selectively inhibiting the growth of hematologic cancers with somatic NRAS mutations. To investigate this qu...
- Enucleation of human erythroblasts involves non-muscle myosin IIB
[作者:Ubukawa, K; Guo, YM; Takahashi, M; Hirokawa, M; Michishita, Y; Nara, M; Tagawa, H; Takahashi, N; Komatsuda, A; Nunomura, W; Takakuwa, Y; Sawada, K,期刊:Blood, 页码:1036-1044 , 文章类型: Article,,卷期:2012年119-4]
- Mammalian erythroblasts undergo enucleation, a process thought to be similar to cytokinesis. Although an assemblage of actin, non-muscle myosin II, and several other proteins is crucial for proper cytokinesis, the role o...
- AUF-1 and YB-1 are critical determinants of beta-globin mRNA expression in erythroid cells
[作者:van Zalen, S; Jeschke, GR; Hexner, EO; Russell, JE,期刊:Blood, 页码:1045-1053 , 文章类型: Article,,卷期:2012年119-4]
- The normal accumulation of p-globin protein in terminally differentiating erythroid cells is critically dependent on the high stability of its encoding mRNA. The molecular basis for this property, though, is incompletely...
- Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis
[作者:Pleines, I; Hagedorn, I; Gupta, S; May, F; Chakarova, L; van Hengel, J; Offermanns, S; Krohne, G; Kleinschnitz, C; Brakebusch, C; Nieswandt, B,期刊:Blood, 页码:1054-1063 , 文章类型: Article,,卷期:2012年119-4]
- Vascular injury initiates rapid platelet activation that is critical for hemostasis, but it also may cause thrombotic diseases, such as myocardial infarction or ischemic stroke. Reorganizations of the platelet cytoskelet...
- Platelet TGF-beta 1 contributions to plasma TGF-beta 1, cardiac fibrosis, and systolic dysfunction in a mouse model of pressure overload
[作者:Meyer, A; Wang, W; Qu, JX; Croft, L; Degen, JL; Coller, BS; Ahamed, J,期刊:Blood, 页码:1064-1074 , 文章类型: Article,,卷期:2012年119-4]
- Circulating platelets contain high concentrations of TGF-beta 1 in their et-granules and release it on platelet adhesion/activation. We hypothesized that uncontrolled in vitro release of platelet TGF-beta 1 may confound ...
- IFN-gamma and indoleamine 2,3-dioxygenase signaling between donor dendritic cells and T cells regulates graft versus host and graft versus leukemia activity
[作者:Lu, Y; Giver, CR; Sharma, A; Li, JM; Darlak, KA; Owens, LM; Roback, JD; Galipeau, J; Waller, EK,期刊:Blood, 页码:1075-1085 , 文章类型: Article,,卷期:2012年119-4]
- Allogeneic hematopoietic stem cell transplantation (HSCT) can eradicate chemorefractory leukemia through the graft-versus-leukemia (GVL) activity of donor T cells. However, the clinical success of allo-HSCT is limited by...
- Presence of high-ERG expression is an independent unfavorable prognostic marker in MLL-rearranged childhood myeloid leukemia
[作者:Pigazzi, M; Masetti, R; Martinolli, F; Manara, E; Beghin, A; Rondelli, R; Locatelli, F; Fagioli, F; Pession, A; Basso, G,期刊:Blood, 页码:1086-1087 , 文章类型: Letter,,卷期:2012年119-4]
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- High ERG gene expression is an unfavorable prognostic marker in pediatric acute myeloid leukemia Response
[作者:Staffas, A; Kanduri, M; Hovland, R; Rosenquist, R; Ommen, HB; Abrahamsson, J; Forestier, E; Jahnukainen, K; Jonsson, OG; Zeller, B; Palle, J; Lonnerholm, G; Hasle, H; Ehrencrona, H; Palmqvist, L,期刊:Blood, 页码:1087-1088 , 文章类型: Letter,,卷期:2012年119-4]
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- Response: T cells are required for the CMV-induced antileukemia effect after transplant
[作者:Elmaagacli, AH; Koldehoff, M; Lindemann, M; Sonius, M; Ditschkowski, M; Steckel, N; Beelen, DW,期刊:Blood, 页码:1090-1091 , 文章类型: Letter,,卷期:2012年119-4]
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