- Nutrient isothiocyanates covalently modify and inhibit the inflammatory cytokine macrophage migration inhibitory factor (MIF)
[作者:Cross, JV; Rady, JM; Foss, FW; Lyons, CE; MacDonald, TL; Templeton, DJ,期刊:Biochemical Journal, 页码:315-321 , 文章类型: Article,,卷期:2009年423-Part 3]
- Dietary ITCs (isothiocyanates) prevent cancer and show other bioactivities in vivo. As electrophiles, ITCs may covalently modify cellular proteins. Using a novel proteomics screen, we identified MIF (macrophage migration...
- Evolution of vertebrate glucokinase regulatory protein from a bacterial N-acetylmuramate 6-phosphate etherase
[作者:Veiga-da-Cunha, M; Sokolova, T; Opperdoes, F; Van Schaftingen, E,期刊:Biochemical Journal, 页码:323-332 , 文章类型: Article,,卷期:2009年423-Part 3]
- Mammalian GKRP [GK (glucokinase) regulatory protein], a fructose 6-phosphate and fructose I-phosphate sensitive inhibitor of GK, appears to have resulted from the duplication of a gene similar to bacterial N-acetylmurama...
- Eukaryatic GCP1 is a conserved mitochondrial protein required for progression of embryo development beyond the globular stage in Arabidopsis thaliana
[作者:Haussuehl, K; Huesgen, PF; Meier, M; Dessi, P; Glaser, E; Adamski, J; Adamska, I,期刊:Biochemical Journal, 页码:333-341 , 文章类型: Article,,卷期:2009年423-Part 3]
- GCPs (glycoproteases) are members of the HSP70 (beat-shock protein 70)/actin ATPase superfamily that are highly conserved in taxonomically diverse species from bacteria to man, suggesting an essential physiological role....
- Fluorine substitutions in an antigenic peptide selectively modulate T-cell receptor binding in a minimally perturbing manner
[作者:Piepenbrink, KH; Borbulevych, OY; Sommese, RF; Clemens, J; Armstrong, KM; Desmond, C; Do, P; Baker, BM,期刊:Biochemical Journal, 页码:353-361 , 文章类型: Article,,卷期:2009年423-Part 3]
- TCR (T-cell receptor) recognition of antigenic peptides bound and presented by MHC (major histocompatibility complex) molecules forms the basis of the cellular immune response to pathogens and cancer. TCRs bind peptide-M...
- The NADPH oxidase Nox4 restricts the replicative lifespan of human endothelial cells
[作者:Lener, B; Koziel, R; Pircher, H; Hutter, E; Greussing, R; Herndler-Brandstetter, D; Hermann, M; Unterluggauer, H; Jansen-Durr, P,期刊:Biochemical Journal, 页码:363-374 , 文章类型: Article,,卷期:2009年423-Part 3]
- The free radical theory of aging proposes that ROS (reactive oxygen species) are major driving forces of aging, and are also critically involved in cellular senescence. Besides the mitochondrial respiratory chain, altern...
- MAC inhibitors suppress mitochondrial apoptosis
[作者:Peixoto, PM; Ryu, SY; Bombrun, A; Antonsson, B; Kinnally, KW,期刊:Biochemical Journal, 页码:381-387 , 文章类型: Article,,卷期:2009年423-Part 3]
- MAC (mitochondrial apoptosis-induced channel) forms in the mitochondrial outer membrane and unleashes cytochrorne c to orchestrate the execution of the cell. MAC opening is the commitment step of intrinsic apoptosis. Hen...
- Functional characterization of the interactions between endosomal adaptor protein APPL1 and the NuRD co-repressor complex
[作者:Banach-Orlowska, M; Pilecka, I; Torun, A; Pyrzynska, B; Miaczynska, M,期刊:Biochemical Journal, 页码:389-400 , 文章类型: Article,,卷期:2009年423-Part 3]
- Multifunctional adaptor protein APPL1 [adaptor protein containing PH (pleckstrin homology) domain, PTB (phosphotyrosine binding) domain and leucine zipper motif] belongs to a growing group of endocytic proteins which act...
- Effect of pyruvate, lactate and insulin on ATP supply and demand in unpaced perfused rat heart
[作者:Korzeniewski, B; Deschodt-Arsac, V; Calmettes, G; Gouspillou, G; Franconi, JM; Diolez, P,期刊:Biochemical Journal, 页码:421-428 , 文章类型: Article,,卷期:2009年423-Part 3]
- Mitochondrial respiration/oxidative phosphorylation is the main source of energy, in the form of ATP, in the heart under physiological conditions. Different respiratory substrates were used in various experiments during ...
- The crystal structure of caspase-6, a selective effector of axonal degeneration
[作者:Baumgartner, R; Meder, G; Briand, C; Decock, A; D'Arcy, A; Hassiepen, U; Morse, R; Renatus, M,期刊:Biochemical Journal, 页码:429-439 , 文章类型: Article,,卷期:2009年423-Part 3]
- Neurodegenerative diseases pose one of the most pressing unmet medical needs today. It has long been recognized that caspase-6 may play a role in several neurodegenerative diseases for which there are currently no diseas...
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