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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共28条记录   Simulations of the BM2 Proton Channel Transmembrane Domain from Influenza Virus B [作者：Rouse, SL; Carpenter, T; Stansfeld, PJ; Sansom, MSP,期刊：Biochemistry, 页码：9949-9951 , 文章类型： Article，,卷期：2009年48-42] BM2 is a small integral membrane protein from influenza B virus which forms proton-permeable channels. Coarse-grained (CG) molecular dynamics simulations have been used to produce a model of the BM2 channel by self-assem... Amino Acid Asp181 of 5 '-Flap Endonuclease 1 Is a Useful Target for Chemotherapeutic Development [作者：Panda, H; Jaiswal, AS; Corsino, PE; Armas, ML; Law, BK; Narayan, S,期刊：Biochemistry, 页码：9952-9958 , 文章类型： Article，,卷期：2009年48-42] DNA alkylation-induced damageis one of the most efficacious anticancer therapeutic strategies. Enhanced DNA alkylation and weakened DNA repair capacity in cancer cells are responsible for the effectiveness of DNA-alkylat... Translation Initiation from Two In-Frame AUGs Generates Mitochondrial and Cytoplasmic Forms of the p43 Component of the Multisynthetase Complex [作者：Shalak, V; Kaminska, M; Mirande, M,期刊：Biochemistry, 页码：9959-9968 , 文章类型： Article，,卷期：2009年48-42] In humans, nine aminoacyl-tRNA synthetases form a stable multiprotein complex with the three auxiliary proteins p18, p38, and p43. The N-terminal moiety of p43 is involved in its anchoring to the complex, and its C-termi... Spectroscopic Studies of the AppA BLUF Domain from Rhodobacter sphaeroides: Addressing Movement of Tryptophan 104 in the Signaling State [作者：Dragnea, V; Arunkumar, AI; Yuan, H; Giedroc, DP; Bauer, CE,期刊：Biochemistry, 页码：9969-9979 , 文章类型： Article，,卷期：2009年48-42] Previous crystallographic studies of the AppA BLUF domain indicated that Trp104 is capable of undertaking alternate conformations depending on the length of the BLUF domain, A BLUF domain containing a C-terminal deletion... Strong Hydrogen Bond between Glutamic Acid 46 and Chromophore Leads to the Intermediate Spectral Form and Excited State Proton Transfer in the Y42F Mutant of the Photoreceptor Photoactive Yellow Protein [作者：Joshi, CP; Otto, H; Hoersch, D; Meyer, TE; Cusanovich, MA; Heyn, MP,期刊：Biochemistry, 页码：9980-9993 , 文章类型： Article，,卷期：2009年48-42] In the Y42F mutant of photoactive yellow protein (PYP) the photoreceptor is in an equilibrium between two dark states, the yellow and intermediate spectral forms, absorbing at 457 and 390 nm, respectively. The nature of ... Chemical and Thermal Unfolding of Glypican-1: Protective Effect of Heparan Sulfate against Heat-Induced Irreversible Aggregation [作者：Svensson, G; Linse, S; Mani, K,期刊：Biochemistry, 页码：9994-10004 , 文章类型： Article，,卷期：2009年48-42] Glypicans are cell-surface heparan sulfate proteoglycans that influence Wnt, hedgehog, decapentaplegic, and fibroblast growth factor activity via their heparan sulfate chains. However, recent studies have shown that glyp... Insights into the Molecular Determinants of Proton Inhibition in an Acid-Inactivated Degenerins and Mammalian Epithelial Na+ Channel [作者：Wang, Y; Bianchi, L,期刊：Biochemistry, 页码：10005-10013 , 文章类型： Article，,卷期：2009年48-42] Mammalian ASIC channels of the DEG/ENaC superfamily are gated by extracellular protons and function to mediate touch and pain sensitivity, learning and memory, and fear conditioning. The recently solved crystal structure... Allosteric Control of Regulated Scaffolding in Membrane-Associated Guanylate Kinases [作者：Marcette, J; Hood, IV; Johnston, CA; Doe, CQ; Prehoda, KE,期刊：Biochemistry, 页码：10014-10019 , 文章类型： Article，,卷期：2009年48-42] Membrane-associated guanylate kinases (MAGUKs) organize protein complexes at specific cellular sites by regulating interactions with their COOH-terminal guanylate kinase-like domains (GKs). Negative regulation of MAGUK G... Exploring Molecular Mechanisms of Ligand Recognition by Opioid Receptors with Metadynamics [作者：Provasi, D; Bortolato, A; Filizola, M,期刊：Biochemistry, 页码：10020-10029 , 文章类型： Article，,卷期：2009年48-42] Opioid receptors are G protein-coupled receptors (GPCRs) of utmost significance in the development of potent analgesic drugs for the treatment of severe pain. An accurate evaluation at the molecular level of the ligand b... Structure-Based Stability Analysis of an Extremely Stable Dimeric DNA Binding Protein from Sulfolobus islandicus [作者：Weininger, U; Zeeb, M; Neumann, P; Low, C; Stubbs, MT; Lipps, G; Balbach, J,期刊：Biochemistry, 页码：10030-10037 , 文章类型： Article，,卷期：2009年48-42] ORF56 is a small and thermodynamically extremely stable dimeric protein from the archaeon Sulfolobus islandicus. This DNA binding protein is encoded on plasmid pRN1 and possibly controls the copy number of the plasmid. W... Intrinsic Dynamics in ECFP and Cerulean Control Fluorescence Quantum Yield [作者：Lelimousin, M; Noirclerc-Savoye, M; Lazareno-Saez, C; Paetzold, B; Le Vot, S; Chazal, R; Macheboeuf, P; Field, MJ; Bourgeois, D; Royant, A,期刊：Biochemistry, 页码：10038-10046 , 文章类型： Article，,卷期：2009年48-42] Enhanced cyan fluorescent protein (ECPP) and its variant Cerulean are genetically encoded fluorophores widely used as donors in FRET-based cell imaging experiments. First, we have confirmed through denaturation experimen... Conformational Changes Specific for Pseudophosphorylation at Serine 262 Selectively Impair Binding of Tau to Microtubules [作者：Fischer, D; Mukrasch, MD; Biernat, J; Bibow, S; Blackledge, M; Griesinger, C; Mandelkow, E; Zweckstetter, M,期刊：Biochemistry, 页码：10047-10055 , 文章类型： Article，,卷期：2009年48-42] Aggregation of the micro tubule-associated protein tau into neurofibrillary tangles is the pathological hallmark of a variety of dementias. For reasons not yet known, tau becomes excessively phosphorylated in Alzheimer's... Interaction between Cardiotonic Steroids and Na,K-ATPase. Effects of pH and Ouabain-Induced Changes in Enzyme Conformation [作者：Cornelius, F; Mahmmoud, YA,期刊：Biochemistry, 页码：10056-10065 , 文章类型： Article，,卷期：2009年48-42] The Na,K-ATPase belongs to the P-type ATPase family of primary active cation pumps. It maintains the transmembrane gradients of Na+ and K+ across the cell membrane essential for cell homeostasis. The Na,K-ATPase is speci... [H-3]Chlorpromazine Photolabeling of the Torpedo Nicotinic Acetylcholine Receptor Identifies Two State-Dependent Binding Sites in the Ion Channel [作者：Chiara, DC; Hamouda, AK; Ziebell, MR; Mejia, LA; Garcia, G; Cohen, JB,期刊：Biochemistry, 页码：10066-10077 , 文章类型： Article，,卷期：2009年48-42] Chlor-promazine (CPZ), a potent nicotinic acetylcholine receptor (nAChR) noncompetitive antagonist, binds with higher affinity in the ion channel in the desensitized state than in the closed channel state and with low af... Cystic Fibrosis Transmembrane Conductance Regulator: Using Differential Reactivity toward Channel-Permeant and Channel-Impermeant Thiol-Reactive Probes To Test a Molecular Model for the Pore [作者：Alexander, C; Ivetac, A; Liu, XH; Norimatsu, Y; Serrano, JR; Landstrom, A; Sansom, M; Dawson, DC,期刊：Biochemistry, 页码：10078-10088 , 文章类型： Article，,卷期：2009年48-42] The sixth transmembrane segment (TM6) of the CFTR chloride channel has been intensively investigated. The effects of amino acid substitutions and chemical modification of engineered cysteines (cysteine scanning) on chann... Oligosaccharide Binding in Escherichia coli Glycogen Synthase [作者：Sheng, F; Yep, A; Feng, L; Preiss, J; Geiger, JH,期刊：Biochemistry, 页码：10089-10097 , 文章类型： Article，,卷期：2009年48-42] Glycogen/starch synthase elongates glucan chains and is the key enzyme in the synthesis of glycogen in bacteria and starch in plants. Cocrystallization of Escherichia coli wild-type glycogen synthase (GS) with substrate ...