- C-11-verapamil to Assess P-gp Function in Human Brain During Aging, Depression and Neurodegenerative Disease
[作者:Bartels, AL; de Klerk, OL; Kortekaas, R; de Vries, JJ; Leenders, KL,期刊:Current Topics in Medicinal Chemistry, 页码:1775-1784 , 文章类型: Review,,卷期:2010年10-17]
- P-glycoprotein (P-gp) at the blood-brain barrier (BBB) functions as an active efflux pump by extruding a wide range of substrates from the brain. This is important for maintaining loco-regional homeostasis and for protec...
- Carbon-11 Labeled Tracers for In Vivo Imaging of P-Glycoprotein Function: Kinetics, Advantages and Disadvantages
[作者:Luurtsema, G; Verbeek, J; Lubberink, M; Lammertsma, AA; Dierckx, R; Elsinga, P; Windhorst, AD; van Waarde, A,期刊:Current Topics in Medicinal Chemistry, 页码:1820-1833 , 文章类型: Review,,卷期:2010年10-17]
- P-glycoprotein (P-gp) is a drug efflux transporter with broad substrate specificity localized in the blood-brain barrier and in several peripheral organs. In order to understand the role of P-gp in physiological and path...
- Reversal of Multidrug Resistance by Natural Substances from Plants
[作者:Molnar, J; Engi, H; Hohmann, J; Molnar, P; Deli, J; Wesolowska, O; Michalak, K; Wang, Q,期刊:Current Topics in Medicinal Chemistry, 页码:1757-1768 , 文章类型: Review,,卷期:2010年10-17]
- The multidrug resistance (MDR) proteins that belong to the ATP-binding cassette superfamily such as P-glycoprotein (P-gp) and MRP1, are present in a majority of human tumors and constitute an important cause of therapeut...
- Substrates, Inhibitors and Activators of P-glycoprotein: Candidates for Radiolabeling and Imaging Perspectives
[作者:Colabufo, NA; Berardi, F; Perrone, MG; Capparelli, E; Cantore, M; Inglese, C; Perrone, R,期刊:Current Topics in Medicinal Chemistry, 页码:1703-1714 , 文章类型: Review,,卷期:2010年10-17]
- In recent years, several PET tracers for monitoring the activity and expression of P-gp at the BBB have been tested. P-gp substrates such as [C-11]verapamil and [C-11]loperamide can be employed to visualize P-gp activity...
- Using Structural and Mechanistic Information to Design Novel Inhibitors/Substrates of P-Glycoprotein
[作者:Klepsch, F; Stockner, T; Erker, T; Muller, M; Chiba, P; Ecker, GF,期刊:Current Topics in Medicinal Chemistry, 页码:1769-1774 , 文章类型: Review,,卷期:2010年10-17]
- Design of inhibitors of P-glycoprotein still represents a challenging task for medicinal chemists. The polyspecificity of the transporter combined with the limited structural information renders rational drug design appr...
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