- Development of Nitrile-Based Peptidic Inhibitors of Cysteine Cathepsins
[作者:Frizler, M; Stirnberg, M; Sisay, MT; Gutschow, M,期刊:Current Topics in Medicinal Chemistry, 页码:294-322 , 文章类型: Review,,卷期:2010年10-3]
- It is now becoming clear that several papain-like cysteine cathepsins are involved in the pathophysiology of diseases such as osteoporosis, autoimmune disorders, and cancer. Therefore, the development of potent and selec...
- Enzyme Kinetics and Hit Validation in Fluorimetric Protease Assays
[作者:Ludewig, S; Kossner, M; Schiller, M; Baumann, K; Schirmeister, T,期刊:Current Topics in Medicinal Chemistry, 页码:368-382 , 文章类型: Review,,卷期:2010年10-3]
- Fluorimetric assays are convenient and efficient to determine the inhibitory potency of enzyme inhibitors. Since enzyme activity can be blocked in a number of ways, it is important to determine the exact mode of inhibiti...
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