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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共7条记录   Chemokine Receptors as Targets in Medicinal Chemistry and Drug Discovery [作者：Merritt, JR; Webb, M,期刊：Current Topics in Medicinal Chemistry, 页码：1249-1249 , 文章类型： Editorial Material，,卷期：2010年10-13] CC Chemokine Receptor Small Molecule Antagonists in the Treatment of Rheumatoid Arthritis and Other Diseases: A Current View [作者：Liu, JQ; Merritt, JR,期刊：Current Topics in Medicinal Chemistry, 页码：1250-1267 , 文章类型： Review，,卷期：2010年10-13] CC chemokines and their receptors play a key role in mediating both physiological and pathological processes. Chemokine receptors have been widely recognized as attractive drug targets by the pharmaceutical industry. A n... CCR1 Antagonists: What Have We Learned From Clinical Trials [作者：Gladue, RP; Brown, MF; Zwillich, SH,期刊：Current Topics in Medicinal Chemistry, 页码：1268-1277 , 文章类型： Review，,卷期：2010年10-13] The identification of chemokines and their receptors as potent mediators of leukocyte infiltration raised interest in the potential role of these proteins on disease pathogenesis. This is exemplified by the chemokine rec... CCR2 Antagonists [作者：Struthers, M; Pasternak, A,期刊：Current Topics in Medicinal Chemistry, 页码：1278-1298 , 文章类型： Review，,卷期：2010年10-13] Inhibition of CCR2 has been considered as a target for multiple therapeutic diseases including autoimmune disease, atherosclerosis, pain, and metabolic disease, based in part on the critical role this receptor plays on m... Small Molecule Antagonists of the Chemokine Receptor CCR5 [作者：Lemoine, RC; Wanner, J,期刊：Current Topics in Medicinal Chemistry, 页码：1299-1338 , 文章类型： Review，,卷期：2010年10-13] This review will focus on the discovery and clinical development of small molecule antagonists of CCR5 for the treatment of HIV-1/AIDS, as well as for the potential treatment of inflammatory diseases. In particular, we w... Discovery of 3,4-Diaminocyclobut-3-ene-1,2-dione-Based CXCR2 Receptor Antagonists for the Treatment of Inflammatory Disorders [作者：Dwyer, MP; Biju, P,期刊：Current Topics in Medicinal Chemistry, 页码：1339-1350 , 文章类型： Review，,卷期：2010年10-13] The CXC chemokine receptor 2 (CXCR2) has attracted a considerable amount of attention as a target for therapeutic intervention due the key role this receptor plays in a number of inflammatory disorders. Over the past dec... Small Molecule Antagonists of Chemokine Receptors - is Promiscuity a Virtue? [作者：Pease, JE; Horuk, R,期刊：Current Topics in Medicinal Chemistry, 页码：1351-1358 , 文章类型： Review，,卷期：2010年10-13] A major function of the chemokine system is to coordinate the recruitment of leukocytes to specific locations within the tissues. The involvement of chemokine receptors in a multitude of inflammatory diseases, coupled wi...