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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共7条记录   Untitled [作者：Oyelere, AK,期刊：Current Topics in Medicinal Chemistry, 页码：1359-U121 , 文章类型： Editorial Material，,卷期：2010年10-14] Chemoinformatic Analysis of Biologically Active Macrocycles [作者：Brandt, W; Haupt, VJ; Wessjohann, LA,期刊：Current Topics in Medicinal Chemistry, 页码：1361-1379 , 文章类型： Review，,卷期：2010年10-14] In this review, macrocycles are defined as organic molecules containing at least one non-bridged cycle of 12 or more covalently connected atoms. Common statistical aspects as well as structure activity relationships (SAR... Macrocyclic Inhibitors of Hsp90 [作者：Johnson, VA; Singh, EK; Nazarova, LA; Alexander, LD; McAlpine, SR,期刊：Current Topics in Medicinal Chemistry, 页码：1380-1402 , 文章类型： Review，,卷期：2010年10-14] Heat shock proteins (HSP) are a family of highly conserved proteins, whose expression increases in response to stresses that may threaten cell survival. Over the past decade, heat shock protein 90 (Hsp90) has emerged as ... Advances in the Development of Macrocyclic Inhibitors of Hepatitis C Virus NS3-4A Protease [作者：Avolio, S; Summa, V,期刊：Current Topics in Medicinal Chemistry, 页码：1403-1422 , 文章类型： Review，,卷期：2010年10-14] Hepatitis C virus (HCV) is a major cause of acute hepatitis and chronic liver disease, including cirrhosis and hepatocellular carcinoma (HCC). No vaccine is currently available to prevent hepatitis C, and the current sta... Macrocyclic Histone Deacetylase Inhibitors [作者：Mwakwari, SC; Patil, V; Guerrant, W; Oyelere, AK,期刊：Current Topics in Medicinal Chemistry, 页码：1423-1440 , 文章类型： Review，,卷期：2010年10-14] Histone deacetylase inhibitors (HDACi) are an emerging class of novel anti-cancer drugs that cause growth arrest, differentiation, and apoptosis of tumor cells. In addition, they have shown promise as anti-parasitic, ant... Recent Advances in the Medicinal Chemistry of Novel Erythromycin-Derivatized Antibiotics [作者：Ying, L; Tang, DT,期刊：Current Topics in Medicinal Chemistry, 页码：1441-1469 , 文章类型： Review，,卷期：2010年10-14] Development of novel erythromycin-based antibiotics has been one of the most studied topics in the past three decades. Such tremendous efforts have generated a number of beneficiary drugs such as clarithromycin, azithrom... Macrocycle Molecules for the Management of Systemic Infections: the Clarithromycin Paradigm [作者：Giamarellos-Bourboulis, EJ,期刊：Current Topics in Medicinal Chemistry, 页码：1470-1475 , 文章类型： Review，,卷期：2010年10-14] Macrolides currently play a major role in the management of severe infections. Evidence derived from several retrospective studies have shown a significant reduction of mortality from community-acquired pneumonia upon tr...