个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共34条记录   Safety and efficacy of bortezomib-melphalan-prednisone-thalidomide followed by bortezomib-thalidomide maintenance (VMPT-VT) versus bortezomib-melphalan-prednisone (VMP) in untreated multiple myeloma patients with renal impairment [作者：Morabito, F; Gentile, M; Mazzone, C; Rossi, D; Di Raimondo, F; Bringhen, S; Ria, R; Offidani, M; Patriarca, F; Nozzoli, C; Petrucci, MT; Benevolo, G; Vincelli, I; Guglielmelli, T; Grasso, M; Marasca, R; Baldini, L; Montefusco, V; Musto, P; Cascavilla, N; Majolino, I; Musolino, C; Cavo, M; Boccadoro, M; Palumbo, A,期刊：Blood, 页码：5759-5766 , 文章类型： Article，,卷期：2011年118-22] We assessed efficacy, safety, and reversal of renal impairment (RI) in untreated patients with multiple myeloma given bortezomib-melphalan-prednisone-thalidomide followed by bortezomib-thalidomide (VMPT-VT) maintenance o... Pivotal trial with plant cell-expressed recombinant glucocerebrosidase, taliglucerase alfa, a novel enzyme replacement therapy for Gaucher disease [作者：Zimran, A; Brill-Almon, E; Chertkoff, R; Petakov, M; Blanco-Favela, F; Munoz, ET; Solorio-Meza, SE; Amato, D; Duran, G; Giona, F; Heitner, R; Rosenbaum, H; Giraldo, P; Mehta, A; Park, G; Phillips, M; Elstein, D; Altarescu, G; Szleifer, M; Hashmueli, S; Aviezer, D,期刊：Blood, 页码：5767-5773 , 文章类型： Article，,卷期：2011年118-22] Taliglucerase alfa (Protalix Biotherapeutics, Carmiel, Israel) is a novel plant cell-derived recombinant human beta-glucocerebrosidase for Gaucher disease. A phase 3, double-blind, randomized, parallelgroup, comparison-d... Anti-Escherichia coli asparaginase antibody levels determine the activity of second-line treatment with pegylated E coli asparaginase: a retrospective analysis within the ALL-BFM trials [作者：Willer, A; Gerss, J; Konig, T; Franke, D; Kuhnel, HJ; Henze, G; von Stackelberg, A; Moricke, A; Schrappe, M; Boos, J; Lanvers-Kaminsky, C,期刊：Blood, 页码：5774-5782 , 文章类型： Article，,卷期：2011年118-22] Hypersensitivity reactions limit the use of the antileukemic enzyme asparaginase (ASE). We evaluated Ab levels against Escherichia coli ASE and ASE activity in 1221 serum samples from 329 patients with acute lymphoblasti... Familial hemophagocytic lymphohistiocytosis type 3 (FHL3) caused by deep intronic mutation and inversion in UNC13D [作者：Meeths, M; Chiang, SCC; Wood, SM; Entesarian, M; Schlums, H; Bang, B; Nordenskjold, E; Bjorklund, C; Jakovljevic, G; Jazbec, J; Hasle, H; Holmqvist, BM; Rajic, L; Pfeifer, S; Rosthoj, S; Sabel, M; Salmi, TT; Stokland, T; Winiarski, J; Ljunggren, HG; Fadeel, B; Nordenskjold, M; Henter, JI; Bryceson, YT,期刊：Blood, 页码：5783-5793 , 文章类型： Article，,卷期：2011年118-22] Familial hemophagocytic lymphohistiocytosis (FHL) is an autosomal recessive, often-fatal hyperinflammatory disorder. Mutations in PRF1, UNC13D, STX11, and STXBP2 are causative of FHL2, 3, 4, and 5, respectively. In a maj... Hypomorphic mutations in PRF1, MUNC13-4, and STXBP2 are associated with adult-onset familial HLH [作者：Zhang, KJ; Jordan, MB; Marsh, RA; Johnson, JA; Kissell, D; Meller, J; Villanueva, J; Risma, KA; Wei, Q; Klein, PS; Filipovich, AH,期刊：Blood, 页码：5794-5798 , 文章类型： Article，,卷期：2011年118-22] Familial hemophagocytic lymphohistiocytosis (HLH) is a rare primary immunodeficiency disorder characterized by defects in cell-mediated cytotoxicity that results in fever, hepatosplenomegaly, and cytopenias. Familial HLH... Alemtuzumab therapy in T-cell prolymphocytic leukemia: comparing efficacy in a series treated intravenously and a study piloting the subcutaneous route [作者：Dearden, CE; Khot, A; Else, M; Hamblin, M; Grand, E; Roy, A; Hewamana, S; Matutes, E; Catovsky, D,期刊：Blood, 页码：5799-5802 , 文章类型： Article，,卷期：2011年118-22] Intravenous alemtuzumab is an effective and well-tolerated treatment for T-cell prolymphocytic leukemia (T-PLL). Alemtuzumab given intravenously as first-line treatment in 32 patients resulted in an overall response rate... SIV infection of rhesus macaques results in dysfunctional T- and B-cell responses to neo and recall Leishmania major vaccination [作者：Klatt, NR; Vinton, CL; Lynch, RM; Canary, LA; Ho, J; Darrah, PA; Estes, JD; Seder, RA; Moir, SL; Brenchley, JM,期刊：Blood, 页码：5803-5812 , 文章类型： Article，,卷期：2011年118-22] HIV infection is characterized by immune system dysregulation, including depletion of CD4(+) T cells, immune activation, and abnormal B-and T-cell responses. However, the immunologic mechanisms underlying lymphocytic dys... IL-36R ligands are potent regulators of dendritic and T cells [作者：Vigne, S; Palmer, G; Lamacchia, C; Martin, P; Talabot-Ayer, D; Rodriguez, E; Ronchi, F; Sallusto, F; Dinh, H; Sims, JE; Gabay, C,期刊：Blood, 页码：5813-5823 , 文章类型： Article，,卷期：2011年118-22] IL-36 alpha (IL-1F6), IL-36 beta (IL-1F8), and IL-36 gamma (IL-1F9) are members of the IL-1 family of cytokines. These cytokines bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1, w... Factor VIII alters tubular organization and functional properties of von Willebrand factor stored in Weibel-Palade bodies [作者：Bouwens, EAM; Mourik, MJ; van den Biggelaar, M; Eikenboom, JCJ; Voorberg, J; Valentijn, KM; Mertens, K,期刊：Blood, 页码：5947-5956 , 文章类型： Article，,卷期：2011年118-22] In endothelial cells, von Willebrand factor (VWF) multimers are packaged into tubules that direct biogenesis of elongated Weibel-Palade bodies (WPBs). WPB release results in unfurling of VWF tubules and assembly into str... Donor-specific anti-HLAAbs and graft failure in matched unrelated donor hematopoietic stem cell transplantation [作者：Ciurea, SO; Thall, PF; Wang, XM; Wang, SA; Hu, Y; Cano, P; Aung, F; Rondon, G; Molldrem, JJ; Korbling, M; Shpall, EJ; de Lima, M; Champlin, RE; Fernandez-Vina, M,期刊：Blood, 页码：5957-5964 , 文章类型： Article，,卷期：2011年118-22] Anti-HLA donor-specific Abs (DSAs) have been reported to be associated with graft failure in mismatched hematopoietic stem cell transplantation; however, their role in the development of graft failure in matched unrelate... HIV envelope-mediated, CCR5/alpha 4 beta 7-dependent killing of CD4-negative gamma delta T cells which are lost during progression to AIDS [作者：Li, HS; Pauza, CD,期刊：Blood, 页码：5824-5831 , 文章类型： Article，,卷期：2011年118-22] HIV infects and replicates in CD4+ T cells but effects on host immunity and disease also involve depletion, hyper-activation, and modification of CD4-negative cell populations. In particular, the depletion of CD4-negativ... TACI deficiency impairs sustained Blimp-1 expression in B cells decreasing long-lived plasma cells in the bone marrow [作者：Tsuji, S; Cortesao, C; Bram, RJ; Platt, JL; Cascalho, M,期刊：Blood, 页码：5832-5839 , 文章类型： Article，,卷期：2011年118-22] Deficiencies in transmembrane activator and CAML interactor (TACI) result in common variable immune deficiency, a syndrome marked by recurrent infections with encapsulated microorganisms, impaired production of antibodie... Soluble HLA-G dampens CD94/NKG2A expression and function and differentially modulates chemotaxis and cytokine and chemokine secretion in CD56(bright) and CD56(dim) NK cells [作者：Morandi, F; Ferretti, E; Castriconi, R; Dondero, A; Petretto, A; Bottino, C; Pistoia, V,期刊：Blood, 页码：5840-5850 , 文章类型： Article，,卷期：2011年118-22] Soluble HLA-G (sHLA-G) inhibits natural killer (NK) cell functions. Here, we investigated sHLA-G-mediated modulation of (1) chemokine receptor and NK receptor expression and function and (2) cytokine and chemokine secret... LFA-1 blockade induces effector and regulatory T-cell enrichment in lymph nodes and synergizes with CTLA-4Ig to inhibit effector function [作者：Reisman, NM; Floyd, TL; Wagener, ME; Kirk, AD; Larsen, CP; Ford, ML,期刊：Blood, 页码：5851-5861 , 文章类型： Article，,卷期：2011年118-22] Despite encouraging results using lymphocyte function antigen-1 (LFA-1) blockade to inhibit BM and solid organ transplantation rejection in nonhuman primates and humans, the precise mechanisms underlying its therapeutic ... Phosphorylation of the myosin IIA tailpiece regulates single myosin IIA molecule association with lytic granules to promote NK-cell cytotoxicity [作者：Sanborn, KB; Mace, EM; Rak, GD; Difeo, A; Martignetti, JA; Pecci, A; Bussel, JB; Favier, R; Orange, JS,期刊：Blood, 页码：5862-5871 , 文章类型： Article，,卷期：2011年118-22] Natural killer (NK) cells are innate immune lymphocytes that provide critical defense against virally infected and transformed cells. NK-cell cytotoxicity requires the formation of an F-actin rich immunologic synapse (IS... Host-derived adiponectin is tumor-suppressive and a novel therapeutic target for multiple myeloma and the associated bone disease [作者：Fowler, JA; Lwin, ST; Drake, MT; Edwards, JR; Kyle, RA; Mundy, GR; Edwards, CM,期刊：Blood, 页码：5872-5882 , 文章类型： Article，,卷期：2011年118-22] The contributions of the host microenvironment to the pathogenesis of multiple myeloma, including progression from the non-malignant disorder monoclonal gammopathy of undetermined significance, are poorly understood. In ...