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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共29条记录   Cytoskeletal stabilization of inhibitory interactions in immunologic synapses of mature human dendritic cells with natural killer cells [作者：da Silva, RB; Graf, C; Munz, C,期刊：Blood, 页码：6487-6498 , 文章类型： Article，,卷期：2011年118-25] Human mature dendritic cells (DCs) can efficiently stimulate natural killer (NK)-cell responses without being targeted by their cytotoxicity. To understand this important regulatory crosstalk, we characterized the develo... The tolerogenic interplay(s) among HLA-G, myeloid APCs, and regulatory cells [作者：Carosella, ED; Gregori, S; LeMaoult, J,期刊：Blood, 页码：6499-6505 , 文章类型： Review，,卷期：2011年118-25] Myeloid antigen-presenting cells (APCs), regulatory cells, and the HLA-G molecule are involved in modulating immune responses and promoting tolerance. APCs are known to induce regulatory cells and to express HLA-G as wel... Notch signaling in acute lymphoblastic leukemia: any role for stromal microenvironment? [作者：Kamdje, AHN; Krampera, M,期刊：Blood, 页码：6506-6514 , 文章类型： Review，,卷期：2011年118-25] Notch signaling pathway regulates many different events of embryonic and adult development; among them, Notch plays an essential role in the onset of hematopoietic stem cells and influences multiple maturation steps of d... Chronic myeloproliferative neoplasms and subsequent cancer risk: a Danish population-based cohort study [作者：Frederiksen, H; Farkas, DK; Christiansen, CF; Hasselbalch, HC; Sorensen, HT,期刊：Blood, 页码：6515-6520 , 文章类型： Article，,卷期：2011年118-25] Patients with chronic myeloproliferative neoplasms, including essential thrombocythemia (ET), polycythemia vera (PV), and chronic myeloid leukemia (CML), are at increased risk of new hematologic malignancies, but their r... Dasatinib as first-line treatment for adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia [作者：Foa, R; Vitale, A; Vignetti, M; Meloni, G; Guarini, A; De Propris, MS; Elia, L; Paoloni, F; Fazi, P; Cimino, G; Nobile, F; Ferrara, F; Castagnola, C; Sica, S; Leoni, P; Zuffa, E; Fozza, C; Luppi, M; Candoni, A; Iacobucci, I; Soverini, S; Mandelli, F; Martinelli, G; Baccarani, M,期刊：Blood, 页码：6521-6528 , 文章类型： Article，,卷期：2011年118-25] Dasatinib is a potent BCR-ABL inhibitor effective in chronic myeloid leukemia and Ph(+) acute lymphoblastic leukemia (ALL) resistant/intolerant to imatinib. In the GIMEMA LAL1205 protocol, patients with newly diagnosed P... Bone microstructural changes revealed by high-resolution peripheral quantitative computed tomography imaging and elevated DKK1 and MIP-1 alpha levels in patients with MGUS [作者：Ng, AC; Khosla, S; Charatcharoenwitthaya, N; Kumar, SK; Achenbach, SJ; Holets, MF; McCready, LK; Melton, LJ; Kyle, RA; Rajkumar, SV; Drake, MT,期刊：Blood, 页码：6529-6534 , 文章类型： Article，,卷期：2011年118-25] Recent population-based studies demonstrate an increased fracture risk with monoclonal gammopathy of undetermined significance (MGUS). The etiology of this increased risk remains unclear, however, because areal bone mine... Oral arsenic trioxide-based maintenance regimens for first complete remission of acute promyelocytic leukemia: a 10-year follow-up study [作者：Au, WY; Kumana, CR; Lee, HKK; Lin, SY; Liu, H; Yeung, DYM; Lau, JSM; Kwong, YL,期刊：Blood, 页码：6535-6543 , 文章类型： Article，,卷期：2011年118-25] Seventy-six patients with acute promyelocytic leukemia (APL) in first complete remission after induction and consolidation by daunorubicin and cytosine arabinoside received oral arsenic trioxide (As(2)O(3))-based mainten... The ability of MLLto bind RUNX1 and methylate H3K4 at PU. 1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations [作者：Huang, G; Zhao, XH; Wang, L; Elf, S; Xu, H; Zhao, XY; Sashida, G; Zhang, Y; Liu, Y; Lee, J; Menendez, S; Yang, YY; Yan, XM; Zhang, P; Tenen, DG; Osato, M; Hsieh, JJD; Nimer, SD,期刊：Blood, 页码：6544-6552 , 文章类型： Article，,卷期：2011年118-25] The mixed-lineage leukemia (MLL) H3K4 methyltransferase protein, and the heterodimeric RUNX1/CBF beta transcription factor complex, are critical for definitive and adult hematopoiesis, and both are frequently targeted in... Dependency on the polycomb gene Ezh2 distinguishes fetal from adult hematopoietic stem cells [作者：Mochizuki-Kashio, M; Mishima, Y; Miyagi, S; Negishi, M; Saraya, A; Konuma, T; Shinga, J; Koseki, H; Iwama, A,期刊：Blood, 页码：6553-6561 , 文章类型： Article，,卷期：2011年118-25] Polycomb-group (PcG) proteins are essential regulators of hematopoietic stem cells (HSCs). In contrast to Bmi1, a component of Polycomb repressive complex 1 (PRC1), the role of PRC2 and its components in hematopoiesis re... Regulation of murine hematopoietic stem cell quiescence by Dmtf1 [作者：Kobayashi, M; Srour, EF,期刊：Blood, 页码：6562-6571 , 文章类型： Article，,卷期：2011年118-25] The cell-cycle status of hematopoietic stem cells (HSCs) is tightly regulated, most likely to balance maintenance of stem-cell status through quiescence and expansion/differentiation of the hematopoietic system. Tumor-su... The redox-sensitive transcription factor Nrf2 regulates murine hematopoietic stem cell survival independently of ROS levels [作者：Merchant, AA; Singh, A; Matsui, W; Biswal, S,期刊：Blood, 页码：6572-6579 , 文章类型： Article，,卷期：2011年118-25] Several studies have found that high levels of reactive oxidative species (ROS) are associated with stem cell dysfunction. In the present study, we investigated the role of nuclear factor erythroid-2related factor 2 (Nrf... Significant mobilization of both conventional and regulatory T cells with AMD3100 [作者：Kean, LS; Sen, S; Onabajo, O; Singh, K; Robertson, J; Stempora, L; Bonifacino, AC; Metzger, ME; Promislow, DEL; Mattapallil, JJ; Donahue, RE,期刊：Blood, 页码：6580-6590 , 文章类型： Article，,卷期：2011年118-25] In this study, we used the rhesus macaque model to determine the impact that AMD3100 has on lymphocyte mobilization, both alone and in combination with G-CSF. Our results indicate that, unlike G-CSF, AMD3100 substantiall... Evidence for the divergence of innate and adaptive T-cell precursors before commitment to the alpha beta and gamma delta lineages [作者：Kisielow, J; Tortola, L; Weber, J; Karjalainen, K; Kopf, M,期刊：Blood, 页码：6591-6600 , 文章类型： Article，,卷期：2011年118-25] In addition to adaptive T cells, the thymus supports the development of unconventional T cells such as natural killer T (NKT) and CD8 alpha alpha intraepithelial lymphocytes (IELs), which have innate functional propertie... Frequent loss of HLA alleles associated with copy number-neutral 6pLOH in acquired aplastic anemia [作者：Katagiri, T; Sato-Otsubo, A; Kashiwase, K; Morishima, S; Sato, Y; Mori, Y; Kato, M; Sanada, M; Morishima, Y; Hosokawa, K; Sasaki, Y; Ohtake, S; Ogawa, S; Nakao, S,期刊：Blood, 页码：6601-6609 , 文章类型： Article，,卷期：2011年118-25] Idiopathic aplastic anemia (AA) is a common cause of acquired BM failure. Although autoimmunity to hematopoietic progenitors is thought to be responsible for its pathogenesis, little is known about the molecular basis of... Doxycycline reduces fibril formation in a transgenic mouse model of AL amyloidosis [作者：Ward, JE; Ren, RY; Toraldo, G; SooHoo, P; Guan, J; O'Hara, C; Jasuja, R; Trinkaus-Randall, V; Liao, RL; Connors, LH; Seldin, DC,期刊：Blood, 页码：6610-6617 , 文章类型： Article，,卷期：2011年118-25] Systemic AL amyloidosis results from the aggregation of an amyloidogenic immunoglobulin (Ig) light chain (LC) usually produced by a plasma cell clone in the bone marrow. AL is the most rapidly fatal of the systemic amylo... General population low-count CLL-like MBL persists over time without clinical progression, although carrying the same cytogenetic abnormalities of CLL [作者：Fazi, C; Scarfo, L; Pecciarini, L; Cottini, F; Dagklis, A; Janus, A; Talarico, A; Scielzo, C; Sala, C; Toniolo, D; Caligaris-Cappio, F; Ghia, P,期刊：Blood, 页码：6618-6625 , 文章类型： Article，,卷期：2011年118-25] Monoclonal B-cell lymphocytosis (MBL) is classified as chronic lymphocytic leukemia (CLL)-like, atypical CLL, and CD5(-) MBL. The number of B cells per microliter divides CLL-like MBL into MBL associated with lymphocytos...