- Human ovarian cancer stem/progenitor cells are stimulated by doxorubicin but inhibited by Mullerian inhibiting substance
[作者:Meirelles, K; Benedict, LA; Dombkowski, D; Pepin, D; Preffer, FI; Teixeira, J; Tanwar, PS; Young, RH; MacLaughlin, DT; Donahoe, PK; Wei, XL,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2358-2363 , 文章类型: Article,,卷期:2012年109-7]
- Women with late-stage ovarian cancer usually develop chemotherapeutic-resistant recurrence. It has been theorized that a rare cancer stem cell, which is responsible for the growth and maintenance of the tumor, is also re...
- Characterization of thrombopoietin (TPO)-responsive progenitor cells in adult mouse bone marrow with in vivo megakaryocyte and erythroid potential
[作者:Ng, AP; Kauppi, M; Metcalf, D; Di Rago, L; Hyland, CD; Alexander, WS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2364-2369 , 文章类型: Article,,卷期:2012年109-7]
- Hematopoietic progenitor cells are the progeny of hematopoietic stem cells that coordinate the production of precise numbers of mature blood cells of diverse functional lineages. Identification of cell-surface antigen ex...
- Vezf1 protein binding sites genome-wide are associated with pausing of elongating RNA polymerase II
[作者:Gowher, H; Brick, K; Camerini-Otero, RD; Felsenfeld, G,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2370-2375 , 文章类型: Article,,卷期:2012年109-7]
- The protein Vezf1 plays multiple roles important for embryonic development. In Vezf1(-/-) mouse embryonic stem (mES) cells, our earlier data showed widespread changes in gene-expression profiles, including decreased expr...
- Quantitative modeling of the terminal differentiation of B cells and mechanisms of lymphomagenesis
[作者:Martinez, MR; Corradin, A; Klein, U; Alvarez, MJ; Toffolo, GM; di Camillo, B; Califano, A; Stolovitzky, GA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2672-2677 , 文章类型: Article,,卷期:2012年109-7]
- Mature B-cell exit fromgerminal centers is controlled by a transcriptional regulatory module that integrates antigen and T-cell signals and, ultimately, leads to terminal differentiation into memory B cells or plasma cel...
- Ancestral capture of syncytin-Car1, a fusogenic endogenous retroviral envelope gene involved in placentation and conserved in Carnivora
[作者:Cornelis, G; Heidmann, O; Bernard-Stoecklin, S; Reynaud, K; Veron, G; Mulot, B; Dupressoir, A; Heidmann, T,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E432-E441 , 文章类型: Article,,卷期:2012年109-7]
- Syncytins are envelope protein genes of retroviral origin that have been captured for a function in placentation. Two such genes have already been identified in simians, two distinct, unrelated genes have been identified...
- Glucose activates free fatty acid receptor 1 gene transcription via phosphatidylinositol-3-kinase-dependent O-GlcNAcylation of pancreas-duodenum homeobox-1
[作者:Kebede, M; Ferdaoussi, M; Mancini, A; Alquier, T; Kulkarni, RN; Walker, MD; Poitout, V,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2376-2381 , 文章类型: Article,,卷期:2012年109-7]
- The G protein-coupled free fatty acid receptor-1 (FFA1/GPR40) plays a major role in the regulation of insulin secretion by fatty acids. GPR40 is considered a potential therapeutic target to enhance insulin secretion in t...
- Mitochondrial ubiquitin ligase MITOL blocks S-nitrosylated MAP1B-light chain 1-mediated mitochondrial dysfunction and neuronal cell death
[作者:Yonashiro, R; Kimijima, Y; Shimura, T; Kawaguchi, K; Fukuda, T; Inatome, R; Yanagi, S,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2382-2387 , 文章类型: Article,,卷期:2012年109-7]
- Nitric oxide (NO) is implicated in neuronal cell survival. However, excessive NO production mediates neuronal cell death, in part via mitochondrial dysfunction. Here, we report that the mitochondrial ubiquitin ligase, MI...
- Kinesin-2 family in vertebrate ciliogenesis
[作者:Zhao, CT; Omori, Y; Brodowska, K; Kovach, P; Malicki, J,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2388-2393 , 文章类型: Article,,卷期:2012年109-7]
- The differentiation of cilia is mediated by kinesin-driven transport. As the function of kinesins in vertebrate ciliogenesis is poorly characterized, we decided to determine the role of kinesin-2 family motors-heterotrim...
- Asynchronous Ca2+ current conducted by voltage-gated Ca2+ (Ca-V)-2.1 and Ca(V)2.2 channels and its implications for asynchronous neurotransmitter release
[作者:Few, AP; Nanou, E; Watari, H; Sullivan, JM; Scheuer, T; Catterall, WA,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E452-E460 , 文章类型: Article,,卷期:2012年109-7]
- We have identified an asynchronously activated Ca2+ current through voltage-gated Ca2+ (Ca-V)-2.1 and Ca(V)2.2 channels, which conduct P/Q- and N-type Ca2+ currents that initiate neurotransmitter release. In nonneuronal ...
- Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA
[作者:Jung, HJ; Coffinier, C; Choe, Y; Beigneux, AP; Davies, BSJ; Yang, SH; Barnes, RH; Hong, J; Sun, T; Pleasure, SJ; Young, SG; Fong, LG,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E423-E431 , 文章类型: Article,,卷期:2012年109-7]
- Lamins A and C, alternatively spliced products of the LMNA gene, are key components of the nuclear lamina. The two isoforms are found in similar amounts in most tissues, but we observed an unexpected pattern of expressio...
- Critical role for protein kinase A in the acquisition of gregarious behavior in the desert locust
[作者:Ott, SR; Verlinden, H; Rogers, SM; Brighton, CH; Quah, PS; Vleugels, RK; Verdonck, R; Vanden Broeck, J,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E381-E387 , 文章类型: Article,,卷期:2012年109-7]
- The mechanisms that integrate genetic and environmental information to coordinate the expression of complex phenotypes are little understood. We investigated the role of two protein kinases (PKs) in the population densit...
- YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy
[作者:von Gise, A; Lin, ZQ; Schlegelmilch, K; Honor, LB; Pan, GM; Buck, JN; Ma, Q; Ishiwata, T; Zhou, B; Camargo, FD; Pu, WT,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:2394-2399 , 文章类型: Article,,卷期:2012年109-7]
- Heart growth is tightly controlled so that the heart reaches a predetermined size. Fetal heart growth occurs through cardiomyocyte proliferation, whereas postnatal heart growth involves primarily physiological cardiomyoc...
- Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity
[作者:Partanen, JI; Tervonen, TA; Myllynen, M; Lind, E; Imai, M; Katajisto, P; Dijkgraaf, GJP; Kovanen, PE; Makela, TP; Werb, Z; Klefstrom, J,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E388-E397 , 文章类型: Article,,卷期:2012年109-7]
- Although loss of epithelial integrity is a hallmark of advanced cancer, it remains poorly understood whether genetic alterations corrupting this integrity causally facilitate tumorigenesis. We show that conditional delet...
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