- Targeted deletion of PTEN in smooth muscle cells results in vascular remodeling and recruitment of progenitor cells through induction of stromal cell-derived factor-1 alpha
[作者：Nemenoff, RA; Simpson, PA; Furgeson, SB; Kaplan-Albuquerque, N; Crossno, J; Garl, PJ; Cooper, J; Weiser-Evans, MCM,期刊：Circulation Research, 页码：1036-1045 , 文章类型： Article，,卷期：2008年102-9]
- We previously showed that changes in vascular smooth muscle cell (SMC) PTEN/Akt signaling following vascular injury are associated with increased SMC proliferation and neointima formation. In this report, we used a genet...
- An acyltransferase controls the generation of hematopoietic and endothelial lineages in zebrafish
[作者：Xiong, JW; Yu, QM; Zhang, JJ; Mably, JD,期刊：Circulation Research, 页码：1057-1064 , 文章类型： Article，,卷期：2008年102-9]
- Hematopoietic and endothelial cells develop from a common progenitor, the hemangioblast, or directly from mesodermal cells. The molecular pathway that regulates the specification of both cell lineages remains elusive. He...
- IP3 constricts cerebral arteries via IP3 receptor-mediated TRPC3 channel activation and independently of sarcoplasmic reticulum Ca2+ release
[作者：Xi, Q; Adebiyi, A; Zhao, GL; Chapman, KE; Waters, CM; Hassid, A; Jaggar, JH,期刊：Circulation Research, 页码：1118-1126 , 文章类型： Article，,卷期：2008年102-9]
- Vasoconstrictors that bind to phospholipase C-coupled receptors elevate inositol-1,4,5-trisphosphate (IP3). IP3 is generally considered to elevate intracellular Ca2+ concentration ([Ca2+](i)) in arterial myocytes and ind...
- Activation of Notch-mediated protective signaling in the myocardium
[作者：Gude, NA; Emmanuel, G; Wu, WT; Cottage, CT; Fischer, K; Quijada, P; Muraski, JA; Alvarez, R; Rubio, M; Schaefer, E; Sussman, MA,期刊：Circulation Research, 页码：1025-1035 , 文章类型： Article，,卷期：2008年102-9]
- The Notch network regulates multiple cellular processes, including cell fate determination, development, differentiation, proliferation, apoptosis, and regeneration. These processes are regulated via Notch-mediated activ...
- Hypoxia-inducible factor-2 alpha transactivates Abcg2 and promotes cytoprotection in cardiac side population cells
[作者：Martin, CM; Ferdous, A; Gallardo, T; Humphries, C; Sadek, H; Caprioli, A; Garcia, JA; Szweda, LI; Garry, MG; Garry, DJ,期刊：Circulation Research, 页码：1075-1081 , 文章类型： Article，,卷期：2008年102-9]
- Stem and progenitor cell populations occupy a specialized niche and are consequently exposed to hypoxic as well as oxidative stresses. We have previously established that the multidrug resistance protein Abcg2 is the mol...
- Combined deficiency of dystrophin and beta 1 integrin in the cardiac myocyte causes myocardial dysfunction, fibrosis and calcification
[作者：Elsherif, L; Huang, MS; Shai, SY; Yang, Y; Li, RY; Chun, J; Mekany, MA; Chu, AL; Kaufman, SJ; Ross, RS,期刊：Circulation Research, 页码：1109-1117 , 文章类型： Article，,卷期：2008年102-9]
- The dystrophin-glycoprotein complex is a large complex of membrane-associated proteins linking the cytoskeleton to the extracellular matrix in muscle. Transmembrane heterodimeric (alpha beta) integrins serve also as cell...
- Sex, age, and regional differences in L-type calcium current are important determinants of arrhythmia phenotype in rabbit hearts with drug-induced long QT type 2
[作者：Sims, C; Reisenweber, S; Viswanathan, PC; Choi, BR; Walker, WH; Salama, G,期刊：Circulation Research, 页码：E86-E100 , 文章类型： Article，,卷期：2008年102-9]
- In congenital and acquired long QT type 2, women are more vulnerable than men to Torsade de Pointes. In prepubertal rabbits (and children), the arrhythmia phenotype is reversed; however, females still have longer action ...
- Inhibition of mitochondrial permeability transition pore opening by ischemic preconditioning is probably mediated by reduction of oxidative stress rather than mitochondrial protein phosphorylation
[作者：Clarke, SJ; Khaliulin, I; Das, M; Parker, JE; Heesom, KJ; Halestrap, AP,期刊：Circulation Research, 页码：1082-1090 , 文章类型： Article，,卷期：2008年102-9]
- Inhibition of mitochondrial permeability transition pore (MPTP) opening at reperfusion is critical for cardioprotection by ischemic preconditioning (IP). Some studies have implicated mitochondrial protein phosphorylation...
- Spatiotemporal dynamics of beta-adrenergic cAMP signals and L-type Ca2+ channel regulation in adult rat ventricular myocytes - Role of Phosphodiesterases
[作者：Leroy, J; Abi-Gerges, A; Nikolaev, VO; Richter, W; Lechene, P; Mazet, JL; Conti, M; Fischmeister, R; Vandecasteele, G,期刊：Circulation Research, 页码：1091-1100 , 文章类型： Article，,卷期：2008年102-9]
- Steady-state activation of cardiac beta-adrenergic receptors leads to an intracellular compartmentation of cAMP resulting from localized cyclic nucleotide phosphodiesterase (PDE) activity. To evaluate the time course of ...
- Salt-sensitive hypertension induced by decoy of transcription factor hypoxia-inducible factor-1 alpha in the renal medulla
[作者：Li, NJ; Chen, L; Yi, F; Xia, M; Li, PL,期刊：Circulation Research, 页码：1101-1108 , 文章类型： Article，,卷期：2008年102-9]
- Hypoxia inducible factor (HIF)-1 alpha, a transcription factor, is abundantly expressed in the renal medulla and regulates many oxygen-sensitive genes such as nitric oxide synthase, cyclooxygenase-2, and heme oxygenase-1...
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