- Interferon-beta signaling is enhanced in patients with insufficient coronary collateral artery development and inhibits arteriogenesis in mice
[作者:Schirmer, SH; Fledderus, JO; Bot, PTG; Moerland, PD; Hoefer, IE; Baan, J; Henriques, JPS; van der Schaaf, RJ; Vis, MM; Horrevoets, AJG; Piek, JJ; van Royen, N,期刊:Circulation Research, 页码:1286-1294 , 文章类型: Article,,卷期:2008年102-10]
- Stimulation of collateral artery growth in patients has been hitherto unsuccessful, despite promising experimental approaches. Circulating monocytes are involved in the growth of collateral arteries, a process also refer...
- ADAM10 regulates endothelial permeability and T-cell transmigration by proteolysis of vascular endothelial cadherin
[作者:Schulz, B; Pruessmeyer, J; Maretzky, T; Ludwig, A; Blobel, CP; Saftig, P; Reiss, K,期刊:Circulation Research, 页码:1192-1201 , 文章类型: Article,,卷期:2008年102-10]
- Vascular endothelial (VE)-cadherin is the major adhesion molecule of endothelial adherens junctions. It plays an essential role in controlling endothelial permeability, vascular integrity, leukocyte transmigration, and a...
- Mutations in bone morphogenetic protein type II receptor cause dysregulation of Id gene expression in pulmonary artery smooth muscle cells - Implications for familial pulmonary arterial hypertension
[作者:Yang, J; Davies, RJ; Southwood, M; Long, L; Yang, XD; Sobolewski, A; Upton, PD; Trembath, RC; Morrell, NW,期刊:Circulation Research, 页码:1212-1221 , 文章类型: Article,,卷期:2008年102-10]
- Heterozygous germ line mutations in the gene encoding the bone morphogenetic protein (BMP) type II receptor occur in more than 80% of patients with familial pulmonary arterial hypertension. Because inhibitors of DNA bind...
- Heparin-binding epidermal growth factor-like growth factor signaling in flow-induced arterial remodeling
[作者:Zhang, H; Sunnarborg, SW; McNaughton, KK; Johns, TG; Lee, DC; Faber, JE,期刊:Circulation Research, 页码:1275-1285 , 文章类型: Article,,卷期:2008年102-10]
- Heparin-binding epidermal growth factor (EGF)-like growth factor (HB-EGF) is activated by reduced endothelial shear stress and stimulates smooth muscle cell proliferation in vitro. Moreover, HB-EGF is augmented at sites ...
- Role of protein tyrosine phosphatase 1B in vascular endothelial growth factor signaling and cell-cell adhesions in endothelial cells
[作者:Nakamura, Y; Patrushev, N; Inomata, H; Mehta, D; Urao, N; Kim, HW; Razvi, M; Kini, V; Mahadev, K; Goldstein, BJ; McKinney, R; Fukai, T; Ushio-Fukai, M,期刊:Circulation Research, 页码:1182-1191 , 文章类型: Article,,卷期:2008年102-10]
- Vascular endothelial growth factor (VEGF) binding induces phosphorylation of VEGF receptor (VEGFR) 2 in tyrosine, which is followed by disruption of VE-cadherin-mediated cell-cell contacts of endothelial cells (ECs), the...
- Discoidin domain receptor 1 (Ddr1) deletion decreases atherosclerosis by accelerating matrix accumulation and reducing inflammation in low-density lipoprotein receptor-deficient mice
[作者:Franco, C; Hou, GP; Ahmad, PJ; Fu, EYK; Koh, L; Vogel, WF; Bendeck, MP,期刊:Circulation Research, 页码:1202-1211 , 文章类型: Article,,卷期:2008年102-10]
- Collagens are abundant within the atherosclerotic plaque, where they contribute to lesion volume and mechanical stability and influence cell signaling. The discoidin domain receptor 1 (DDR1), a receptor tyrosine kinase t...
- A cyclin D2-Rb pathway regulates cardiac myocyte size and RNA polymerase III after biomechanical stress in adult myocardium
[作者:Angelis, E; Garcia, A; Chan, SS; Schenke-Layland, K; Ren, SX; Goodfellow, SJ; Jordan, MC; Roos, KP; White, RJ; MacLellan, WR,期刊:Circulation Research, 页码:1222-1229 , 文章类型: Article,,卷期:2008年102-10]
- Normally, cell cycle progression is tightly coupled to the accumulation of cell mass; however, the mechanisms whereby proliferation and cell growth are linked are poorly understood. We have identified cyclin (Cyc) D2, a ...
- Chromogranin B regulates calcium signaling, nuclear factor kappa B activity, and brain natriuretic peptide production in cardiomyocytes
[作者:Heidrich, FM; Zhang, K; Estrada, M; Huang, Y; Giordano, FJ; Ehrlich, BE,期刊:Circulation Research, 页码:1230-1238 , 文章类型: Article,,卷期:2008年102-10]
- Altered regulation of signaling pathways can lead to pathologies including cardiac hypertrophy and heart failure. We report that neonatal and adult cardiomyocytes express chromogranin B (CGB), a Ca2+ binding protein that...
- Intramural foci during long duration fibrillation in the pig ventricle
[作者:Li, L; Jin, Q; Huang, J; Cheng, KA; Ideker, RE,期刊:Circulation Research, 页码:1256-1264 , 文章类型: Article,,卷期:2008年102-10]
- For more than 50 years, it has been assumed that ventricular fibrillation (VF) is maintained solely by reentry in the working myocardium. This hypothesis has never been tested by recording VF with electrodes spaced suffi...
- Ste20-related kinase SLK phosphorylates Ser188 of RhoA to induce vasodilation in response to angiotensin II type 2 receptor activation
[作者:Guilluy, C; Rolli-Derkinderen, M; Loufrani, L; Bourge, A; Henrion, D; Sabourin, L; Loirand, G; Pacaud, P,期刊:Circulation Research, 页码:1265-1274 , 文章类型: Article,,卷期:2008年102-10]
- The small G protein Rho signaling pathways are recognized as major regulators of cardiovascular functions, and activation of Rho proteins appears to be a common component for the pathogenesis of hypertension and vascular...
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