- Tumor necrosis factor-alpha downregulates endothelial nitric oxide synthase mRNA stability via translation elongation factor 1-alpha 1
[作者：Yan, GJ; You, B; Chen, SP; Liao, JK; Sun, JX,期刊：Circulation Research, 页码：591-597 , 文章类型： Article，,卷期：2008年103-6]
- Endothelium-derived nitric oxide (NO) is an important regulator of vascular function. NO is produced by endothelial NO synthase (eNOS), whose expression is downregulated by tumor necrosis factor (TNF)-alpha at the posttr...
- Peroxiredoxin1 prevents excessive endothelial activation and early atherosclerosis
[作者：Kisucka, J; Chauhan, AK; Patten, IS; Yesilaltay, A; Neumann, C; Van Etten, RA; Krieger, M; Wagner, DD,期刊：Circulation Research, 页码：598-605 , 文章类型： Article，,卷期：2008年103-6]
- The peroxiredoxin (Prdx) family of antioxidant enzymes uses redox-active cysteines to reduce peroxides, lipid hydroperoxides, and peroxynitrites. Prdx1 is known to be important to protect red blood cells against reactive...
- Nitroglycerin-induced S-nitrosylation and desensitization of soluble guanylyl cyclase contribute to nitrate tolerance
[作者：Sayed, N; Kim, DD; Fioramonti, X; Iwahashi, T; Duran, WN; Beuve, A,期刊：Circulation Research, 页码：606-614 , 文章类型： Article，,卷期：2008年103-6]
- Nitrates such as nitroglycerin (GTN) and nitric oxide donors such as S-nitrosothiols are clinically vasoactive through stimulation of soluble guanylyl cyclase (sGC), which produces the second messenger cGMP. Development ...
- Perinatal loss of Nkx2-5 results in rapid conduction and contraction defects
[作者：Briggs, LE; Takeda, M; Cuadra, AE; Wakimoto, H; Marks, MH; Walker, AJ; Seki, T; Oh, SP; Lu, JT; Sumners, C; Raizada, MK; Horikoshi, N; Weinberg, EO; Yasui, K; Ikeda, Y; Chien, KR; Kasahara, H,期刊：Circulation Research, 页码：580-590 , 文章类型： Article，,卷期：2008年103-6]
- Homeobox transcription factor Nkx2-5, highly expressed in heart, is a critical factor during early embryonic cardiac development. In this study, using tamoxifen-inducible Nkx2-5 knockout mice, we demonstrate the role of ...
- Phosphatidylinositol 3-kinase gamma is a critical mediator of myocardial ischemic and adenosine-mediated preconditioning
[作者：Ban, K; Cooper, AJ; Samuel, S; Bhatti, A; Patel, M; Izumo, S; Penninger, JM; Backx, PH; Oudit, GY; Tsushima, RG,期刊：Circulation Research, 页码：643-653 , 文章类型： Article，,卷期：2008年103-6]
- Ischemic preconditioning (IPC) is a potent cellular protective mechanism whereby brief periods of sublethal ischemia protect the myocardium from prolonged ischemia-induced injury. We demonstrate the selective role of pho...
- Role of the lysine-specific demethylase 1 in the proinflammatory phenotype of vascular smooth muscle cells of diabetic mice
[作者：Reddy, MA; Villeneuve, LM; Wang, M; Lanting, L; Natarajan, R,期刊：Circulation Research, 页码：615-623 , 文章类型： Article，,卷期：2008年103-6]
- Insulin resistance and type 2 diabetes are major risk factors for vascular complications. Vascular smooth muscle cells (VSMCs) derived from db/db mice, an established mouse model of type 2 diabetes, displayed enhanced in...
- Endothelium-specific interference with peroxisome proliferator activated receptor gamma causes cerebral vascular dysfunction in response to a high-fat diet
[作者：Beyer, AM; de Lange, WJ; Halabi, CM; Modrick, ML; Keen, HL; Faraci, FM; Sigmund, CD,期刊：Circulation Research, 页码：654-661 , 文章类型： Article，,卷期：2008年103-6]
- The ligand-activated transcription factor peroxisome proliferator activated receptor gamma (PPAR gamma) is expressed in vascular endothelium where it exerts anti-inflammatory and antioxidant effects. However, its role in...
- The helix-loop-helix factors Id3 and E47 are novel regulators of adiponectin
[作者：Doran, AC; Meller, N; Cutchins, A; Deliri, H; Slayton, RP; Oldham, SN; Kim, JB; Keller, SR; McNamara, CA,期刊：Circulation Research, 页码：624-634 , 文章类型： Article，,卷期：2008年103-6]
- Adiponectin is an adipocyte-derived cytokine with beneficial effects on insulin sensitivity and the development of atherosclerosis. Id3 is a helix-loop-helix factor that binds to E-proteins such as E47 and inhibits their...
- Lysophosphatidic acid receptors 1 and 2 play roles in regulation of vascular injury responses but not blood pressure
[作者：Panchatcharam, M; Miriyala, S; Yang, F; Rojas, M; End, C; Vallant, C; Dong, A; Lynch, K; Chun, J; Morris, AJ; Smyth, SS,期刊：Circulation Research, 页码：662-670 , 文章类型： Article，,卷期：2008年103-6]
- Phenotypic modulation of vascular smooth muscle cells (SMCs) is essential for the development of intimal hyperplasia. Lysophosphatidic acid (LPA) is a serum component that can promote phenotypic modulation of cultured SM...
- A Rho kinase/myocardin-related transcription factor-A-dependent mechanism underlies the sphingosylphosphorylcholine-induced differentiation of mesenchymal stem cells into contractile smooth muscle cells
[作者：Jeon, ES; Park, WS; Lee, MJ; Kim, YM; Han, J; Kim, JH,期刊：Circulation Research, 页码：635-642 , 文章类型： Article，,卷期：2008年103-6]
- Sphingosylphosphorylcholine (SPC) induces differentiation of human adipose tissue-derived mesenchymal stem cells (hADSCs) to smooth muscle cells (SMCs). In the present study, we characterized contractile and ion channel ...
- Vascular endothelial growth factor and semaphorin induce neuropilin-1 endocytosis via separate pathways
[作者：Salikhova, A; Wang, L; Lanahan, AA; Liu, M; Simons, M; Leenders, WPJ; Mukhopadhyay, D; Horowitz, A,期刊：Circulation Research, 页码：E71-E79 , 文章类型： Article，,卷期：2008年103-6]
- The neuropilin (Nrp) 1 receptor is essential for both nervous and vascular system development. Nrp1 is unusually versatile, because it transmits both chemoattractive and repulsive signals in response to vascular endothel...
- Reactive oxygen species-induced activation of P90ribosomal S6 kinase prolongs cardiac repolarization through inhibiting outward K-channel activity (vol 103, pg 269, 2008)
[作者：Lu, Z; Abe, JI; Taunton, J; Lu, Y; Shishido, T; McClain, C; Yan, C; Xu, SP; Spangenberg, TM; Xu, HD,期刊：Circulation Research, 页码：E80-E80 , 文章类型： Correction，,卷期：2008年103-6]
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