- Mechanisms underlying rate-dependent remodeling of transient outward potassium current in canine ventricular myocytes
[作者：Xiao, L; Coutu, P; Villeneuve, LR; Tadevosyan, A; Maguy, A; Le Bouter, S; Allen, BG; Nattel, S,期刊：Circulation Research, 页码：733-742 , 文章类型： Article，,卷期：2008年103-7]
- Transient outward K+ current (I-to) downregulation following sustained tachycardia in vivo is usually attributed to tachycardiomyopathy. This study assessed potential direct rate regulation of cardiac I-to and underlying...
- E-cadherin/beta-catenin/T-cell factor pathway is involved in smooth muscle cell proliferation elicited by oxidized low-density lipoprotein
[作者：Bedel, A; Negre-Salvayre, A; Heeneman, S; Grazide, MH; Thiers, JC; Salvayre, R; Maupas-Schwalm, F,期刊：Circulation Research, 页码：694-701 , 文章类型： Article，,卷期：2008年103-7]
- The E-cadherin/beta-catenin/T-cell factor (Tcf) signaling pathway plays a crucial role in embryogenesis and carcinogenesis and has recently emerged in atherosclerosis. The aim of this work was to investigate whether this...
- Tbx3 is required for outflow tract development
[作者：Mesbah, K; Harrelson, Z; Theveniau-Ruissy, M; Papaioannou, VE; Kelly, RG,期刊：Circulation Research, 页码：743-750 , 文章类型： Article，,卷期：2008年103-7]
- Conotruncal and ventricular septal congenital heart anomalies result from defects in formation and division of the embryonic outflow tract. Cardiac remodeling during outflow tract and ventricular septation converts the t...
- Pbx/Meis deficiencies demonstrate multigenetic origins of congenital heart disease
[作者：Stankunas, K; Shang, C; Twu, KY; Kao, SC; Jenkins, NA; Copeland, NG; Sanyal, M; Selleri, L; Cleary, ML; Chang, CP,期刊：Circulation Research, 页码：702-709 , 文章类型： Article，,卷期：2008年103-7]
- Congenital heart diseases are traditionally considered to be multifactorial in pathogenesis resulting from environmental and genetic interactions that determine penetrance and expressivity within a genetically predispose...
- Syx, a RhoA guanine exchange factor, is essential for angiogenesis in vivo
[作者：Garnaas, MK; Moodie, KL; Liu, ML; Samant, GV; Li, K; Marx, R; Baraban, JM; Horowitz, A; Ramchandran, R,期刊：Circulation Research, 页码：710-716 , 文章类型： Article，,卷期：2008年103-7]
- Rho GTPases play an important and versatile role in several biological processes. In this study, we identified the zebrafish ortholog of the mammalian Rho A guanine exchange factor, synectin-binding guanine exchange fact...
- Coadministration of endothelial and smooth muscle progenitor cells enhances the efficiency of proangiogenic cell-based therapy
[作者：Foubert, P; Matrone, G; Souttou, B; Lere-Dean, C; Barateau, V; Plouet, J; Le Ricousse-Roussanne, S; Levy, BI; Silvestre, JS; Tobelem, G,期刊：Circulation Research, 页码：751-760 , 文章类型： Article，,卷期：2008年103-7]
- Cell-based therapy is a promising approach designed to enhance neovascularization and function of ischemic tissues. Interaction between endothelial and smooth muscle cells regulates vessels development and remodeling and...
- Statins use a novel Nijmegen breakage syndrome-1-dependent pathway to accelerate DNA repair in vascular smooth muscle cells
[作者：Mahmoudi, M; Gorenne, I; Mercer, J; Figg, N; Littlewood, T; Bennett, M,期刊：Circulation Research, 页码：717-725 , 文章类型： Article，,卷期：2008年103-7]
- Although the hydroxymethylglutaryl-coenzyme A reductase inhibitors (statins) are widely used in atherosclerosis to reduce serum cholesterol, statins have multiple other effects, including direct effects on cells of the v...
- Chronic hypoxia-induced angiogenesis normalizes blood pressure in spontaneously hypertensive rats
[作者：Vilar, J; Waeckel, L; Bonnin, P; Cochain, C; Loinard, C; Duriez, M; Silvestre, JS; Levy, BI,期刊：Circulation Research, 页码：761-769 , 文章类型： Article，,卷期：2008年103-7]
- We hypothesized that activation of angiogenesis by chronic hypoxia may affect vascular resistance and, subsequently, blood pressure levels in spontaneously hypertensive rats (SHRs). Five-week-old prehypertensive SHRs and...
- Increased endothelial mitogen-activated protein kinase phosphatase-1 expression suppresses proinflammatory activation at sites that are resistant to atherosclerosis
[作者：Zakkar, M; Chaudhury, H; Sandvik, G; Enesa, K; Luong, LA; Cuhlmann, S; Mason, JC; Krams, R; Clark, AR; Haskard, DO; Evans, PC,期刊：Circulation Research, 页码：726-732 , 文章类型： Article，,卷期：2008年103-7]
- Atherosclerosis is a chronic inflammatory disease of arteries. It is triggered by proinflammatory mediators which induce adhesion molecules (eg, vascular cell adhesion molecule [VCAM]-1) in endothelial cells (ECs) by act...
- Physiological properties of hERG 1a/1b heteromeric currents and a hERG 1b-specific mutation associated with long-QT syndrome
[作者：Sale, H; Wang, JL; O'Hara, TJ; Tester, DJ; Phartiyal, P; He, JQ; Rudy, Y; Ackerman, MJ; Robertson, GA,期刊：Circulation Research, 页码：E81-E95 , 文章类型： Article，,卷期：2008年103-7]
- Cardiac I-Kr is a critical repolarizing current in the heart and a target for inherited and acquired long-QT syndrome (LQTS). Biochemical and functional studies have demonstrated that I-Kr channels are heteromers compose...
- Hemizygous deficiency of Kruppel-like factor 2 augments experimental atherosclerosis
[作者：Atkins, GB; Wang, YM; Mahabeleshwar, GH; Shi, H; Gao, HY; Kawanami, DJ; Natesan, V; Lin, ZY; Simon, DI; Jain, MK,期刊：Circulation Research, 页码：690-693 , 文章类型： Editorial Material，,卷期：2008年103-7]
- Kruppel-like factor (KLF)2 is a central regulator of endothelial and monocyte/macrophage gene expression and function in vitro. Although the composite effects of KLF2 in these 2 cell types predict that it likely inhibits...
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