- Shp2 negatively regulates growth in cardiomyocytes by controlling focal adhesion kinase/Src and mTOR pathways
[作者:Marin, TM; Clemente, CFMZ; Santos, AM; Picardi, PK; Pascoal, VDB; Lopes-Cendes, I; Saad, MJA; Franchini, KG,期刊:Circulation Research, 页码:813-U90 , 文章类型: Article,,卷期:2008年103-8]
- The aim of this study was to investigate whether Shp2 (Src homology region 2, phosphatase 2) controls focal adhesion kinase (FAK) activity and its trophic actions in cardiomyocytes. We show that low phosphorylation level...
- Role of the ATP-binding cassette transporter Abcg2 in the phenotype and function of cardiac side population cells
[作者:Pfister, O; Oikonomopoulos, A; Sereti, KI; Sohn, RL; Cullen, D; Fine, GC; Mouquet, F; Westerman, K; Liao, R,期刊:Circulation Research, 页码:825-U110 , 文章类型: Article,,卷期:2008年103-8]
- Recently, the side population (SP) phenotype has been introduced as a reliable marker to identify subpopulations of cells with stem/progenitor cell properties in various tissues. We and others have identified SP cells fr...
- Protein kinase a type I and type II define distinct intracellular signaling compartments
[作者:Di Benedetto, G; Zoccarato, A; Lissandron, V; Terrin, A; Li, X; Houslay, MD; Baillie, GS; Zaccolo, M,期刊:Circulation Research, 页码:836-844 , 文章类型: Article,,卷期:2008年103-8]
- Protein kinase A (PKA) is a key regulatory enzyme that, on activation by cAMP, modulates a wide variety of cellular functions. PKA isoforms type I and type II possess different structural features and biochemical charact...
- Cellular signaling underlying atrial tachycardia remodeling of L-type calcium current
[作者:Qi, XY; Yeh, YH; Xiao, L; Burstein, B; Maguy, A; Chartier, D; Villeneuve, LR; Brundel, BJJM; Dobrev, D; Nattel, S,期刊:Circulation Research, 页码:845-U151 , 文章类型: Article,,卷期:2008年103-8]
- Atrial tachycardia (AT) downregulates L-type Ca2+ current (I-CaL) and causes atrial fibrillation -promoting electric remodeling. This study assessed potential underlying signal transduction. Cultured adult canine atrial ...
- Cytoskeletal protein 4.1R affects repolarization and regulates calcium handling in the heart
[作者:Stagg, MA; Carter, E; Sohrabi, N; Siedlecka, U; Soppa, GK; Mead, F; Mohandas, N; Taylor-Harris, P; Baines, A; Bennett, P; Yacoub, MH; Pinder, JC; Terracciano, CMN,期刊:Circulation Research, 页码:855-U177 , 文章类型: Article,,卷期:2008年103-8]
- The 4.1 proteins are a family of multifunctional adaptor proteins. They promote the mechanical stability of plasma membranes by interaction with the cytoskeletal proteins spectrin and actin and are required for the cell ...
- The Wnt antagonist Dickkopf-1 mobilizes vasculogenic progenitor cells via activation of the bone marrow endosteal stem cell niche
[作者:Aicher, A; Kollet, O; Heeschen, C; Liebner, S; Urbich, C; Ihling, C; Orlandi, A; Lapidot, T; Zeiher, AM; Dimmeler, S,期刊:Circulation Research, 页码:796-U47 , 文章类型: Article,,卷期:2008年103-8]
- Therapeutic mobilization of vasculogenic progenitor cells is a novel strategy to enhance neovascularization for tissue repair. Prototypical mobilizing agents such as granulocyte colony-stimulating factor mobilize vasculo...
- Bestrophin-3 (vitelliform macular dystrophy 2-like 3 protein) is essential for the cGMP-dependent calcium-activated chloride conductance in vascular smooth muscle cells
[作者:Matchkov, VV; Larsen, P; Bouzinova, EV; Rojek, A; Boedtkjer, DMB; Golubinskaya, V; Pedersen, FS; Aalkjaer, C; Nilsson, H,期刊:Circulation Research, 页码:864-U212 , 文章类型: Article,,卷期:2008年103-8]
- Although the biophysical fingerprints (ion selectivity, voltage- dependence, kinetics, etc) of Ca2+-activated Cl- currents are well established, their molecular identity is still controversial. Several molecular candidat...
- BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesis
[作者:Heinke, J; Wehofsits, L; Zhou, Q; Zoeller, C; Baar, KM; Helbing, T; Laib, A; Augustin, H; Bode, C; Patterson, C; Moser, M,期刊:Circulation Research, 页码:804-U65 , 文章类型: Article,,卷期:2008年103-8]
- Bone morphogenetic proteins (BMPs) are involved in embryonic and adult blood vessel formation in health and disease. BMPER (BMP endothelial cell precursor -derived regulator) is a differentially expressed protein in embr...
- Activation of Na+/H+ exchanger 1 is sufficient to generate Ca2+ signals that induce cardiac hypertrophy and heart failure
[作者:Nakamura, TY; Iwata, Y; Arai, Y; Komamura, K; Wakabayashi, S,期刊:Circulation Research, 页码:891-U293 , 文章类型: Article,,卷期:2008年103-8]
- Activation of the sarcolemmal Na+/H+ exchanger (NHE) 1 is increasingly documented as a process involved in cardiac hypertrophy and heart failure. However, whether NHE1 activation alone is sufficient to induce such remode...
- Interactions, functions, and independence of plasma membrane STIM1 and TRPC1 in vascular smooth muscle cells
[作者:Li, J; Sukumar, P; Milligan, CJ; Kumar, B; Ma, ZY; Munsch, CM; Jiang, LH; Porter, KE; Beech, DJ,期刊:Circulation Research, 页码:E97-U311 , 文章类型: Article,,卷期:2008年103-8]
- Stromal interaction molecule 1 (STIM1) is a predicted single membrane -spanning protein involved in store-operated calcium entry and interacting with ion channels including TRPC1. Here, we focus on endogenous STIM1 of mo...
- Termination of cardiac Ca2+ sparks role of intra-SR [Ca2+], release flux, and intra-SR Ca2+ diffusion
[作者:Zima, AV; Picht, E; Bers, DM; Blatter, LA,期刊:Circulation Research, 页码:E105-E115 , 文章类型: Article,,卷期:2008年103-8]
- Ca2+ release from cardiac sarcoplasmic reticulum ( SR) via ryanodine receptors ( RyRs) is regulated by dyadic cleft [Ca2+] and intra-SR free [Ca2+] ([Ca2+](SR)). Robust SR Ca2+ release termination is important for stable...
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