- Essential Role of Developmentally Activated Hypoxia-Inducible Factor 1 alpha for Cardiac Morphogenesis and Function
[作者:Krishnan, J; Ahuja, P; Bodenmann, S; Knapik, D; Perriard, E; Krek, W; Perriard, JC,期刊:Circulation Research, 页码:1139-1146 , 文章类型: Article,,卷期:2008年103-10]
- Development of the mammalian heart is governed by precisely orchestrated interactions between signaling pathways integrating environmental cues and a core cardiac transcriptional network that directs differentiation, gro...
- Genome-Wide Analysis of the Zebrafish ETS Family Identifies Three Genes Required for Hemangioblast Differentiation or Angiogenesis
[作者:Liu, F; Patient, R,期刊:Circulation Research, 页码:1147-U194 , 文章类型: Article,,卷期:2008年103-10]
- ETS domain transcription factors have been linked to hematopoiesis, vasculogenesis, and angiogenesis. However, their biological functions and the mechanisms of action, remain incompletely understood. Here, we have perfor...
- The PPAR alpha/p16(INK4a) Pathway Inhibits Vascular Smooth Muscle Cell Proliferation by Repressing Cell Cycle-Dependent Telomerase Activation
[作者:Gizard, F; Nomiyama, T; Zhao, Y; Findeisen, HM; Heywood, EB; Jones, KL; Staels, B; Bruemmer, D,期刊:Circulation Research, 页码:1155-1163 , 文章类型: Article,,卷期:2008年103-10]
- Peroxisome proliferator-activated receptor (PPAR)alpha, the molecular target for fibrates used to treat dyslipidemia, exerts pleiotropic effects on vascular cells. In vascular smooth muscle cells (VSMCs), we have previou...
- Activation of Sphingosine Kinase-1 Reverses the Increase in Lung Vascular Permeability Through Sphingosine-1-Phosphate Receptor Signaling in Endothelial Cells
[作者:Tauseef, M; Kini, V; Knezevic, N; Brannan, M; Ramchandaran, R; Fyrst, H; Saba, J; Vogel, SM; Malik, AB; Mehta, D,期刊:Circulation Research, 页码:1164-U214 , 文章类型: Article,,卷期:2008年103-10]
- The lipid mediator sphingosine-1-phosphate (S1P), the product of sphingosine kinase (SPHK)-induced phosphorylation of sphingosine, is known to stabilize interendothelial junctions and prevent microvessel leakiness. Here,...
- Dyslipidemia and Atherosclerosis Induced by Chronic Intermittent Hypoxia Are Attenuated by Deficiency of Stearoyl Coenzyme A Desaturase
[作者:Savransky, V; Jun, J; Li, JG; Nanayakkara, A; Fonti, S; Moser, AB; Steele, KE; Schweitzer, MA; Patil, SP; Bhanot, S; Schwartz, AR; Polotsky, VY,期刊:Circulation Research, 页码:1173-U238 , 文章类型: Article,,卷期:2008年103-10]
- Obstructive sleep apnea leads to chronic intermittent hypoxia (CIH) and is associated with atherosclerosis. We have previously shown that C57BL/6J mice exposed to CIH and a high-cholesterol diet develop dyslipidemia, ath...
- Infusion of Reconstituted High-Density Lipoprotein Leads to Acute Changes in Human Atherosclerotic Plaque
[作者:Shaw, JA; Bobik, A; Murphy, A; Kanellakis, P; Blombery, P; Mukhamedova, N; Woollard, K; Lyon, S; Sviridov, D; Dart, AM,期刊:Circulation Research, 页码:1084-1091 , 文章类型: Article,,卷期:2008年103-10]
- Studies have shown a reduction in plaque volume and change in plaque ultrasound characteristics after 4 infusions of reconstituted high-density lipoprotein (rHDL). Whether rHDL infusion leads to acute changes in plaque c...
- Vascular Endothelial Growth Factor-A and Platelet-Derived Growth Factor-B Combination Gene Therapy Prolongs Angiogenic Effects via Recruitment of Interstitial Mononuclear Cells and Paracrine Effects Rather Than Improved Pericyte Coverage of Angiogenic Vessels
[作者:Korpisalo, P; Karvinen, H; Rissanen, TT; Kilpijoki, J; Marjomaki, V; Baluk, P; McDonald, DM; Cao, YH; Eriksson, U; Alitalo, K; Yla-Herttuala, S,期刊:Circulation Research, 页码:1092-U71 , 文章类型: Article,,卷期:2008年103-10]
- Vessel stabilization and the inhibition of side effects such as tissue edema are essential in angiogenic gene therapy. Thus, combination gene transfers stimulating both endothelial cell and pericyte proliferation have be...
- Adenosine 5 '-Tetraphosphate Is a Highly Potent Purinergic Endothelium-Derived Vasoconstrictor
[作者:Toelle, M; Jankowski, V; Schuchardt, M; Wiedon, A; Huang, T; Hub, F; Kowalska, J; Jemielity, J; Guranowski, A; Loddenkemper, C; Zidek, W; Jankowski, J; van der Giet, M,期刊:Circulation Research, 页码:1100-U93 , 文章类型: Article,,卷期:2008年103-10]
- Besides serving as a mechanical barrier, the endothelium has important regulatory functions. The discovery of nitric oxide revolutionized our understanding of vasoregulation. In contrast, the identity of endothelium-deri...
- Ca2+ Influx Through T- and L-Type Ca2+ Channels Have Different Effects on Myocyte Contractility and Induce Unique Cardiac Phenotypes
[作者:Jaleel, N; Nakayama, H; Chen, XW; Kubo, H; MacDonnell, S; Zhang, HY; Berretta, R; Robbins, J; Cribbs, L; Molkentin, JD; Houser, SR,期刊:Circulation Research, 页码:1109-U110 , 文章类型: Article,,卷期:2008年103-10]
- T-type Ca2+ channels (TTCCs) are expressed in the developing heart, are not present in the adult ventricle, and are reexpressed in cardiac diseases involving cardiac dysfunction and premature, arrhythmogenic death. The g...
- Pathophysiological Levels of Soluble P-Selectin Mediate Adhesion of Leukocytes to the Endothelium Through Mac-1 Activation
[作者:Woollard, KJ; Suhartoyo, A; Harris, EE; Eisenhardt, SU; Jackson, SP; Peter, K; Dart, AM; Hickey, MJ; Chin-Dusting, JPF,期刊:Circulation Research, 页码:1128-U175 , 文章类型: Article,,卷期:2008年103-10]
- Plasma soluble P-selectin (sP-selectin) levels are increased in pathologies associated with atherosclerosis, including peripheral arterial occlusive disease (PAOD). However, the role of sP-selectin in regulating leukocyt...
- Thrombospondin-1 Deficiency Accelerates Atherosclerotic Plaque Maturation in ApoE(-/-) Mice
[作者:Moura, R; Tjwa, M; Vandervoort, P; Van Kerckhoven, S; Holvoet, P; Hoylaerts, MF,期刊:Circulation Research, 页码:1181-U259 , 文章类型: Article,,卷期:2008年103-10]
- Thrombospondin (TSP)1 is implicated in various inflammatory processes, but its role in atherosclerotic plaque formation and progression is unclear. Therefore, the development of atherosclerosis was compared in ApoE(-/-) ...
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