- Atheroprotective Effect of Human Apolipoprotein A5 in a Mouse Model of Mixed Dyslipidemia
[作者:Mansouri, RM; Bauge, E; Gervois, P; Fruchart-Najib, J; Fievet, C; Staels, B; Fruchart, JC,期刊:Circulation Research, 页码:450-453 , 文章类型: Article,,卷期:2008年103-5]
- Hypertriglyceridemia is an independent risk factor for coronary artery disease. Because apolipoprotein (Apo) A5 regulates plasma triglyceride levels, we investigated the impact of human (h)ApoA5 on atherogenesis. The inf...
- Interferon-gamma, a Th1 Cytokine, Regulates Fat Inflammation A Role for Adaptive Immunity in Obesity
[作者:Rocha, VZ; Folco, EJ; Sukhova, G; Shimizu, K; Gotsman, I; Vernon, AH; Libby, P,期刊:Circulation Research, 页码:467-476 , 文章类型: Article,,卷期:2008年103-5]
- Adipose tissue (AT) can accumulate macrophages and secrete several inflammatory mediators. Despite its pivotal role in the progression of chronic inflammatory processes such as atherosclerosis, the adaptive role of immun...
- Increased FOG-2 in Failing Myocardium Disrupts Thyroid Hormone-Dependent SERCA2 Gene Transcription
[作者:Rouf, R; Greytak, S; Wooten, EC; Wu, J; Boltax, J; Picard, M; Svensson, EC; Dillmann, WH; Patten, RD; Huggins, GS,期刊:Circulation Research, 页码:493-501 , 文章类型: Article,,卷期:2008年103-5]
- Reduced expression of sarcoplasmic reticulum calcium ATPase (SERCA) 2 and other genes in the adult cardiac gene program has raised consideration of an impaired responsiveness to thyroid hormone (T3) that develops in the ...
- Corin Variant Associated With Hypertension and Cardiac Hypertrophy Exhibits Impaired Zymogen Activation and Natriuretic Peptide Processing Activity
[作者:Wang, W; Liao, XD; Fukuda, K; Knappe, S; Wu, F; Dries, DL; Qin, J; Wu, QY,期刊:Circulation Research, 页码:502-508 , 文章类型: Article,,卷期:2008年103-5]
- Corin is a cardiac serine protease that acts as the pro-atrial natriuretic peptide (ANP) convertase. Recently, 2 single-nucleotide polymorphisms (SNPs) (T555I and Q568P) in the human corin gene have been identified in ge...
- RXP-E A Connexin43-Binding Peptide That Prevents Action Potential Propagation Block
[作者:Lewandowski, R; Procida, K; Vaidyanathan, R; Coombs, W; Jalife, J; Nielsen, MS; Taffet, SM; Delmar, M,期刊:Circulation Research, 页码:519-526 , 文章类型: Article,,卷期:2008年103-5]
- Gap junctions provide a low-resistance pathway for cardiac electric propagation. The role of GJ regulation in arrhythmia is unclear, partly because of limited availability of pharmacological tools. Recently, we showed th...
- RGS4 Regulates Parasympathetic Signaling and Heart Rate Control in the Sinoatrial Node
[作者:Cifelli, C; Rose, RA; Zhang, HJ; Voigtlaender-Bolz, J; Bolz, SS; Backx, PH; Heximer, SP,期刊:Circulation Research, 页码:527-535 , 文章类型: Article,,卷期:2008年103-5]
- Heart rate is controlled by the opposing activities of sympathetic and parasympathetic inputs to pacemaker myocytes in the sinoatrial node (SAN). Parasympathetic activity on nodal myocytes is mediated by acetylcholine-de...
- Leptin Enhances the Recruitment of Endothelial Progenitor Cells Into Neointimal Lesions After Vascular Injury by Promoting Integrin-Mediated Adhesion
[作者:Schroeter, MR; Leifheit, M; Sudholt, P; Heida, NM; Dellas, C; Rohm, I; Alves, F; Zientkowska, M; Rafail, S; Puls, M; Hasenfuss, G; Konstantinides, S; Schafer, K,期刊:Circulation Research, 页码:536-544 , 文章类型: Article,,卷期:2008年103-5]
- The adipocytokine leptin modulates vascular remodeling and neointima formation. Because endothelial progenitor cells (EPCs) participate in vascular repair, we analyzed the effects of leptin on human EPC function in vitro...
- Calcium Phosphate Crystals Induce Cell Death in Human Vascular Smooth Muscle Cells A Potential Mechanism in Atherosclerotic Plaque Destabilization
[作者:Ewence, AE; Bootman, M; Roderick, HL; Skepper, JN; McCarthy, G; Epple, M; Neumann, M; Shanahan, CM; Proudfoot, D,期刊:Circulation Research, 页码:E28-E34 , 文章类型: Article,,卷期:2008年103-5]
- Vascular calcification is associated with an increased risk of myocardial infarction; however, the mechanisms linking these 2 processes are unknown. Studies in macrophages have suggested that calcium phosphate crystals i...
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