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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共32条记录   A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice [作者：Eckle, T; Grenz, A; Laucher, S; Eltzschig, HK,期刊：Journal of clinical investigation, 页码：3301-3315 , 文章类型： Article，,卷期：2008年118-10] Although acute lung injury contributes significantly to critical illness, resolution often occurs spontaneously via activation of incompletely understood pathways. We recently found that mechanical ventilation of mice in... Neural stem cell transplantation can ameliorate the phenotype of a mouse model of spinal muscular atrophy [作者：Corti, S; Nizzardo, M; Nardini, M; Donadoni, C; Salani, S; Ronchi, D; Saladino, F; Bordoni, A; Fortunato, F; Del Bo, R; Papadimitriou, D; Locatelli, F; Menozzi, G; Strazzer, S; Bresolin, N; Comi, GR,期刊：Journal of clinical investigation, 页码：3316-3330 , 文章类型： Article，,卷期：2008年118-10] Spinal muscular atrophy (SMA), a motor neuron disease (MND) and one of the most common genetic causes of infant mortality, currently has no cure. Patients with SMA exhibit muscle weakness and hypotonia. Stem cell transpl... GSK-3 beta in mouse fibroblasts controls wound healing and fibrosis through an endothelin-1-dependent mechanism (Retracted article. See vol. 118, pg. 3812, 2008) [作者：Kapoor, M; Liu, SX; Shi-Wen, X; Huh, K; McCann, M; Denton, CP; Woodgett, JR; Abraham, DJ; Leask, A,期刊：Journal of clinical investigation, 页码：3279-3290 , 文章类型： Article，,卷期：2008年118-10] Glycogen synthase kinase-3 (GSK-3) is a widely expressed and highly conserved serine/threonine protein kinase encoded by 2 genes, GSK3A and GSK3B. GSK-3 is thought to be involved in tissue repair and fibrogenesis, but it... Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated [作者：Yang, SH; Andres, DA; Spielmann, HP; Young, SG; Fong, LG,期刊：Journal of clinical investigation, 页码：3291-3300 , 文章类型： Article，,卷期：2008年118-10] Hutchinson-Gilford progeria syndrome (HGPS), a rare disease that results in what appears to be premature aging, is caused by the production of a mutant form of prelamin A known as progerin. Progerin retains a farnesyl li... Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans [作者：Omenetti, A; Porrello, A; Jung, Y; Yang, L; Popov, Y; Choi, SS; Witek, RP; Alpini, G; Venter, J; Vandongen, HM; Syn, WK; Baroni, GS; Benedetti, A; Schuppan, D; Diehl, AM,期刊：Journal of clinical investigation, 页码：3331-3342 , 文章类型： Article，,卷期：2008年118-10] Epithelial-mesenchymal transitions (EMTs) play an important role in tissue construction during embryogenesis, and evidence suggests that this process may also help to remodel some adult tissues after injury. Activation o... Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis [作者：Chun, HJ; Ali, ZA; Kojima, Y; Kundu, RK; Sheikh, AY; Agrawal, R; Zheng, LX; Leeper, NJ; Pearl, NE; Patterson, AJ; Anderson, JP; Tsao, PS; Lenardo, MJ; Ashley, EA; Quertermous, T,期刊：Journal of clinical investigation, 页码：3343-3354 , 文章类型： Article，,卷期：2008年118-10] Apelin and its cognate G protein-coupled receptor APJ constitute a signaling pathway with a positive inotropic effect on cardiac function and a vasodepressor function in the systemic circulation. The apelin-APJ pathway a... Metabolite profiling of blood from individuals undergoing planned myocardial infarction reveals early markers of myocardial injury [作者：Lewis, GD; Wei, R; Liu, E; Yang, E; Shi, X; Martinovic, M; Farrell, L; Asnani, A; Cyrille, M; Ramanathan, A; Shaham, O; Berriz, G; Lowry, PA; Palacios, IF; Tasan, M; Roth, FP; Min, JY; Baumgartner, C; Keshishian, H; Addona, T; Mootha, VK; Rosenzweig, A; Carr, SA; Fifer, MA; Sabatine, MS; Gerszten, RE,期刊：Journal of clinical investigation, 页码：3503-3512 , 文章类型： Article，,卷期：2008年118-10] Emerging metabolomic tools have created the opportunity to establish metabolic signatures of myocardial injury. We applied a mass spectrometry-based metabolite profiling platform to 36 patients undergoing alcohol septal ... Cotargeting survival signaling pathways in cancer (vol 118 pg 3003, 2008) [作者：Grant, S,期刊：Journal of clinical investigation, 页码：3513-3513 , 文章类型： Correction，,卷期：2008年118-10] Paradox of B cell-targeted therapies [作者：Kurosaki, T,期刊：Journal of clinical investigation, 页码：3260-3263 , 文章类型： Editorial Material，,卷期：2008年118-10] The use of antibodies against the human B cell surface protein CD20 represents the most advanced therapeutic approach among the B cell-depleting armamentarium for the treatment of autoimmune disorders. However, recent ev... Hedgehog signaling in biliary fibrosis [作者：Greenbaum, LE,期刊：Journal of clinical investigation, 页码：3263-3265 , 文章类型： Editorial Material，,卷期：2008年118-10] Congenital and acquired diseases of the biliary tree, or cholangiopathies, represent a significant source of morbidity and mortality in both children and adults. In late stages of the disease, cholangiocytes can no longe... Prenatal maternal diet affects asthma risk in offspring [作者：Miller, RL,期刊：Journal of clinical investigation, 页码：3265-3268 , 文章类型： Editorial Material，,卷期：2008年118-10] Recently, epigenetic-mediated mechanisms - which involve heritable changes in gene expression in the absence of alterations in DNA sequences - have been proposed as contributing to asthma. In this issue of the JCI, Holli... Novel epitope begets a novel pathway in type 1 diabetes progression [作者：Frellinger, JA,期刊：Journal of clinical investigation, 页码：3268-3271 , 文章类型： Editorial Material，,卷期：2008年118-10] While CD8(+) T cells are critical to diabetogenesis in NOD mice, evidence of their involvement in human type 1 diabetes (T1D) has been circumstantial. The existence of CD8(+) T cells specific for beta cell peptides has b... Coaxing the liver into preventing autoimmune disease in the brain [作者：Hoffman, BE; Herzog, RW,期刊：Journal of clinical investigation, 页码：3271-3273 , 文章类型： Editorial Material，,卷期：2008年118-10] The liver has several unique immunological properties that affect T cell activation and immune regulation. Recent studies have uncovered opportunities for the treatment of genetic disease by directing expression of the f... Toward a broadly protective influenza vaccine [作者：Doherty, PC; Kelso, A,期刊：Journal of clinical investigation, 页码：3273-3275 , 文章类型： Editorial Material，,卷期：2008年118-10] The current inactivated influenza virus vaccines induce antibodies that protect against closely related virus strains. They do not, however, protect against antibody-escape variants of seasonal influenza A viruses or new... Tracing the molecular pathogenesis of antiphospholipid syndrome [作者：Weiler, H,期刊：Journal of clinical investigation, 页码：3276-3278 , 文章类型： Editorial Material，,卷期：2008年118-10] Fetal loss induced by antiphospholipid antibodies (aPLs) in mice is a complement-driven inflammatory condition. Engagement of the complement receptor C5aR on neutrophils induces expression of the principal initiator of t... Molecular processes that handle - and mishandle - dietary lipids [作者：Williams, KJ,期刊：Journal of clinical investigation, 页码：3247-3259 , 文章类型： Review，,卷期：2008年118-10] Overconsumption of lipid-rich diets, in conjunction with physical inactivity, disables and kills staggering numbers of people worldwide. Recent advances in our molecular understanding of cholesterol and triglyceride tran...