- Blockade of Endocannabinoid Hydrolytic Enzymes Attenuates Precipitated Opioid Withdrawal Symptoms in Mice
[作者:Ramesh, D; Ross, GR; Schlosburg, JE; Owens, RA; Abdullah, RA; Kinsey, SG; Long, JZ; Nomura, DK; Sim-Selley, LJ; Cravatt, BF; Akbarali, HI; Lichtman, AH,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:173-185 , 文章类型: Article,,卷期:2011年339-1]
- Delta(9)-Tetrahydrocannbinol (THC), the primary active constituent of Cannabis sativa, has long been known to reduce opioid withdrawal symptoms. Although THC produces most of its pharmacological actions through the activ...
- Anatomically Selective Serotonergic Type 1A and Serotonergic Type 2A Therapies for Parkinson's Disease: An Approach to Reducing Dyskinesia without Exacerbating Parkinsonism?
[作者:Huot, P; Fox, SH; Newman-Tancredi, A; Brotchie, JM,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:2-8 , 文章类型: Article,,卷期:2011年339-1]
- L-DOPA remains the most effective treatment for Parkinson's disease (PD). However, long-term administration of L-DOPA is compromised by complications, particularly dyskinesia. Serotonergic type 1A (5-HT(1A)) receptor ago...
- Glucocorticoids Improve Renal Responsiveness to Atrial Natriuretic Peptide by Up-Regulating Natriuretic Peptide Receptor-A Expression in the Renal Inner Medullary Collecting Duct in Decompensated Heart Failure
[作者:Liu, C; Chen, Y; Kang, YX; Ni, ZH; Xiu, HM; Guan, J; Liu, KS,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:203-209 , 文章类型: Article,,卷期:2011年339-1]
- In heart failure, the renal responsiveness to exogenous and endogenous atrial natriuretic peptide (ANP) is blunted. The mechanisms of renal hyporesponsiveness to ANP are complex, but one potential mechanism is decreased ...
- Signaling in H(2)O(2)-Induced Increase in Cell Proliferation in Barrett's Esophageal Adenocarcinoma Cells
[作者:Zhou, XX; Li, D; Resnick, MB; Behar, J; Wands, J; Cao, WBA,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:218-227 , 文章类型: Article,,卷期:2011年339-1]
- Mechanisms whereby acid reflux may accelerate the progression from Barrett's esophagus (BE) to esophageal adenocarcinoma (EA) are not fully understood. We have previously shown that NADPH oxidase NOX5-S generates reactiv...
- TAK-875, an Orally Available G Protein-Coupled Receptor 40/Free Fatty Acid Receptor 1 Agonist, Enhances Glucose-Dependent Insulin Secretion and Improves Both Postprandial and Fasting Hyperglycemia in Type 2 Diabetic Rats
[作者:Tsujihata, Y; Ito, R; Suzuki, M; Harada, A; Negoro, N; Yasuma, T; Momose, Y; Takeuchi, K,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:228-237 , 文章类型: Article,,卷期:2011年339-1]
- G protein-coupled receptor 40/free fatty acid receptor 1 (GPR40/FFA(1)) is highly expressed in pancreatic beta cells and mediates free fatty acid-induced insulin secretion. This study examined the pharmacological effects...
- Caffeic Acid 3,4-Dihydroxy-Phenethyl Ester Induces Cancer Cell Senescence by Suppressing Twist Expression
[作者:Dong, AL; Fang, YZ; Zhang, L; Xie, J; Wu, X; Zhang, LP; Lian, XY; Chen, YH; Luo, J; Liu, MY,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:238-247 , 文章类型: Article,,卷期:2011年339-1]
- Compared with traditional cytotoxic cancer therapy, therapy-induced cancer cell senescence attracts much interest because it is similarly effective, has fewer side effects, and is more efficiently cleared by immune cells...
- Regulation of Ingestive Behaviors in the Rat by GSK1521498, a Novel mu-Opioid Receptor-Selective Inverse Agonist
[作者:Ignar, DM; Goetz, AS; Noble, KN; Carballo, LH; Stroup, AE; Fisher, JC; Boucheron, JA; Brainard, TA; Larkin, AL; Epperly, AH; Shearer, TW; Sorensen, SD; Speake, JD; Hommel, JD,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:24-34 , 文章类型: Article,,卷期:2011年339-1]
- mu-Opioid receptor (MOR) agonism induces palatable food consumption principally through modulation of the rewarding properties of food. N-{[3,5-difluoro-3'-(1H-1,2,4-triazol-3-yl)-4-biphenylyl]methyl}-2,3-dihydro-1H-inde...
- Nonsteroidal Anti-Inflammatory Drug Flufenamic Acid Is a Potent Activator of AMP-Activated Protein Kinase
[作者:Chi, Y; Li, K; Yan, QJ; Koizumi, S; Shi, LY; Takahashi, S; Zhu, Y; Matsue, H; Takeda, M; Kitamura, M; Yao, J,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:257-266 , 文章类型: Article,,卷期:2011年339-1]
- Flufenamic acid (FFA) is a nonsteroidal anti-inflammatory drug (NSAID). It has anti-inflammatory and antipyretic properties. In addition, it modulates multiple channel activities. The mechanisms underlying the pharmacolo...
- Enhanced Hemeoxygenase Activity in the Rostral Ventrolateral Medulla Mediates Exaggerated Hemin-Evoked Hypotension in the Spontaneously Hypertensive Rat
[作者:Nassar, NN; Li, GC; Strat, AL; Abdel-Rahman, AA,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:267-274 , 文章类型: Article,,卷期:2011年339-1]
- In anesthetized normotensive rats, activation of brainstem hemeoxygenase (HO) elicits sympathoinhibition and hypotension. Accordingly, we tested the hypothesis that attenuated basal or induced HO activity in the rostral ...
- Serotonin Transporter Occupancy in Rats Exposed to Serotonin Reuptake Inhibitors In Utero or via Breast Milk
[作者:Capello, CF; Bourke, CH; Ritchie, JC; Stowe, ZN; Newport, DJ; Nemeroff, A; Owens, MJ,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:275-285 , 文章类型: Article,,卷期:2011年339-1]
- Rigorous data regarding fetal central nervous system (CNS) exposure after antidepressant exposure are sparse. The magnitude of serotonin reuptake inhibitor (SRI) CNS exposure was measured in three groups of rats using ex...
- Novel N-1,2-Dihydroxypropyl Analogs of Lobelane Inhibit Vesicular Monoamine Transporter-2 Function and Methamphetamine-Evoked Dopamine Release
[作者:Horton, DB; Siripurapu, KB; Zheng, GR; Crooks, PA; Dwoskin, LP,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:286-297 , 文章类型: Article,,卷期:2011年339-1]
- Lobelane, a chemically defunctionalized saturated analog of lobeline, has increased selectivity for the vesicular monoamine transporter 2 (VMAT2) compared with the parent compound. Lobelane inhibits methamphetamine-evoke...
- Copper Deficiency Exacerbates Bile Duct Ligation-Induced Liver Injury and Fibrosis in Rats
[作者:Song, M; Zhou, ZX; Chen, T; Zhang, JW; McClain, CJ,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:298-306 , 文章类型: Article,,卷期:2011年339-1]
- Copper levels are elevated in a variety of liver fibrosis conditions. Lowering copper to a certain level protects against fibrosis. However, whether severe copper deficiency is protective against liver fibrosis is not kn...
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