- Involvement of Substance P in Peripheral Neuropathy Induced by Paclitaxel but Not Oxaliplatin
[作者:Tatsushima, Y; Egashira, N; Kawashiri, T; Mihara, Y; Yano, T; Mishima, K; Oishi, R,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:226-235 , 文章类型: Article,,卷期:2011年337-1]
- The painful peripheral neuropathy occurring frequently during chemotherapy with paclitaxel or oxaliplatin is one of their dose-limiting factors. We reported previously that substance P is involved in the pathogenesis of ...
- Pharmacology of GPR55 in Yeast and Identification of GSK494581A as a Mixed-Activity Glycine Transporter Subtype 1 Inhibitor and GPR55 Agonist
[作者:Brown, AJ; Daniels, DA; Kassim, M; Brown, S; Haslam, CP; Terrell, VR; Brown, J; Nichols, PL; Staton, PC; Wise, A; Dowell, SJ,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:236-246 , 文章类型: Article,,卷期:2011年337-1]
- GPR55 is a G protein-coupled receptor activated by L-alpha-lysophosphatidylinositol and suggested to have roles in pain signaling, bone morphogenesis, and possibly in vascular endothelial cells. It has affinity for certa...
- Microinjection of Glycine into the Hypothalamic Paraventricular Nucleus Produces Diuresis, Natriuresis, and Inhibition of Central Sympathetic Outflow
[作者:Krowicki, ZK; Kapusta, DR,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:247-255 , 文章类型: Article,,卷期:2011年337-1]
- Strychnine-sensitive glycine receptors and glycine-immunoreactive fibers are expressed in the hypothalamic paraventricular nucleus (PVN), yet the functional significance of this innervation is unclear. Therefore, these s...
- Pharmacological Characterization of a Novel alpha(2C)-Adrenoceptor Agonist N-[3,4-dihydro-4-(1H-imidazol-4-ylmethyl)-2H-1, 4-benzoxazin-6-yl]-N-ethyl-N '-methylurea (Compound A)
[作者:Corboz, MR; Rivelli, MA; McCormick, KD; Wan, YT; Shah, H; Umland, S; Lieber, G; Jia, YL; McLeod, RL; Morgan, C; Varty, GB; Wu, J; Feng, KI; Boyce, CW; Aslanian, RG; Palamanda, J; Nomeir, AA; Korfmacher, W; Hunter, JC; Anthes, JC; Hey, JA,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:256-266 , 文章类型: Article,,卷期:2011年337-1]
- We define the pharmacological and pharmacokinetic profiles of a novel alpha(2C)-adrenoceptor agonist, compound A [N-[3,4-dihydro-4-(1H-imidazol-4-ylmethyl)-2H-1,4-benzoxazin-6-yl]-N-ethyl-N'-methylurea]. This compound ha...
- Cevimeline-Induced Monophasic Salivation from the Mouse Submandibular Gland: Decreased Na+ Content in Saliva Results from Specific and Early Activation of Na+/H+ Exchange
[作者:Kondo, Y; Nakamoto, T; Mukaibo, T; Kidokoro, M; Masaki, C; Hosokawa, R,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:267-274 , 文章类型: Article,,卷期:2011年337-1]
- Cevimeline and pilocarpine are muscarinic agonists used clinically to treat dry mouth. In this study, we explored fluid secretion from mouse submandibular glands to determine the mechanism of cevimeline, pilocarpine, and...
- Characterization of Highly Efficacious Allosteric Agonists of the Human Calcium-Sensing Receptor
[作者:Ma, JN; Owens, M; Gustafsson, M; Jensen, J; Tabatabaei, A; Schmelzer, K; Olsson, R; Burstein, ES,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:275-284 , 文章类型: Article,,卷期:2011年337-1]
- We discovered structurally novel human calcium-sensing receptor (CaSR) allosteric agonists and compared their pharmacology to phenylalkylamine calcimimetics. 1-Benzothiazol-2-yl-1-(2,4-dimethyl-phenyl)-ethanol (AC-265347...
- BeKm-1, a Peptide Inhibitor of Human ether-a-go-go-Related Gene Potassium Currents, Prolongs QTc Intervals in Isolated Rabbit Heart
[作者:Qu, YS; Fang, M; Gao, BX; Chui, RW; Vargas, HM,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:2-8 , 文章类型: Article,,卷期:2011年337-1]
- Drug-induced cardiac arrhythmia, specifically Torsades de pointes, is associated with QT/QTc interval prolongation, thus prolongation of the QT interval is considered as a biomarker for Torsades de pointes risk (N Engl J...
- Carbon Monoxide Involved in Modulating HCO3- Secretion in Rat Duodenum
[作者:Takasuka, H; Hayashi, S; Koyama, M; Yasuda, M; Aihara, E; Amagase, K; Takeuchi, K,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:293-300 , 文章类型: Article,,卷期:2011年337-1]
- We examined the effect of the tricarbonyl-dichlororuthenium (II) dimer (CORM-2), a carbon monoxide (CO) donor, on duodenal HCO3- secretion in rats and investigated whether endogenous CO produced by heme oxygenase (HO) is...
- Endothelial Endothelin B Receptor-Mediated Prevention of Cerebrovascular Remodeling Is Attenuated in Diabetes Because of Up-Regulation of Smooth Muscle Endothelin Receptors
[作者:Kelly-Cobbs, AI; Harris, AK; Elgebaly, MM; Li, WG; Sachidanandam, K; Portik-Dobos, V; Johnson, M; Ergul, A,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:9-15 , 文章类型: Article,,卷期:2011年337-1]
- Structure and function of the cerebrovasculature is critical for ischemic stroke outcome. We showed that diabetes causes cerebrovascular remodeling by activation of the endothelin A (ETA) receptors. The goal of this stud...
- Tumor Necrosis Factor-alpha Accelerates the Calcification of Human Aortic Valve Interstitial Cells Obtained from Patients with Calcific Aortic Valve Stenosis via the BMP2-Dlx5 Pathway
[作者:Yu, ZQ; Seya, K; Daitoku, K; Motomura, S; Fukuda, I; Furukawa, KI,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:16-23 , 文章类型: Article,,卷期:2011年337-1]
- Calcific aortic valve stenosis (CAS) is the most frequent heart valve disease in the elderly, accompanied by valve calcification. Tumor necrosis factor-alpha (TNF-alpha), a pleiotropic cytokine secreted mainly from macro...
- Synergistic Interaction between the Two Mechanisms of Action of Tapentadol in Analgesia
[作者:Schroder, W; Tzschentke, TM; Terlinden, R; De Vry, J; Jahnel, U; Christoph, T; Tallarida, RJ,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:312-320 , 文章类型: Article,,卷期:2011年337-1]
- The novel centrally acting analgesic tapentadol [(-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol hydrochloride] combines two mechanisms of action, mu-opioid receptor (MOR) agonism and noradrenaline reuptak...
- JTT-130, A Novel Intestine-Specific Inhibitor of Microsomal Triglyceride Transfer Protein, Suppresses Food Intake and Gastric Emptying with the Elevation of Plasma Peptide YY and Glucagon-Like Peptide-1 in a Dietary Fat-Dependent Manner (vol 336, pg 850, 2011)
[作者:Hata, T; Mera, Y; Ishii, Y; Tadaki, H; Tomimoto, D; Kuroki, Y; Ota, T; Kawai, T; Kakutani, M,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:321-322 , 文章类型: Correction,,卷期:2011年337-1]
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- Novel Oligomeric Proanthocyanidin Derivatives Interact with Membrane Androgen Sites and Induce Regression of Hormone-Independent Prostate Cancer
[作者:Kampa, M; Theodoropoulou, K; Mavromati, F; Pelekanou, V; Notas, G; Lagoudaki, ED; Nifli, AP; Morel-Salmi, C; Stathopoulos, EN; Vercauteren, J; Castanas, E,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:24-32 , 文章类型: Article,,卷期:2011年337-1]
- Prostate cancer is the most common malignancy among men in Western societies, and current therapeutic approaches are evolving to manage growth, recurrence, and mortality neoplasia. Membrane androgen receptors (mARs) have...
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