- The Expression Level of Ecto-NTP Diphosphohydrolase1/CD39 Modulates Exocytotic and Ischemic Release of Neurotransmitters in a Cellular Model of Sympathetic Neurons
[作者:Corti, F; Olson, KE; Marcus, AJ; Levi, R,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:524-532 , 文章类型: Article,,卷期:2011年337-2]
- Once released, norepinephrine is removed from cardiac synapses via reuptake into sympathetic nerves, whereas transmitter ATP is catabolized by ecto-NTP diphosphohydrolase 1 (E-NTPDase1)/CD39, an ecto-ATPase. Because ATP ...
- The Selective Sphingosine 1-Phosphate Receptor 1 Agonist Ponesimod Protects against Lymphocyte-Mediated Tissue Inflammation
[作者:Piali, L; Froidevaux, S; Hess, P; Nayler, O; Bolli, MH; Schlosser, E; Kohl, C; Steiner, B; Clozel, M,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:547-556 , 文章类型: Article,,卷期:2011年337-2]
- Lymphocyte exit from lymph nodes and their recirculation into blood is controlled by the sphingolipid sphingosine 1-phosphate (S1P). The cellular receptor mediating lymphocyte exit is S1P(1), one of five S1P receptors. N...
- Awake Rat Pharmacological Magnetic Resonance Imaging as a Translational Pharmacodynamic Biomarker: Metabotropic Glutamate 2/3 Agonist Modulation of Ketamine-Induced Blood Oxygenation Level Dependence Signals (vol 336, pg 709, 2011)
[作者:Chin, CL; Upadhyay, J; Marek, GJ; Baker, SJ; Zhang, M; Mezler, M; Fox, GB; Day, M,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:567-567 , 文章类型: Correction,,卷期:2011年337-2]
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- Physiologically Based Pharmacokinetic Modeling to Predict Transporter-Mediated Clearance and Distribution of Pravastatin in Humans (vol 328, pg 652, 2009)
[作者:Watanabe, T; Kusuhara, H; Maeda, K; Shitara, Y; Sugiyama, Y,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:568-569 , 文章类型: Correction,,卷期:2011年337-2]
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- Phosphatidylinositol 3-Kinase Isoform-Specific Effects in Airway Mesenchymal Cell Function
[作者:Moir, LM; Trian, T; Ge, Q; Shepherd, PR; Burgess, JK; Oliver, BGG; Black, JL,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:557-566 , 文章类型: Article,,卷期:2011年337-2]
- The phosphatidylinositol 3-kinase (PI3K) signal transduction pathway is implicated in the airway remodeling associated with asthma. The class IA PI3K isoforms are known to be activated by growth factors and cytokines. Be...
- Beneficial Effect of Glatiramer Acetate Treatment on Syndecan-1 Expression in Dextran Sodium Sulfate Colitis
[作者:Yablecovitch, D; Shabat-Simon, M; Aharoni, R; Eilam, R; Brenner, O; Arnon, R,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:391-399 , 文章类型: Article,,卷期:2011年337-2]
- Syndecan-1, the most abundant heparan sulfate proteoglycan in the gastrointestinal tract, is reduced in the regenerative epithelium in inflammatory bowel disease (IBD). This study explored the effects of the immunomodula...
- Structure-Activity Relationship of Capsaicin Analogs and Transient Receptor Potential Vanilloid 1-Mediated Human Lung Epithelial Cell Toxicity
[作者:Thomas, KC; Ethirajan, M; Shahrokh, K; Sun, H; Lee, J; Cheatham, TE; Yost, GS; Reilly, CA,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:400-410 , 文章类型: Article,,卷期:2011年337-2]
- Activation of intracellular transient receptor potential vanilloid-1 (TRPV1) in human lung cells causes endoplasmic reticulum (ER) stress, increased expression of proapoptotic GADD153 (growth arrest-and DNA damage-induci...
- Single Application of Low-Dose Mycophenolate Mofetil-OX7-Immunoliposomes Ameliorates Experimental Mesangial Proliferative Glomerulonephritis
[作者:Suana, AJ; Tuffin, G; Frey, BM; Knudsen, L; Muhlfeld, C; Rodder, S; Marti, HP,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:411-422 , 文章类型: Article,,卷期:2011年337-2]
- IgA nephropathy, one of the most frequent forms of glomerulonephritis, characterized by mesangial hypercellularity and glomerular extracellular matrix (ECM) expansion, often leads to end-stage renal disease over a prolon...
- S-Adenosylmethionine Decreases Lipopolysaccharide-Induced Phosphodiesterase 4B2 and Attenuates Tumor Necrosis Factor Expression via cAMP/Protein Kinase A Pathway
[作者:Gobejishvili, L; Avila, DV; Barker, DF; Ghare, S; Henderson, D; Brock, GN; Kirpich, IA; Joshi-Barve, S; Mokshagundam, PL; McClain, CJ; Barve, S,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:433-443 , 文章类型: Article,,卷期:2011年337-2]
- S-Adenosylmethionine (SAM) treatment has anti-inflammatory, cytoprotective effects against endotoxin-induced organ injury. An important component of the anti-inflammatory action of SAM involves down-regulation of the lip...
- 2 '-AMP and 3 '-AMP Inhibit Proliferation of Preglomerular Vascular Smooth Muscle Cells and Glomerular Mesangial Cells via A(2B) Receptors
[作者:Jackson, EK; Gillespie, DG; Dubey, RK,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:444-450 , 文章类型: Article,,卷期:2011年337-2]
- Studies show that kidneys produce 2',3'-cAMP, 2',3'-cAMP is exported and metabolized to 2'-AMP and 3'-AMP, 2'-AMP and 3'-AMP are metabolized to adenosine, 2',3'-cAMP inhibits proliferation of preglomerular vascular smoot...
- Growth Arrest-Specific Protein 6 Receptor Antagonism Impairs Adipocyte Differentiation and Adipose Tissue Development in Mice
[作者:Lijnen, HR; Christiaens, V; Scroyen, I,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:457-464 , 文章类型: Article,,卷期:2011年337-2]
- A low-molecular-weight receptor tyrosine kinase inhibitor, 1-(6,7-dihydro-5H-benzo(6,7)cyclohepta(1,2-c)pyridazin-3-yl)-N3-((7-pyrrolidin-1-yl)-6,7,8,9-tetrahydro-5H-benzo(7)annulene-2-yl)-1H-1,2,4-triazole-3,5-diamine (...
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