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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共9条记录   A Hydrazide Linker Strategy for Heterobivalent Compounds as Ortho- and Allosteric Ligands of Acetylcholine-Binding Proteins [作者：Elsinghorst, PW; Hartig, W; Gundisch, D; Mohr, K; Trankle, C; Gutschow, M,期刊：Current Topics in Medicinal Chemistry, 页码：2731-2748 , 文章类型： Review，,卷期：2011年11-22] The occurrence of orthosteric and allosteric binding sites is a characteristic common feature of several acetylcholine-binding proteins, like acetylcholinesterase or the nicotinic and muscarinic acetylcholine receptors. ... Epigenetic Multiple Modulators [作者：Alvarez, R; Altucci, L; Gronemeyer, H; de Lera, AR,期刊：Current Topics in Medicinal Chemistry, 页码：2749-2787 , 文章类型： Review，,卷期：2011年11-22] The development of ligands that as single chemical entities are able to modulate multiple epigenetic targets simultaneously (designed epigenetic multiple ligands) is still in its infancy. We are witnessing some advances ... Lights and Shadows on Monoamine Oxidase Inhibition in Neuroprotective Pharmacological Therapies [作者：Binda, C; Milczek, EM; Bonivento, D; Wang, J; Mattevi, A; Edmondson, DE,期刊：Current Topics in Medicinal Chemistry, 页码：2788-2796 , 文章类型： Review，,卷期：2011年11-22] Playing a pivotal role in the metabolism of neurotransmitters in the central nervous system, the mitochondrial enzymes monoamine oxidases A and B (MAO A and B) have been for long studied as drug targets for neurodegenera... Multitarget-Directed Ligands: Innovative Chemical Probes and Therapeutic Tools Against Alzheimer's Disease [作者：Bolognesi, ML; Simoni, E; Rosini, M; Minarini, A; Tumiatti, V; Melchiorre, C,期刊：Current Topics in Medicinal Chemistry, 页码：2797-2806 , 文章类型： Review，,卷期：2011年11-22] Multitarget agents directed at selected molecular targets involved in the pathogenic cascade of Alzheimer's disease (AD) have been increasingly sought after in recent years, with the aim of achieving enhanced therapeutic... 1,8-Naphthyridine Derivatives as Cholinesterases Inhibitors and Cell Ca2+ Regulators, a Multitarget Strategy for Alzheimer's Disease [作者：Egea, J; de los Rios, C,期刊：Current Topics in Medicinal Chemistry, 页码：2807-2823 , 文章类型： Review，,卷期：2011年11-22] The synthesis and the pharmacological evaluation of 1,8-naphthyridine derivatives and related compounds as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), as well as voltage-dependant Ca2+ ch... Multi-Target-Directed Ligands as Innovative Tools to Combat Trypanosomatid Diseases [作者：Bolognesi, ML,期刊：Current Topics in Medicinal Chemistry, 页码：2824-2833 , 文章类型： Review，,卷期：2011年11-22] Of the tropical diseases, trypanosomiases and leishmaniases should most concern the pharmaceutical community because of their high prevalence in developing countries and the lack of effective drug treatments. Despite thi... Multitarget Antithrombotic Drugs [作者：Ilic, M; Kikelj, D; Ilas, J,期刊：Current Topics in Medicinal Chemistry, 页码：2834-2848 , 文章类型： Review，,卷期：2011年11-22] Thromboembolic disorders are still the leading causes of morbidity and mortality in developed societies. Therefore, prophylaxis and treatment of arterial and venous thrombosis are among the main therapeutic challenges no... The Medicinal Chemistry of Hybrid-Based Drugs Targeting Multiple Sites of Action [作者：Marco-Contelles, J; Soriano, E,期刊：Current Topics in Medicinal Chemistry, 页码：2714-2715 , 文章类型： Editorial Material，,卷期：2011年11-22] Hybrid-Based Multi-Target Ligands for the Treatment of Alzheimer's Disease [作者：Rampa, A; Belluti, F; Gobbi, S; Bisi, A,期刊：Current Topics in Medicinal Chemistry, 页码：2716-2730 , 文章类型： Review，,卷期：2011年11-22] Progresses in medicinal chemistry over the last few years have focused on the design and synthesis of hybrid compounds, molecules encompassing in a single scaffold two pharmacophores from known entities endowed with well...