个性化文献订阅>文章检索

文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共9条记录   The Significance of Chirality in Drug Design and Development [作者：Brooks, WH; Guida, WC; Daniel, KG,期刊：Current Topics in Medicinal Chemistry, 页码：760-770 , 文章类型： Review，,卷期：2011年11-7] Proteins are often enantioselective towards their binding partners. When designing small molecules to interact with these targets, one should consider stereoselectivity. As considerations for exploring structure space ev... Numerical Descriptors for the Characterization of Chiral Compounds and their Applications in Modeling Biological and Toxicological Activities [作者：Natarajan, R; Basak, SC,期刊：Current Topics in Medicinal Chemistry, 页码：771-787 , 文章类型： Review，,卷期：2011年11-7] Due to the advancement in chiral synthesis and separation technology and the new regulatory policies for chiral pharmaceuticals several manufacturers are replacing the previously marketed racemate chemicals with single e... Selectivity Filters to Edit Out Deleterious Side Effects in Kinase Inhibitors [作者：Sessel, S; Fernandez, A,期刊：Current Topics in Medicinal Chemistry, 页码：788-799 , 文章类型： Review，,卷期：2011年11-7] As the molecular etiology of cancer unravels, revealing the heterogeneous nature of the malignancy, multi-target drug treatments are more frequently advocated. Such therapeutic avenues often target kinases, the basic sig... Chiral Kinase Inhibitors [作者：Jiang, JK; Shen, M; Thomas, CJ; Boxer, MB,期刊：Current Topics in Medicinal Chemistry, 页码：800-809 , 文章类型： Review，,卷期：2011年11-7] Small molecule kinase inhibitors are important tools for studying cellular signaling pathways, phenotypes and are, occasionally, useful clinical agents. With stereochemistry pervasive throughout the molecules of life it ... Stereochemistry at the Forefront in the Design and Discovery of Novel Anti-tuberculosis Agents [作者：Huang, QQ; He, R; Kozikowski, AP,期刊：Current Topics in Medicinal Chemistry, 页码：810-818 , 文章类型： Review，,卷期：2011年11-7] Today, 75% of new drugs introduced to the market are single enantiomers and new techniques in asymmetric synthesis and chiral separation expedites chiral drug discovery and development worldwide. The enantiomers of a chi... Structural Insight Into the Crucial Role of Ligand Chirality in the Activation of PPARs by Crystallographic Methods [作者：Loiodice, F; Pochetti, G,期刊：Current Topics in Medicinal Chemistry, 页码：819-839 , 文章类型： Review，,卷期：2011年11-7] Peroxisome Proliferator-Activated Receptors (PPARs) are ligand-activated transcription factors that govern lipid and glucose homeostasis playing a central role in cardiovascular disease, obesity, and diabetes. These rece... The Importance of Stereochemistry on the Actions of Vitamin D [作者：Chiellini, G; DeLuca, HF,期刊：Current Topics in Medicinal Chemistry, 页码：840-859 , 文章类型： Review，,卷期：2011年11-7] The seco-steroid hormone 1 alpha,25-dihydroxyvitamin D-3 [1 alpha,25(OH)(2)D-3] is the most potent natural metabolite of vitamin D-3 and regulates primarily calcium and phosphate homeostasis, but also as a regulator of s... Structural Requirements to Obtain Highly Potent and Selective 18 kDa Translocator Protein (TSPO) Ligands [作者：Taliani, S; Pugliesi, I; Da Settimo, F,期刊：Current Topics in Medicinal Chemistry, 页码：860-886 , 文章类型： Review，,卷期：2011年11-7] The (18 kDa) Translocator Protein (TSPO) was initially identified in 1977 as peripheral binding site for the benzodiazepine diazepam and named "Peripheral-type benzodiazepine receptor (PBR)". It is an evolutionarily well... Glutamate Receptor Agonists: Stereochemical Aspects [作者：Vogensen, SB; Greenwood, JR; Bunch, L; Clausen, RP,期刊：Current Topics in Medicinal Chemistry, 页码：887-906 , 文章类型： Review，,卷期：2011年11-7] The neurotransmitter (S)-glutamate [(S)-Glu] is responsible for most of the excitatory neurotransmission in the central nervous system. The effect of (S)-Glu is mediated by both ionotropic and metabotropic receptors. Glu...