- Homozygosity for the Toll-Like Receptor 2 R753Q Single-Nucleotide Polymorphism Is a Risk Factor for Cytomegalovirus Disease After Liver Transplantation
[作者:Kang, SH; Abdel-Massih, RC; Brown, RA; Dierkhising, RA; Kremers, WK; Razonable, RR,期刊:Journal of Infectious Diseases, 页码:639-646 , 文章类型: Article,,卷期:2012年205-4]
- Immunity against cytomegalovirus (CMV) is initiated after its recognition by Toll-like receptor 2 (TLR2). We assessed the association between a single-nucleotide polymorphism (SNP) that impairs TLR2 function and CMV dise...
- Common Polymorphisms in the PKP3-SIGIRR-TMEM16J Gene Region Are Associated With Susceptibility to Tuberculosis
[作者:Horne, DJ; Randhawa, AK; Chau, TTH; Bang, ND; Yen, NTB; Farrar, JJ; Dunstan, SJ; Hawn, TR,期刊:Journal of Infectious Diseases, 页码:586-594 , 文章类型: Article,,卷期:2012年205-4]
- Background. Tuberculosis has been associated with genetic variation in host immunity. We hypothesized that single-nucleotide polymorphisms (SNPs) in SIGIRR, a negative regulator of Toll-like receptor/IL-1R signaling, are...
- Immune Response Following H1N1pdm09 Vaccination: Differences in Antibody Repertoire and Avidity in Young Adults and Elderly Populations Stratified by Age and Gender
[作者:Khurana, S; Verma, N; Talaat, KR; Karron, RA; Golding, H,期刊:Journal of Infectious Diseases, 页码:610-620 , 文章类型: Article,,卷期:2012年205-4]
- Background. The H1N1 2009 influenza (H1N1pdm09) pandemic had unexpected features, including lower morbidity and mortality in elderly populations. Methods. We performed in-depth elucidation of antibody responses generated...
- Reduction of Antimalarial Antibodies by HIV Infection Is Associated With Increased Risk of Plasmodium falciparum Cord Blood Infection
[作者:Naniche, D; Serra-Casas, E; Bardaji, A; Quinto, L; Dobano, C; Sigauque, B; Cistero, P; Chauhan, VS; Chitnis, CE; Alonso, PL; Menendez, C; Mayor, A,期刊:Journal of Infectious Diseases, 页码:568-577 , 文章类型: Article,,卷期:2012年205-4]
- Background. Plasmodium falciparum infection in pregnancy can lead to congenital malaria, which has detrimental health consequences for infants. Human immunodeficiency virus (HIV) might increase cord blood P. falciparum i...
- Conserved MHC Class I-Presented Dengue Virus Epitopes Identified by Immunoproteomics Analysis Are Targets for Cross-Serotype Reactive T-Cell Response
[作者:Testa, JS; Shetty, V; Sinnathamby, G; Nickens, Z; Hafner, J; Kamal, S; Zhang, XC; Jett, M; Philip, R,期刊:Journal of Infectious Diseases, 页码:647-655 , 文章类型: Article,,卷期:2012年205-4]
- Dengue fever and dengue hemorrhagic fever are significant global public health problems, and understanding the overall immune response to infection will contribute to appropriate management of the disease and its potenti...
- Detection of Acute HIV Infection: A Field Evaluation of the Determine (R) HIV-1/2 Ag/Ab Combo Test
[作者:Rosenberg, NE; Kamanga, G; Phiri, S; Nsona, D; Pettifor, A; Rutstein, SE; Kamwendo, D; Hoffman, IF; Keating, M; Brown, LB; Ndalama, B; Fiscus, SA; Congdon, S; Cohen, MS; Miller, WC,期刊:Journal of Infectious Diseases, 页码:528-534 , 文章类型: Article,,卷期:2012年205-4]
- Background. Most human immunodeficiency virus (HIV) point-of-care tests detect antibodies (Ab) but not p24 antigen (Ag) or RNA. In the absence of antibodies, p24 antigen and RNA typically indicate acute HIV infection. We...
- Sequestration and Microvascular Congestion Are Associated With Coma in Human Cerebral Malaria
[作者:Ponsford, MJ; Medana, IM; Prapansilp, P; Hien, TT; Lee, SJ; Dondorp, AM; Esiri, MM; Day, NPJ; White, NJ; Turner, GDH,期刊:Journal of Infectious Diseases, 页码:663-671 , 文章类型: Article,,卷期:2012年205-4]
- The pathogenesis of coma in severe Plasmodium falciparum malaria remains poorly understood. Obstruction of the brain microvasculature because of sequestration of parasitized red blood cells (pRBCs) represents one mechani...
- Does Discordancy Between the CD4 Count and CD4 Percentage in HIV-Positive Individuals Influence Outcomes on Highly Active Antiretroviral Therapy?
[作者:Gompels, M; Dunn, DT; Phillips, A; Dooley, D; Thomas, AD; Anderson, J; Post, F; Pillay, D; Gazzard, B; Hill, T; Johnson, M; Gilson, R; Bansi, L; Easterbrook, P; Fisher, M; Walsh, J; Orkin, C; Ainsworth, J; Leen, C; Sabin, C,期刊:Journal of Infectious Diseases, 页码:540-547 , 文章类型: Article,,卷期:2012年205-4]
- Introduction. The CD4 count and CD4 percentage (CD4%) are both strong predictors of clinical disease progression in human immunodeficiency virus (HIV). Although individuals may show discordancy between their CD4 count an...
- Evaluation of HIV Protease Inhibitor Use and the Risk of Sudden Death or Nonhemorrhagic Stroke
[作者:Worm, SW; Kamara, DA; Reiss, P; Fontas, E; De Wit, S; El-Sadr, W; Monforte, AD; Law, M; Phillips, A; Ryom, L; Dabis, F; Weber, R; Sabin, C; Lundgren, JD,期刊:Journal of Infectious Diseases, 页码:535-539 , 文章类型: Article,,卷期:2012年205-4]
- Concerns have arisen about possible effects of protease inhibitors (PIs) on cardiac conductivity. We found no significant association between current or recent PI exposure and sudden death or nonhemorrhagic stroke (adjus...
- Study of Genotypic and Phenotypic HIV-1 Dynamics of Integrase Mutations During Raltegravir Treatment: A Refined Analysis by Ultra-Deep 454 Pyrosequencing
[作者:Armenia, D; Vandenbroucke, I; Fabeni, L; Van Marck, H; Cento, V; D'Arrigo, R; Van Wesenbeeck, L; Scopelliti, F; Micheli, V; Bruzzone, B; Lo Caputo, S; Aerssens, J; Rizzardini, G; Tozzi, V; Narciso, P; Antinori, A; Stuyver, L; Perno, CF; Ceccherini-Silberstein, F,期刊:Journal of Infectious Diseases, 页码:557-567 , 文章类型: Article,,卷期:2012年205-4]
- Background. The dynamics of raltegravir-resistant variants and their impact on virologic response in 23 HIV-1-infected patients, who started a salvage raltegravir-containing regimen, were investigated. Methods. Integrase...
- Evaluation of ITX 5061, a Scavenger Receptor B1 Antagonist: Resistance Selection and Activity in Combination With Other Hepatitis C Virus Antivirals
[作者:Zhu, HH; Wong-Staal, F; Lee, H; Syder, A; McKelvy, J; Schooley, RT; Wyles, DL,期刊:Journal of Infectious Diseases, 页码:656-662 , 文章类型: Article,,卷期:2012年205-4]
- ITX 5061 is a scavenger receptor B1 antagonist that has entered phase 1 clinical trials in hepatitis C virus (HCV)-infected humans. We evaluated ITX 5061 in combination with interferon-alpha, ribavirin, and HCV protease ...
- Mouse Model of Necrotic Tuberculosis Granulomas Develops Hypoxic Lesions
[作者:Harper, J; Skerry, C; Davis, SL; Tasneen, R; Weir, M; Kramnik, I; Bishai, WR; Pomper, MG; Nuermberger, EL; Jain, SK,期刊:Journal of Infectious Diseases, 页码:595-602 , 文章类型: Article,,卷期:2012年205-4]
- Background. Preclinical evaluation of tuberculosis drugs is generally limited to mice. However, necrosis and hypoxia, key features of human tuberculosis lesions, are lacking in conventional mouse strains. Methods. We use...
- Mycobacterium tuberculosis Promotes Regulatory T-Cell Expansion via Induction of Programmed Death-1 Ligand 1 (PD-L1, CD274) on Dendritic Cells
[作者:Trinath, J; Maddur, MS; Kaveri, SV; Balaji, KN; Bayry, J,期刊:Journal of Infectious Diseases, 页码:694-696 , 文章类型: Letter,,卷期:2012年205-4]
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