- The effects of exosite occupancy on the substrate specificity of thrombin
[作者:Ng, NMY; Quinsey, NS; Matthews, AY; Kaiserman, D; Wijeyewickrema, LC; Bird, PI; Thompson, PE; Pike, RN,期刊:Archives of Biochemistry and Biophysics , 页码:48-54 , 文章类型: Article,,卷期:2009年489-1-2]
- Thrombin (EC 3.4.4.13) has two exosites that mediate interactions between the enzyme and its substrates and cofactors. The binding of ligands to the exosites alters the functions of the protease, for example, when the co...
- Antithrombin III suppresses ADP-induced platelet granule secretion: Inhibition of HSP27 phosphorylation
[作者:Doi, T; Adachi, S; Takai, S; Matsushima-Nishiwaki, R; Kato, H; Enomoto, Y; Minamitani, C; Otsuka, T; Tokuda, H; Akamatsu, S; Iwama, T; Kozawa, O; Ogura, S,期刊:Archives of Biochemistry and Biophysics , 页码:62-67 , 文章类型: Article,,卷期:2009年489-1-2]
- Antithrombin III (AT-III), an anti-coagulant, has recently been reported to directly affect human platelet functions. However, the exact mechanism of AT-III in platelets remains to be clarified. We have previously shown ...
- Effects of urea and acetic acid on the heme axial ligation structure of ferric myoglobin at very acidic pH
[作者:Droghetti, E; Sumithran, S; Sono, M; Antalik, M; Fedurco, M; Dawson, JH; Smulevich, G,期刊:Archives of Biochemistry and Biophysics , 页码:68-75 , 文章类型: Article,,卷期:2009年489-1-2]
- The heme iron coordination of ferric myoglobin (Mb) in the presence of 9.0 M urea and 8.0 M acetic acid at acidic pH values has been probed by electronic absorption, magnetic circular dichroism and resonance Raman spectr...
- The arachidonic acid epoxygenase is a component of the signaling mechanisms responsible for VEGF-stimulated angiogenesis
[作者:Yang, SL; Wei, SZ; Pozzi, A; Capdevila, JH,期刊:Archives of Biochemistry and Biophysics , 页码:82-91 , 文章类型: Article,,卷期:2009年489-1-2]
- Cultured lung endothelial cells (LEC) respond to VEGF or arachidonic acid with increases in cell proliferation, the formation of tube-like structures, and the activation of Akt and ERK1/2 mediated growth pathways. LECs e...
- Catalytically-inactive beta-amylase BAM4 required for starch breakdown in Arabidopsis leaves is a starch-binding-protein
[作者:Li, J; Francisco, P; Zhou, WX; Edner, C; Steup, M; Ritte, G; Bond, CS; Smith, SM,期刊:Archives of Biochemistry and Biophysics , 页码:92-98 , 文章类型: Article,,卷期:2009年489-1-2]
- Of the four chloroplast beta-amylase (BAM) proteins identified in Arabidopsis, BAM3 and BAM4 were previously shown to play the major roles in leaf starch breakdown, although BAM4 apparently lacks key active site residues...
- The effect of the dilated cardiomyopathy-causing mutation Glu54Lys of alpha-tropomyosin on actin-myosin interactions during the ATPase cycle
[作者:Borovikov, YS; Karpicheva, OE; Avrova, SV; Robinson, P; Redwood, CS,期刊:Archives of Biochemistry and Biophysics , 页码:20-24 , 文章类型: Article,,卷期:2009年489-1-2]
- In order to understand how the Glu54Lys mutation of alpha-tropomyosin affects actomyosin interactions, we labeled SH1 helix of myosin subfragment-1 (S1) and the actin subdomain-1 with fluorescent probes. These proteins w...
- Interaction of nitric oxide with the activity of cytosolic NADH/cytochrome c electron transport system
[作者:Laraspata, D; Gorgoglione, V; La Piana, G; Palmitessa, V; Marzulli, D; Lofrumento, NE,期刊:Archives of Biochemistry and Biophysics , 页码:99-109 , 文章类型: Article,,卷期:2009年489-1-2]
- Nitric oxide ((NO)-N-center dot) generated by the dissociation of S-nitrosoglutathione or added as gaseous solution, inhibits the oxidation of exogenous NADH supported by the activity of the cytosolic NADH/cyto-c electro...
|