- miR-107 Regulates Granulin/Progranulin with Implications for Traumatic Brain Injury and Neurodegenerative Disease
[作者:Wang, WX; Wilfred, BR; Madathil, SK; Tang, GL; Hu, YL; Dimayuga, J; Stromberg, AJ; Huang, QW; Saatman, KE; Nelson, PT,期刊:American Journal of Pathology, 页码:334-345 , 文章类型: Article,,卷期:2010年177-1]
- Granulin (GRN, or progranulin) is a protein involved in wound repair, inflammation, and neoplasia. GRN has also been directly implicated in frontotemporal dementia and may contribute to Alzheimer's disease pathogenesis. ...
- Methamphetamine Increases Brain Viral Load and Activates Natural Killer Cells in Simian Immunodeficiency Virus-Infected Monkeys
[作者:Marcondes, MCG; Flynn, C; Watry, DD; Zandonatti, M; Fox, HS,期刊:American Journal of Pathology, 页码:355-361 , 文章类型: Article,,卷期:2010年177-1]
- Methamphetamine (Meth) abuse increases risky behaviors that contribute to the spread of HIV infection. In addition, because HIV and Meth independently affect physiological systems including the central nervous system, HI...
- Tracheal Basal Cells A Facultative Progenitor Cell Pool
[作者:Cole, BB; Smith, RW; Jenkins, KM; Graham, BB; Reynolds, PR; Reynolds, SD,期刊:American Journal of Pathology, 页码:362-376 , 文章类型: Article,,卷期:2010年177-1]
- Analysis of lineage relationships in the naphthalene-injured tracheal epithelium demonstrated that two multipotential keratin 14-expressing cells (K14ECs) function as progenitors for Clara and ciliated cells. These K14EC...
- Down-Regulation of CD9 Expression and its Correlation to Tumor Progression in B Lymphomas
[作者:Yoon, SO; Zhang, X; Freedman, AS; Zahrieh, D; Lossos, IS; Li, L; Choi, YS,期刊:American Journal of Pathology, 页码:377-386 , 文章类型: Article,,卷期:2010年177-1]
- Histological transformation, a pivotal event in the natural history of cancers including lymphomas, is typically associated with more aggressive clinical behavior. L3055, a B lymphoma cell line of germinal center (GC) or...
- Sonic Hedgehog Acts as a Negative Regulator of beta-Catenin Signaling in the Adult Tongue Epithelium
[作者:Schneider, FT; Schanzer, A; Czupalla, CJ; Thom, S; Engels, K; Schmidt, MHH; Plate, KH; Liebner, S,期刊:American Journal of Pathology, 页码:404-414 , 文章类型: Article,,卷期:2010年177-1]
- Wnt/beta-catenin signaling has been implicated in taste papilla development; however, its role in epithelial maintenance and tumor progression in the adult tongue remains elusive. We show Wnt/beta-catenin pathway activat...
- Selective Cell Death of Hyperploid Neurons in Alzheimer's Disease
[作者:Arendt, T; Bruckner, MK; Mosch, B; Losche, A,期刊:American Journal of Pathology, 页码:15-20 , 文章类型: Article,,卷期:2010年177-1]
- Aneuploidy, an abnormal number of copies of a genomic region, might be a significant source for neuronal complexity, intercellular diversity, and evolution. Genotnic instability associated with aneuploidy,, however, can ...
- miR-182 as a Prognostic Marker for Glioma Progression and Patient Survival
[作者:Jiang, LL; Mao, P; Song, LB; Wu, JH; Huang, JT; Lin, CY; Yuan, J; Qu, LH; Cheng, SY; Li, J,期刊:American Journal of Pathology, 页码:29-38 , 文章类型: Article,,卷期:2010年177-1]
- Accumulating evidence indicates that miRNA expression can be used as a diagnostic and prognostic marker for human cancers. We report that the expression level of miR-182 was markedly up-regulated in glioma cell lines and...
- Epigenetic Regulation of Myofibroblast Differentiation by DNA Methylation
[作者:Hu, B; Gharaee-Kermani, M; Wu, Z; Phan, SH,期刊:American Journal of Pathology, 页码:21-28 , 文章类型: Article,,卷期:2010年177-1]
- DNA methylation, a key mechanism of repressing gene expression, is of particular relevance in controlling development and cell differentiation. We analyzed the extent and regulation of DNA methylation of the a-smooth mus...
- Cardiac-Specific Overexpression of HIF-1 alpha Prevents Deterioration of Glycolytic Pathway and Cardiac Remodeling in Streptozotocin-Induced Diabetic Mice
[作者:Xue, WL; Cai, L; Tan, Y; Thistlethwaite, P; Kang, YJ; Li, XK; Feng, WK,期刊:American Journal of Pathology, 页码:97-105 , 文章类型: Article,,卷期:2010年177-1]
- Defective glycolysis and angiogenesis in the heart of diabetic patients and in experimental diabetic animal models have been reported. The aim of this study was to determine whether overexpression of hypoxia-inducible fa...
- N-Acetylcysteine Suppresses Retinal Detachment in an Experimental Model of Proliferative Vitreoretinopathy
[作者:Lei, H; Velez, G; Cui, J; Samad, A; Maberley, D; Matsubara, J; Kazlauskas, A,期刊:American Journal of Pathology, 页码:132-140 , 文章类型: Article,,卷期:2010年177-1]
- Proliferative vitreoretinopathy (PVR) is a complication that develops in 5% to 10% of patients who undergo surgery to correct a detached retina. The only treatment option for PVR is surgical intervention, which has a lim...
- An Akt- and Fra-1-Dependent Pathway Mediates Platelet-Derived Growth Factor-Induced Expression of Thrombomodulin, a Novel Regulator of Smooth Muscle Cell Migration
[作者:Ramachandran, A; Ranpura, SA; Gong, EM; Mulone, M; Cannon, GM; Adam, RM,期刊:American Journal of Pathology, 页码:119-131 , 文章类型: Article,,卷期:2010年177-1]
- Overdistension of hollow organs evokes pathological changes characterized by smooth muscle remodeling. Mechanical stimuli induce smooth muscle cell (SMC) growth through acute activation of signaling cascades and by incre...
- CFTR Inhibition Provokes an Inflammatory Response Associated with an Imbalance of the Annexin A1 Pathway
[作者:Dalli, J; Rosignoli, G; Hayhoe, RPG; Edelman, A; Perretti, M,期刊:American Journal of Pathology, 页码:176-186 , 文章类型: Article,,卷期:2010年177-1]
- Cystic fibrosis (CF), a disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene, is characterized by chronic bacterial infections and inflammation in the lung. Having previously shown that d...
- N-Acetylcysteine and 15 Deoxy-(Delta 12,) (14)-Prostaglandin J2 Exert a Protective Effect Against Autoimmune Thyroid Destruction in Vivo but Not Against Interleukin-1 alpha/Interferon gamma-induced Inhibitory Effects in Thyrocytes in Vitro
[作者:Poncin, S; Colin, IM; Decallonne, B; Clinckspooor, I; Many, MC; Denef, JF; Gerard, AC,期刊:American Journal of Pathology, 页码:219-228 , 文章类型: Article,,卷期:2010年177-1]
- Reactive oxygen species (ROS) are crucial for thyroid hormonogenesis, and their production is kept under tight control. Oxidative stress (OS) is toxic for thyrocytes in an inflammatory context. In vitro, Th1 pro-inflamma...
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