- Kidney disease associated with plasma cell dyscrasias
[作者：Heher, EC; Goes, NB; Spitzer, TR; Raje, NS; Humphreys, BD; Anderson, KC; Richardson, PG,期刊：Blood, 页码：1397-1404 , 文章类型： Review，,卷期：2010年116-9]
- Plasma cell dyscrasias are frequently encountered malignancies often associated with kidney disease through the production of monoclonal immunoglobulin (Ig). Paraproteins can cause a remarkably diverse set of pathologic ...
- Melphalan and prednisone plus thalidomide or placebo in elderly patients with multiple myeloma
[作者：Waage, A; Gimsing, P; Fayers, P; Abildgaard, N; Ahlberg, L; Bjorkstrand, B; Carlson, K; Dahl, IM; Forsberg, K; Gulbrandsen, N; Haukas, E; Hjertner, O; Hjorth, M; Karlsson, T; Knudsen, LM; Nielsen, JL; Linder, O; Mellqvist, UH; Nesthus, I; Rolke, J; Strandberg, M; Sorbo, JH; Wisloff, F; Juliusson, G; Turesson, I,期刊：Blood, 页码：1405-1412 , 文章类型： Article，,卷期：2010年116-9]
- In this double-blind, placebo-controlled study, 363 patients with untreated multiple myeloma were randomized to receive either melphalan-prednisone and thalidomide (MPT) or melphalan-prednisone and placebo (MP). The dose...
- P-glycoprotein inhibition using valspodar (PSC-833) does not improve outcomes for patients younger than age 60 years with newly diagnosed acute myeloid leukemia: Cancer and Leukemia Group B study 19808
[作者：Kolitz, JE; George, SL; Marcucci, G; Vij, R; Powell, BL; Allen, SL; DeAngelo, DJ; Shea, TC; Stock, W; Baer, MR; Hars, V; Maharry, K; Hoke, E; Vardiman, JW; Bloomfield, CD; Larson, RA,期刊：Blood, 页码：1413-1421 , 文章类型： Article，,卷期：2010年116-9]
- Cancer and Leukemia Group B 19808 (CALGB 19808) is the only randomized trial of a second-generation P-glycoprotein (Pgp) modulator in untreated patients with acute myeloid leukemia (AML) younger than age 60 years. We ran...
- Isolation and characterization of endosteal niche cell populations that regulate hematopoietic stem cells
[作者：Nakamura, Y; Arai, F; Iwasaki, H; Hosokawa, K; Kobayashi, I; Gomei, Y; Matsumoto, Y; Yoshihara, H; Suda, T,期刊：Blood, 页码：1422-1432 , 文章类型： Article，,卷期：2010年116-9]
- The endosteal niche is critical for the maintenance of hematopoietic stem cells (HSCs). However, it consists of a heterogeneous population in terms of differentiation stage and function. In this study, we characterized e...
- The human stem cell hierarchy is defined by a functional dependence on Mcl-1 for self-renewal capacity
[作者：Campbell, CJV; Lee, JB; Levadoux-Martin, M; Wynder, T; Xenocostas, A; Leber, B; Bhatia, M,期刊：Blood, 页码：1433-1442 , 文章类型： Article，,卷期：2010年116-9]
- The molecular basis for the unique proliferative and self-renewal properties that hierarchically distinguish human stem cells from progenitors and terminally differentiated cells remains largely unknown. We report a role...
- PGE(2) transiently enhances DC expression of CCR7 but inhibits the ability of DCs to produce CCL19 and attract naive T cells
[作者：Muthuswamy, R; Mueller-Berghaus, J; Haberkorn, U; Reinhart, TA; Schadendorf, D; Kalinski, P,期刊：Blood, 页码：1454-1459 , 文章类型： Article，,卷期：2010年116-9]
- Prostaglandin E-2 (PGE(2)) is an inflammatory mediator often used to increase CCR7 expression in the dendritic cells (DCs) used as cancer vaccines and to enhance their responsiveness to lymph node-associated chemokines. ...
- PI3K/p110 delta is a novel therapeutic target in multiple myeloma
[作者：Ikeda, H; Hideshima, T; Fulciniti, M; Perrone, G; Miura, N; Yasui, H; Okawa, Y; Kiziltepe, T; Santo, L; Vallet, S; Cristea, D; Calabrese, E; Gorgun, G; Raje, NS; Richardson, P; Munshi, NC; Lannutti, BJ; Puri, KD; Giese, NA; Anderson, KC,期刊：Blood, 页码：1460-1468 , 文章类型： Article，,卷期：2010年116-9]
- In this study, we demonstrate expression and examined the biologic sequelae of PI3K/p110 delta signaling in multiple myeloma (MM). Knockdown of p110 delta by small interfering RNA caused significant inhibition of MM cell...
- KLF4 is a tumor suppressor in B-cell non-Hodgkin lymphoma and in classic Hodgkin lymphoma
[作者：Guan, HF; Xie, LK; Leithauser, F; Flossbach, L; Moller, P; Wirth, T; Ushmorov, A,期刊：Blood, 页码：1469-1478 , 文章类型： Article，,卷期：2010年116-9]
- The transcription factor KLF4 may act both as an oncogene and a tumor suppressor in a tissue-depending manner. In T- and pre-B-cell lymphoma, KLF4 was found to act as tumor suppressor. We found the KLF4 promoter methylat...
- Cytogenetic aberrations and their prognostic value in a series of 330 splenic marginal zone B-cell lymphomas: a multicenter study of the Splenic B-Cell Lymphoma Group
[作者：Salido, M; Baro, C; Oscier, D; Stamatopoulos, K; Dierlamm, J; Matutes, E; Traverse-Glehen, A; Berger, F; Felman, P; Thieblemont, C; Gesk, S; Athanasiadou, A; Davis, Z; Gardiner, A; Milla, F; Ferrer, A; Mollejo, M; Calasanz, MJ; Florensa, L; Espinet, B; Luno, E; Wlodarska, I; Verhoef, G; Garcia-Granero, M; Salar, A; Papadaki, T; Serrano, S; Piris, MA; Sole, F,期刊：Blood, 页码：1479-1488 , 文章类型： Article，,卷期：2010年116-9]
- We conducted a retrospective collaborative study to cytogenetically characterize splenic marginal zone lymphoma (SMZL) and ascertain the prognostic value of chromosomal aberrations. Of 330 cases, 72% displayed an aberran...
- Genomic alterations reveal potential for higher grade transformation in follicular lymphoma and confirm parallel evolution of tumor cell clones
[作者：Eide, MB; Liestol, K; Lingjaerde, OC; Hystad, ME; Kresse, SH; Meza-Zepeda, L; Myklebost, O; Troen, G; Aamot, HV; Holte, H; Smeland, EB; Delabie, J,期刊：Blood, 页码：1489-1497 , 文章类型： Article，,卷期：2010年116-9]
- Our aim was to examine the genetics of clonal evolution in follicular lymphoma (FL) and to identify genetic alterations associated with disease progression. A total of 100 biopsies from 44 patients diagnosed with t(14; 1...
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