- 4-(Pyrazol-4-yl)-pyrimidines as Selective Inhibitors of Cyclin-Dependent Kinase 4/6
[作者:CHO YOUNG SHIN; BORLAND MARIA; BRAIN CHRISTOPHER; CHEN CHRISTINE H T; CHENG HONG; CHOPRA RAJIV; CHUNG KRISTY; GROARKE JAMES; HE GUO; HOU YING; KIM SUNKYU; KOVATS STEVEN; LU YIPIN; OREILLY MARC; SHEN JUNQING; SMITH TROY; TRAKSHEL GARY; VOEGTLE MARKUS; XU MEI; XU MING; SUNG MOO JE,期刊:Journal of Medicinal Chemistry, 页码:7938-7957 , 文章类型: Article,,卷期:2010年53-22]
- Identification and structure-guided optimization of a series of 4-(pyrazol-4-yl)-pyrimidines as selective CDK 4/6 inhibitors is reported herein. Several potency and selectivity determinants were established based on the ...
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