- Identification of the Spiro(oxindole-3,3 '-thiazolidine)-Based Derivatives as Potential p53 Activity Modulators
[作者:GOMEZMONTERREY ISABEL; BERTAMINO ALESSIA; PORTA AMALIA; CAROTENUTO ALFONSO; MUSELLA SIMONA; AQUINO CLAUDIO; GRANATA ILARIA; SALA MARINA; BRANCACCIO DIEGO; PICONE DELIA; ERCOLE CARMINE; STIUSO PAOLA; CAMPIGLIA PIETRO; GRIECO PAOLO; IANELLI PIO; MARESCA BRUNO; NOVELLINO ETTORE,期刊:Journal of Medicinal Chemistry, 页码:8319-8329 , 文章类型: Article,,卷期:2010年53-23]
- Here, we report the design of new analogues of spirooxoindolepyrrolidine nucleus as modulators of p53 activity. Compounds (3R,7aR)-6(4-chlorobenzyl)-1H-spiro[imidazo[1,5-c]thiazole-3,3'-indolin e]-2',5,7(6H,7aH)-trione (...
- Acetic Acid Derivatives of 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxide as a Novel Class of Potent Aldose Reductase Inhibitors
[作者:CHEN XIN; ZHU CHANGJIN; GUO FAN; QIU XIAOWEI; YANG YANCHUN; ZHANG SHUZHEN; HE MINLAN; PARVEEN SHAGUFTA; JING CHAOJUN; LI YAN; MA BING,期刊:Journal of Medicinal Chemistry, 页码:8330-8344 , 文章类型: Article,,卷期:2010年53-23]
- A series of novel benzothiadiazine 1,1-dioxide derivatives were synthesized and tested for their inhibitory activity against aldose reductase. Of these derivatives, 17 compounds, having a substituted N2-benzyl group and ...
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