- Design of Selective, ATP-Competitive Inhibitors of Akt
[作者:FREEMANCOOK KEVIN D; AUTRY CHRISTOPHER; BORZILLO GARY; GORDON DEBORAH; BARBACCITOBIN ELSA; BERNARDO VINCENT; BRIERE DAVID; CLARK TRACEY; CORBETT MATTHEW; JAKUBCZAK JOHN; KAKAR SHEFALI; KNAUTH ELIZABETH; LIPPA BLAISE; LUZZIO MICHAEL J; MANSOUR MAHMOUD; MARTINELLI GARY; MARX MATTHEW; NELSON KENDRA; PANDIT JAYVARDHAN; RAJAMOHAN FRANCIS; ROBINSON SHAUGHNESSY; SUBRAMANYAM CHAKRAPANI; WEI LIUQING; WYTHES MARTIN; MORRIS JOEL,期刊:Journal of Medicinal Chemistry, 页码:4615-4622 , 文章类型: Article,,卷期:2010年53-12]
- This paper describes the design and synthesis of novel, ATP-competitive Akt inhibitors from an elaborated 3-aminopyrrolidine scaffold. Key findings include the discovery of an initial lead that was modestly selective and...
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