- A new structural paradigm in copper resistance in Streptococcus pneumoniae
[作者:FU YUE; TSUI HOCHING TIFFANY; BRUCE KEVIN E; SHAM LOKTO; HIGGINS KHADINE A; LISHER JOHN P; KAZMIERCZAK KRYSTYNA M; MARONEY MICHAEL J; DANN CHARLES E III; WINKLER MALCOLM E; GIEDROC DAVID P,期刊:NATURE CHEMICAL BIOLOGY, 页码:177-183 , 文章类型: Article,,卷期:2013年9-3]
- Copper resistance has emerged as an important virulence determinant of microbial pathogens. In Streptococcus pneumoniae, copper resistance is mediated by the copper-responsive repressor CopY, CupA and the copper-effluxin...
- Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain
[作者:JAMES LINDSEY I; BARSYTELOVEJOY DALIA; ZHONG NAN; KRICHEVSKY LIUBOV; KORBOUKH VICTORIA K; HEROLD J MARTIN; MACNEVIN CHRISTOPHER J; NORRIS JACQUELINE L; SAGUM CARI A; TEMPEL WOLFRAM; MARCON EDYTA; GUO HONGBO; GAO CEN; HUANG XIPING; DUAN SHILI; EMILI ANDREW; GREENBLATT JACK F; KIREEV DMITRI B; JIN JIAN; JANZEN WILLIAM P; BROWN PETER J; BEDFORD MARK T; ARROWSMITH CHERYL H; FRYE STEPHEN V,期刊:NATURE CHEMICAL BIOLOGY, 页码:184-191 , 文章类型: Article,,卷期:2013年9-3]
- We describe the discovery of UNC1215, a potent and selective chemical probe for the methyllysine (Kme) reading function of L3MBTL3, a member of the malignant brain tumor (MBT) family of chromatin-interacting transcriptio...
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