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  • Initiation and execution of lipotoxic ER stress in pancreatic beta-cells
    [作者:Cunha, DA; Hekerman, P; Ladriere, L; Bazarra-Castro, A; Ortis, F; Wakeham, MC; Moore, F; Rasschaert, J; Cardozo, AK; Bellomo, E; Overbergh, L; Mathieu, C; Lupi, R; Hai, T; Herchuelz, A; Marchetti, P; Rutter, GA; Eizirik, DL; Cnop, M,期刊:Journal of cell science, 页码:2308-2318 , 文章类型: Review,,卷期:2008年121-14]
  • Free fatty acids (FFA) cause apoptosis of pancreatic beta-cells and might contribute to beta-cell loss in type 2 diabetes via the induction of endoplasmic reticulum (ER) stress. We studied here the molecular mechanisms i...