- The crystal structure of isopenicillin N synthase with delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-methionine reveals thioether coordination to iron
[作者:Clifton, IJ; Ge, W; Adlington, RM; Baldwin, JE; Rutledge, PJ,期刊:Archives of Biochemistry and Biophysics , 页码:103-107 , 文章类型: Article,,卷期:2011年516-2]
- Isopenicillin N synthase (IPNS) catalyses cyclization of delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-valine (ACV) to isopenicillin N (IPN), the central step in penicillin biosynthesis. Previous studies have shown that IPN...
- Inhibition of human DNA topoisomerase IB by a Cyclometalated Gold III compound: Analysis on the different steps of the enzyme catalytic cycle
[作者:Castelli, S; Vassallo, O; Katkar, P; Che, CM; Sun, RWY; Desideri, A,期刊:Archives of Biochemistry and Biophysics , 页码:108-112 , 文章类型: Article,,卷期:2011年516-2]
- A gold(III) compound (Au(C boolean AND N boolean AND C)(IMe)]CF(3)SO(3) (Gold III) has been reported to have anticancer properties as it is able to reduce topoisomerase IB activity in vitro and suppress tumor growth in n...
- Stimulation of human formyl peptide receptors by calpain inhibitors: Homology modeling of receptors and ligand docking simulation
[作者:Fujita, H; Kato, T; Watanabe, N; Takahashi, T; Kitagawa, S,期刊:Archives of Biochemistry and Biophysics , 页码:121-127 , 文章类型: Article,,卷期:2011年516-2]
- Calpain inhibitors, including peptide aldehydes (N-acetyl-Leu-Leu-Nle-CHO and N-acetyl-Leu-Leu-Met-CHO) and alpha-mercapto-acrylic acid derivatives (PD150606 and PD151746), have been shown to stimulate phagocyte function...
- Topoisomerase II beta associates with Ku70 and PARP-1 during double strand break repair of DNA in neurons
[作者:Mandraju, R; Chekuri, A; Bhaskar, C; Duning, K; Kremerskothen, J; Kondapi, AK,期刊:Archives of Biochemistry and Biophysics , 页码:128-137 , 文章类型: Article,,卷期:2011年516-2]
- In the present study, the activity of Topoisomerase II beta (TopoII beta) is evaluated during peroxide induced double stranded DNA breaks (DSBs) repair in primary neurons. The results showed that the TopoII beta levels w...
- Detection of a functional xenobiotic response element in a widely employed FoxO-responsive reporter construct
[作者:Eckers, A; Sauerbier, E; Anwar-Mohamed, A; Hamann, I; Esser, C; Schroeder, P; El-Kadi, AOS; Klotz, LO,期刊:Archives of Biochemistry and Biophysics , 页码:138-145 , 文章类型: Article,,卷期:2011年516-2]
- FHRE-Luc is a promoter reporter construct that is widely used to assess the activity of FoxO (forkhead box, class O) transcription factors. We here demonstrate that this promoter construct responds to exposure of HepG2 h...
- Lectin-induced activation of plasma membrane NADPH oxidase in cholesterol-depleted human neutrophils
[作者:Gorudko, IV; Mukhortava, AV; Caraher, B; Ren, M; Cherenkevich, SN; Kelly, GM; Timoshenko, AV,期刊:Archives of Biochemistry and Biophysics , 页码:173-181 , 文章类型: Article,,卷期:2011年516-2]
- The gp91phox subunit of flavocytochrome 10558 is the catalytic core of the phagocyte plasma membrane NADPH oxidase. Its activation occurs within lipid rafts and requires translocation of four subunits to flavocytochrome ...
- Structure and catalysis by carbonic anhydrase II: Role of active-site tryptophan 5
[作者:Mikulski, R; Domsic, JF; Ling, G; Tu, CK; Robbins, AH; Silverman, DN; McKenna, R,期刊:Archives of Biochemistry and Biophysics , 页码:97-102 , 文章类型: Article,,卷期:2011年516-2]
- The tryptophan residue Trp5, highly conserved in the a class of carbonic anhydrases including human carbonic anhydrase II (HCA II), is positioned at the entrance of the active site cavity and forms a pi-stacking interact...
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