- Engineering a single-chain Fv antibody to alpha v beta 6 integrin using the specificity-determining loop of a foot-and-mouth disease virus
[作者:Kogelberg, H; Tolner, B; Thomas, GJ; Di Cara, D; Minogue, S; Ramesh, B; Sodha, S; Marsh, D; Lowdell, MW; Meyer, T; Begent, RHJ; Hart, I; Marshall, JF; Chester, K,期刊:Journal of Molecular Biology, 页码:385-401 , 文章类型: Article,,卷期:2008年382-2]
- The alpha v beta 6 integrin is a promising target for cancer therapy. Its expression is up-regulated de novo on many types of carcinoma where it may activate transforming growth factor-beta 1 and transforming growth fact...
- The novel protein complex with SMARCAD1/KIAA1122 binds to the vicinity of TSS
[作者:Okazaki, N; Ikeda, S; Ohara, R; Shimada, K; Yanagawa, T; Nagase, T; Ohara, O; Koga, H,期刊:Journal of Molecular Biology, 页码:257-265 , 文章类型: Article,,卷期:2008年382-2]
- The SMARCAD1/KIAA1122 protein is structurally classified into the SW12/SNF2 superfamily of DNA-dependent ATPases that are catalytic subunits of chromatin-remodeling complexes. Although the importance of other members of ...
- The positive transcription elongation factor b is an essential cofactor for the activation of transcription by myocyte enhancer factor 2
[作者:Nojima, M; Huang, YH; Tyagi, M; Kao, HY; Fujinaga, K,期刊:Journal of Molecular Biology, 页码:275-287 , 文章类型: Article,,卷期:2008年382-2]
- The positive transcription elongation factor b (P-TEFb), composed of cyclin-dependent kinase 9 and cyclin T1, stimulates the elongation of transcription by hyperphosphorylating the C-terminal region of RNA polymerase II....
- Expression profiles and physiological roles of two types of prefoldins from the hyperthermophilic archaeon Thermococcus kodakaraensis
[作者:Danno, A; Fukuda, W; Yoshida, M; Aki, R; Tanaka, T; Kanai, T; Imanaka, T; Fujiwara, S,期刊:Journal of Molecular Biology, 页码:298-311 , 文章类型: Article,,卷期:2008年382-2]
- The hyperthermophilic archaeon Thermococcus kodakaraensis possesses four prefoldin genes encoding two alpha subunits (pfdA and pfdC) and two beta subunits (pfdB and pfdD) of prefoldins on the genome. pfdC and pfdD are un...
- Mechanistic basis of zidovudine hypersusceptibility and lamivudine resistance conferred by the deletion of codon 69 in the HIV-1 reverse transcriptase coding region
[作者:Kisic, M; Mendieta, J; Puertas, MC; Parera, M; Martinez, MA; Martinez-Picado, J; Menendez-Arias, L,期刊:Journal of Molecular Biology, 页码:327-341 , 文章类型: Article,,卷期:2008年382-2]
- Deletions in the beta 3-beta 4 hairpin loop of human immunodeficiency virus type 1 reverse transcriptase (RT) are associated with the emergence of multidrug resistance. Common mutational patterns involve the deletion of ...
- Antagonistic pleiotropy involving promoter sequences in a virus
[作者:Presloid, JB; Ebendick-Corpus, BE; Zarate, S; Novella, IS,期刊:Journal of Molecular Biology, 页码:342-352 , 文章类型: Article,,卷期:2008年382-2]
- Selection of specialist genotypes, that is, populations with limited niche width, promotes the maintenance of diversity. Specialization to a particular environment may have a cost ill other environments, including fitnes...
- Solution structure of the C-terminal nucleoprotein-RNA binding domain of the vesicular stomatitis virus phosphoprotein
[作者:Ribeiro, EA; Favier, A; Gerard, FCA; Leyrat, C; Brutscher, B; Blondel, D; Ruigrok, RWH; Blackledge, M; Jamin, M,期刊:Journal of Molecular Biology, 页码:525-538 , 文章类型: Article,,卷期:2008年382-2]
- Beyond common features in their genome organization and replication mechanisms, the evolutionary relationships among viruses of the Rhabdoviridae family are difficult too decipher because of the great variability in the ...
- Structure and dynamics of the P7 protein from the bacteriophage phi 12
[作者:Eryilmaz, E; Benach, J; Su, M; Seetharaman, J; Dutta, K; Wei, H; Gottlieb, P; Hunt, JF; Ghose, R,期刊:Journal of Molecular Biology, 页码:402-422 , 文章类型: Article,,卷期:2008年382-2]
- Cystoviruses are a class of enveloped double-stranded RNA viruses that use a multiprotein polymerase complex (PX) to replicate and transcribe the viral genome. Although the structures of the polymerase and ATPase compone...
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