- DNA sequences in gal operon override transcription elongation blocks
[作者:Lewis, DEA; Komissarova, N; Le, P; Kashlev, M; Adhya, S,期刊:Journal of Molecular Biology, 页码:843-858 , 文章类型: Article,,卷期:2008年382-4]
- The DNA loop that represses transcription from galactose (gal) promoters is infrequently formed in stationary-phase cells because the concentration of the loop architectural protein HU is significantly low at that state,...
- Crystal structures of the pro-inflammatory cytokine interleukin-23 and its complex with a high-affinity neutralizing antibody
[作者:Beyer, BM; Ingram, R; Ramanathan, L; Reichert, P; Le, HV; Madison, V; Orth, P,期刊:Journal of Molecular Biology, 页码:942-955 , 文章类型: Article,,卷期:2008年382-4]
- Interleukin (IL)-23 is a pro-inflammatory cytokine playing a key role in the pathogenesis of several autoimmune and inflammatory diseases. We have determined the crystal structures of the heterodimeric p19-p40 IL-23 and ...
- Evidence for proton shuffling in a thioredoxin-like protein during catalysis
[作者:Narzi, D; Siu, SWI; Stirnimann, CU; Grimshaw, JPA; Glockshuber, R; Capitani, G; Bockmann, RA,期刊:Journal of Molecular Biology, 页码:978-986 , 文章类型: Article,,卷期:2008年382-4]
- Proteins of the thioredoxin (Trx) superfamily catalyze disulfide-bond formation, reduction and isomerization in substrate proteins both in prokaryotic and in eukaryotic cells. All members of the Trx family with thioldisu...
- Reconstitution and analysis of the multienzyme Escherichia coli RNA degradosome
[作者:Worrall, JAR; Gorna, M; Crump, NT; Phillips, LG; Tuck, AC; Price, AJ; Bavro, VN; Luisi, BF,期刊:Journal of Molecular Biology, 页码:870-883 , 文章类型: Article,,卷期:2008年382-4]
- The Escherichia coli RNA degradosome is a multienzyme assembly that functions in transcript turnover and maturation of structured RNA precursors. We have developed a procedure to reconstitute the RNA degradosome from rec...
- Function of transmembrane domain IX in the Na+/proline transporter PutP
[作者:Raba, M; Baumgartner, T; Hilger, D; Klempahn, K; Hartel, T; Jung, K; Jung, H,期刊:Journal of Molecular Biology, 页码:884-893 , 文章类型: Article,,卷期:2008年382-4]
- Selected residues of transmembrane domain (TM) IX were previously shown to play key roles in ligand binding and transport in members of the Na+/solute symporter family. Using the Na+/proline transporter PutP as a model, ...
- Adaptable molecular interactions guide phosphorylation of the SR protein ASF/SF2 by SRPK1
[作者:Hagopian, JC; Ma, CT; Meade, BR; Albuquerque, CP; Ngo, JCK; Ghosh, G; Jennings, PA; Fu, XD; Adams, JA,期刊:Journal of Molecular Biology, 页码:894-909 , 文章类型: Article,,卷期:2008年382-4]
- The SR (arginine-serine rich) protein ASF/SF2 (also called human alternative splicing factor), an essential splicing factor, contains two functional modules consisting of tandem RNA recognition motifs (RRMs; RRM1-RRM2) a...
- Crystal structure of the complex between the F-ab ' fragment of the cross-neutralizing anti-HIV-1 antibody 2F5 and the F-ab fragment of its anti-idiotypic antibody 3H6
[作者:Bryson, S; Julien, JP; Isenman, DE; Kunert, R; Katinger, H; Pai, EF,期刊:Journal of Molecular Biology, 页码:910-919 , 文章类型: Article,,卷期:2008年382-4]
- The monoclonal antibody 2175 neutralizes a broad range of human immunodeficiency virus-1 isolates via a conserved epitope on the viral glycoprotein gp41. The conformation of the principal epitope is a type I beta-turn ce...
- Molecular basis of recognition of human osteopontin by 23C3, a potential therapeutic antibody for treatment of rheumatoid arthritis
[作者:Du, JM; Hou, S; Zhong, C; Lai, Z; Yang, H; Dai, JX; Zhang, DP; Wang, H; Guo, YJ; Ding, JP,期刊:Journal of Molecular Biology, 页码:835-842 , 文章类型: Article,,卷期:2008年382-4]
- Osteopontin plays an important role in the development and perpetuation of rheumatoid arthritis (RA). Antibodies targeting osteopontin have shown promising therapeutic benefits against this disease. We have previously re...
- Structural and functional insights into O-methyltransferase from Bacillus cereus
[作者:Cho, JH; Park, Y; Ahn, JH; Lim, Y; Rhee, S,期刊:Journal of Molecular Biology, 页码:987-997 , 文章类型: Article,,卷期:2008年382-4]
- The specific substrates, mechanisms, and structures of the bacterial O-methyltransferases (OMTs) are not as well characterized as those of other OMTs. Recent studies have suggested that bacterial OMTs catalyze regiospeci...
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