- The Structure and Unusual Protein Chemistry of Hypoxic Response Protein 1, a Latency Antigen and Highly Expressed Member of the DosR Regulon in Mycobacterium tuberculosis
[作者:Sharpe, ML; Gao, C; Kendall, SL; Baker, EN; Lott, JS,期刊:Journal of Molecular Biology, 页码:822-836 , 文章类型: Article,,卷期:2008年383-4]
- Mycobacterium tuberculosis adapts to cellular stresses such as decreased oxygen concentration, at least in part, by upregulation of the dormancy survival regulon, which is thought to be important for the bacterium's abil...
- Ligand Recognition by ActR, a TetR-Like Regulator of Actinorhodin Export
[作者:Tahlan, K; Yu, Z; Xu, Y; Davidson, AR; Nodwell, JR,期刊:Journal of Molecular Biology, 页码:753-761 , 文章类型: Article,,卷期:2008年383-4]
- TetR-like transcriptional repressors interact with small-molecule ligands to control many facets of prokaryotic biology, including clinical antibiotic resistance. ActR is a TetR-like protein encoded in the biosynthetic g...
- Structural Basis of the Preferential Binding for Globo-Series Glycosphingolipids Displayed by Pseudomonas aeruginosa Lectin I
[作者:Blanchard, B; Nurisso, A; Hollville, E; Tetaud, C; Wiels, J; Pokorna, M; Wimmerova, M; Varrot, A; Imberty, A,期刊:Journal of Molecular Biology, 页码:837-853 , 文章类型: Article,,卷期:2008年383-4]
- The opportunistic pathogen Pseudomonas aeruginosa contains several carbohydrate-binding proteins, among which is the P. aeruginosa lectin I (PA-IL), which displays affinity for alpha-galactosylated glycans. Glycan arrays...
- Kap95p Binding Induces the Switch Loops of RanGDP to Adopt the GTP-Bound Conformation: Implications for Nuclear Import Complex Assembly Dynamics
[作者:Forwood, JK; Lonhienne, TG; Marfori, M; Robin, G; Meng, WN; Guncar, G; Liu, SM; Stewart, M; Carroll, BJ; Kobe, B,期刊:Journal of Molecular Biology, 页码:772-782 , 文章类型: Article,,卷期:2008年383-4]
- The asymmetric distribution of the nucleotide-bound state of Ran across the nuclear envelope is crucial for determining the directionality of nuclear transport. In the nucleus, Ran is primarily in the guanosine T-triphos...
- Crystal Structure of tRNA N-2, N-2-Guanosine Dimethyltransferase Trm1 from Pyrococcus horikoshii
[作者:Ihsanawati; Nishimoto, M; Higashijima, K; Shirouzu, M; Grosjean, H; Bessho, Y; Yokoyama, S,期刊:Journal of Molecular Biology, 页码:871-884 , 文章类型: Article,,卷期:2008年383-4]
- Trm1 catalyzes a two-step reaction, leading to mono- and dimethylation of guanosine at position 26 in most eukaryotic and archaeal tRNAs. We report the crystal structures of Trm1 from Pyrococcus horikoshii liganded with ...
- The Crystal Structure of JNK2 Reveals Conformational Flexibility in the MAP Kinase Insert and Indicates Its Involvement in the Regulation of Catalytic Activity
[作者:Shaw, D; Wang, SM; Villasenor, AG; Tsing, S; Walter, D; Browner, MF; Barnett, J; Kuglstatter, A,期刊:Journal of Molecular Biology, 页码:885-893 , 文章类型: Article,,卷期:2008年383-4]
- c-Jun N-terminal kinase (JNK) 2 is a member of the mitogen-activated protein (MAP) kinase group of signaling proteins. MAP kinases share a common sequence insertion called "MAP kinase insert", which, for ERK2, has been s...
- AKAP149 Binds to HIV-1 Reverse Transcriptase and Is Involved in the Reverse Transcription
[作者:Lemay, J; Maidou-Peindara, P; Cancio, R; Ennifar, E; Coadou, G; Maga, G; Rain, JC; Benarous, R; Liu, LX,期刊:Journal of Molecular Biology, 页码:783-796 , 文章类型: Article,,卷期:2008年383-4]
- Like all retroviruses, human immunodeficiency virus type 1 (HIV-1) undergoes reverse transcription during its replication cycle. The cellular cofactors potentially involved in this process still remain to be identified. ...
- Determination of the Topology of the Hydrophobic Segment of Mammalian Diacylglycerol Kinase Epsilon in a Cell Membrane and Its Relationship to Predictions from Modeling
[作者:Decaffmeyer, M; Shulga, YV; Dicu, AO; Thomas, A; Truant, R; Topham, MK; Brasseur, R; Epand, RM,期刊:Journal of Molecular Biology, 页码:797-809 , 文章类型: Article,,卷期:2008年383-4]
- The epsilon isoform of diacylglycerol kinase (DGK epsilon) is unique among mammalian DGKs in having a segment of hydrophobic amino acids comprising approximately residues 20 to 41. Several algorithms predict this segment...
- Architecture and Flexibility of the Yeast Ndc80 Kinetochore Complex
[作者:Wang, HW; Long, S; Ciferri, C; Westermann, S; Drubin, D; Barnes, G; Nogales, E,期刊:Journal of Molecular Biology, 页码:894-903 , 文章类型: Article,,卷期:2008年383-4]
- Kinetochores mediate microtubule-chromosome attachment and ensure accurate segregation of sister chromatids. The highly conserved Ndc80 kinetochore complex makes direct contacts with the microtubule and is essential for ...
- Stability of Dimer and Domain-Domain Interaction of Arabidopsis Phototropin 1 LOV2
[作者:Nakasone, Y; Eitoku, T; Zikihara, K; Matsuoka, D; Tokutomi, S; Terazima, M,期刊:Journal of Molecular Biology, 页码:904-913 , 文章类型: Article,,卷期:2008年383-4]
- Transient grating signals after photoexcitation of Arabidopsis phototropin 1 light-oxygen-voltage 2 (phot1LOV2) domain without the linker were found to be very sensitive to temperature. In particular, the diffusion signa...
- Localization of the N-Terminus of Minor Coat Protein IIIa in the Adenovirus Capsid
[作者:Martin, CS; Glasgow, JN; Borovjagin, A; Beatty, MS; Kashentseva, EA; Curiel, DT; Marabini, R; Dmitriev, IP,期刊:Journal of Molecular Biology, 页码:923-934 , 文章类型: Article,,卷期:2008年383-4]
- Minor coat protein IIIa is conserved in all adenoviruses (Ads) and is required for correct viral assembly, but its precise function in capsid organization is unknown. The latest Ad capsid model proposes that IIIa is loca...
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