- A Conserved Central Region of Yeast Ada2 Regulates the Histone Acetyltransferase Activity of Gcn5 and Interacts with Phospholipids
[作者:Hoke, SMT; Genereaux, J; Liang, G; Brandl, CJ,期刊:Journal of Molecular Biology, 页码:743-755 , 文章类型: Article,,卷期:2008年384-4]
- The SAGA (Spt-Ada-Gen5 acetyltransferase) complex of Saccharomyces cerevisiae contains more than 20 components that acetylate and deubiquitylate nucleosomal histones. Its acetyltransferase, Gcn5, preferentially acetylate...
- A New Regulatory Mechanism of NF-kappa B Activation by I-kappa B beta in Cancer Cells
[作者:Kim, JM; Voll, RE; Ko, C; Kim, DS; Park, KS; Kim, SY,期刊:Journal of Molecular Biology, 页码:756-765 , 文章类型: Article,,卷期:2008年384-4]
- Transglutaminase 2 (TGase 2) catalyzes covalent isopeptide bond formation between glutamine and lysine residues. Recently, we reported that TGase 2 activates nuclear factor-kappa B (NF-kappa B) by depleting inhibitor of ...
- ArPIKfyve Homomeric and Heteromeric Interactions Scaffold PIKfyve and Sac3 in a Complex to Promote PIKfyve Activity and Functionality
[作者:Sbrissa, D; Ikonomov, OC; Fenner, H; Shisheva, A,期刊:Journal of Molecular Biology, 页码:766-779 , 文章类型: Article,,卷期:2008年384-4]
- PtdIns(3,5)P-2 (with PtdIns indicating phosphatidylinositol) is vital in the differentiation and development of multicellular organisms because knock-out of the PtdIns(3,5)P-2-synthesizing enzyme PIKfyve (phosphoinositid...
- Three-Dimensional Reconstruction of Tarantula Myosin Filaments Suggests How Phosphorylation May Regulate Myosin Activity
[作者:Alamo, L; Wriggers, W; Pinto, A; Bartoli, F; Salazar, L; Zhao, FQ; Craig, R; Padron, R,期刊:Journal of Molecular Biology, 页码:780-797 , 文章类型: Article,,卷期:2008年384-4]
- Muscle contraction involves the interaction of the myosin heads of the thick filaments with actin subunits of the thin filaments. Relaxation occurs when this interaction is blocked by molecular switches on these filament...
- The Impact of O-2 on the Fe-S Cluster Biogenesis Requirements of Escherichia coli FNR
[作者:Mettert, EL; Outten, FW; Wanta, B; Kiley, PJ,期刊:Journal of Molecular Biology, 页码:798-811 , 文章类型: Article,,卷期:2008年384-4]
- In this study, the functions of two established Fe-S cluster biogenesis pathways, Isc (iron-sulfur cluster) and Suf (sulfur mobilization), under aerobic and anaerobic growth conditions were compared by measuring the acti...
- Effect of Xenon Binding to a Hydrophobic Cavity on the Proton Pumping Cycle in Bacteriorhodopsin
[作者:Hayakawa, N; Kasahara, T; Hasegawa, D; Yoshimura, K; Murakami, M; Kouyama, T,期刊:Journal of Molecular Biology, 页码:812-823 , 文章类型: Article,,卷期:2008年384-4]
- To understand the functional role of apolar cavities in bacteriorhodopsin, a light-driven proton pump found in Halobacterium salinarum, we investigated the crystal structure in pressurized xenon or krypton. Diffraction d...
- The Crystal Structure of Enamidase: A Bifunctional Enzyme of the Nicotinate Catabolism
[作者:Kress, D; Alhapel, A; Pierik, AJ; Essen, LO,期刊:Journal of Molecular Biology, 页码:837-847 , 文章类型: Article,,卷期:2008年384-4]
- The hydrolysis of 1,4,5,6-tetrahydro-6-oxonicotinate to 2-formylglutarate is a central step in the catabolism of nicotinate in several Clostridia and Proteobacteria. Thus reaction is catalyzed by the novel enzyme enamida...
- Crystal Structures of Monomeric Actin Bound to Cytochalasin D
[作者:Nair, UB; Joel, PB; Wan, Q; Lowey, S; Rould, MA; Trybus, KM,期刊:Journal of Molecular Biology, 页码:848-864 , 文章类型: Article,,卷期:2008年384-4]
- The fungal toxin cytochalasin D (CD) interferes with the normal dynamics of the actin cytoskeleton by binding to the barbed end of actin filaments. Despite its widespread use as a tool for studying actin-mediated process...
- A D-Pathway Mutation Decouples the Paracoccus denitrificans Cytochrome c Oxidase by Altering the Side-Chain Orientation of a Distant Conserved Glutamate
[作者:Durr, KL; Koepkee, J; Hellwig, P; Muller, H; Angerere, H; Peng, G; Olkhova, E; Richter, OMH; Ludwig, B; Michele, H,期刊:Journal of Molecular Biology, 页码:865-877 , 文章类型: Article,,卷期:2008年384-4]
- Asparagine 131, located near the cytoplasmic entrance of the D-pathway in subunit I of the Paracoccus denitrificans aa(3) cytochrome c oxidase, is a residue crucial for proton pumping: When replaced by an aspartate, the ...
- Biochemical and Structural Studies of Yeast Vps4 Oligomerization
[作者:Gonciarz, MD; Whitby, FG; Eckert, DM; Kieffer, C; Heroux, A; Sundquist, WI; Hill, CP,期刊:Journal of Molecular Biology, 页码:878-895 , 文章类型: Article,,卷期:2008年384-4]
- The ESCRT (endosomal sorting complexes required for transport) pathway functions in vesicle formation at the multivesicular body, the budding of enveloped RNA viruses such as HIV-1, and the final abscission stage of cyto...
- Ubipuitin-Proteasome System Impairment Caused by a Missense Cardiac Myosin-binding Protein C Mutation and Associated with Cardiac Dysfunction in Hypertrophic Cardiomyopathy
[作者:Bahrudin, U; Morisaki, H; Morisaki, T; Ninomiya, H; Higaki, K; Nanba, E; Igawa, O; Takashima, S; Mizutas, E; Miake, J; Yamamoto, Y; Shirayoshi, Y; Kitakaze, M; Carrier, L; Hisatome, I,期刊:Journal of Molecular Biology, 页码:896-907 , 文章类型: Article,,卷期:2008年384-4]
- The ubiquitin-proteasome system is responsible for the disappearance of truncated cardiac myosin-binding protein C, and the suppression of its activity contributes to cardiac dysfunction. This study investigated whether ...
- RBBP6 Interacts with Multifunctional Protein YB-1 through Its RING Finger Domain, Leading to Ubiquitination and Proteosomal Degradation of YB-1
[作者:Chibi, M; Meyer, M; Skepu, A; Rees, DJG; Moolman-Smook, JC; Pugh, DJR,期刊:Journal of Molecular Biology, 页码:908-916 , 文章类型: Article,,卷期:2008年384-4]
- RBBP6 (retinoblastoma binding protein 6) is a 250-kDa multifunctional protein that interacts with both p53 and pRb and has been implicated in mRNA processing. It has also been identified as a putative E3 ubiquitin ligase...
- Anti-oligomeric A beta Single-chain Variable Domain Antibody Blocks A beta-induced Toxicity Against Human Neuroblastoma Cells
[作者:Zameer, A; Kasturirangan, S; Emadi, S; Nimmagadda, SV; Sierks, MR,期刊:Journal of Molecular Biology, 页码:917-928 , 文章类型: Article,,卷期:2008年384-4]
- The Amyloid-beta (A beta) peptide is a major component of the amyloid plaques associated with Alzheimer's disease (AD). Recent studies suggest that the most toxic forms of A beta are small, soluble oligomeric aggregates....
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