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  • Genetic Variation in IL28B Is Associated With Chronic Hepatitis C and Treatment Failure: A Genome-Wide Association Study
    [作者:Rauch, A; Kutalik, Z; Descombes, P; Cai, T; Di Iulio, J; Mueller, T; Bochud, M; Battegay, M; Bernasconi, E; Borovicka, J; Colombo, S; Cerny, A; Dufour, JF; Furrer, H; Gunthard, HF; Heim, M; Hirschel, B; Malinverni, R; Moradpour, D; Mullhaupt, B; Witteck, A; Beckmann, JS; Berg, T; Bergmann, S; Negro, F; Telenti, A; Bochud, PY,期刊:Gastroenterology, 页码:1338-U173 , 文章类型: Article,,卷期:2010年138-4]
  • BACKGROUND & AIMS: Hepatitis C virus (HCV) induces chronic infection in 50% to 80% of infected persons; approximately 50% of these do not respond to therapy. We performed a genome-wide association study to screen for hos...
  • Farglitazar Lacks Antifibrotic Activity in Patients With Chronic Hepatitis C Infection
    [作者:McHutchison, J; Goodman, Z; Patel, K; Makhlouf, H; Rodriguez-Torres, M; Shiffman, M; Rockey, D; Husa, P; Chuang, WL; Levine, R; Jonas, M; Theodore, D; Brigandi, R; Webster, A; Schultz, M; Watson, H; Stancil, B; Gardner, S,期刊:Gastroenterology, 页码:1365-U208 , 文章类型: Article,,卷期:2010年138-4]
  • BACKGROUND & AIMS: Farglitazar (GI262570), an insulin-sensitizing agent, selectively binds and activates peroxisome proliferator-activated receptor gamma (PPAR gamma) and inhibits stellate cell activation. We evaluated i...
  • Tumor Necrosis Factor and Interferon-gamma Down-regulate Klotho in Mice With Colitis
    [作者:Thurston, RD; Larmonier, CB; Majewski, PM; Ramalingam, R; Midura-Kiela, M; Laubitz, D; Vandewalle, A; Besselsen, DG; Muhlbauer, M; Jobin, C; Kiela, PR; Ghishan, FK,期刊:Gastroenterology, 页码:1384-U231 , 文章类型: Article,,卷期:2010年138-4]
  • BACKGROUND & AIMS: Klotho (KL) is an anti-inflammatory protein that protects the endothelium from nitric oxide (NO)-induced dysfunction, reduces the expression of endothelial adhesion molecules, and potentially regulates...
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